KR950003262A - 1-aryloxy-3-alkylamino-2-propanol nitrate esters, uses thereof and corresponding pharmaceutical compositions - Google Patents

1-aryloxy-3-alkylamino-2-propanol nitrate esters, uses thereof and corresponding pharmaceutical compositions Download PDF

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Publication number
KR950003262A
KR950003262A KR1019940018560A KR19940018560A KR950003262A KR 950003262 A KR950003262 A KR 950003262A KR 1019940018560 A KR1019940018560 A KR 1019940018560A KR 19940018560 A KR19940018560 A KR 19940018560A KR 950003262 A KR950003262 A KR 950003262A
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South Korea
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formula
enantiomers
diastereomers
isopropylamino
compounds
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KR1019940018560A
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Korean (ko)
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프라트 퀴뇨네스 마리아
피 살렌트 호안
베드릴라 베이트 다그마르
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세바스챤 줄리아 아레카가
프로데스파르마, 에스.에이
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Publication of KR950003262A publication Critical patent/KR950003262A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The above nitrate esters, having formula I: <CHEM> the enantiomers and diastereoisomers and the therapeutically acceptable salts thereof, wherein R1 is a chain of general formula II - (-CH2)m - Z - R2, where: m is 1 or 2; Z is an -O- ether, -CONH amide or -COO- ester function; and R2 is a C2-3 straight or branched chain alkyl having at least one nitroxy group as substituent; and Ar is a benzene ring when Z is the ether or ester function, and a naphthalene ring when Z is the amide function, are of use for the treatment of cardiovascular affections.

Description

1-아릴옥시-3-알킬아미노-2-프로판올 니트레이트 에스테르, 이의 용도 및 상응하는 약제학적 조성물1-aryloxy-3-alkylamino-2-propanol nitrate esters, uses thereof and corresponding pharmaceutical compositions

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (8)

일반식(Ⅰ)의 1-아릴옥시-3-알킬아미노-2-프로판올 니트레이트 에스테르, 에탄티오머 및 부분입체이성체 및 지료적으로 허용되는 이의 유기 및 무기산염.1-aryloxy-3-alkylamino-2-propanol nitrate esters, ethanethiomers and diastereomers of general formula (I) and organically acceptable inorganic and salts thereof. 상기식에서, R1은 일반식(Ⅱ)의 쇄Wherein R 1 is a chain of formula (II) (CH2)m-Z-R2(Ⅱ)(CH 2 ) m -ZR 2 (II) (여기에서, m은 1 또는 2이고, Z는 -O-에테르, -CONH 아미드 또는 -COO-에스테르 관능기이며, R2는 치환체로써 하나 이상의 니트록시 그룹을 갖는 C2-3직쇄 또는 측쇄 알킬이다)이고, Ar은 Z가 에테르 또는 에스테르 관능기일 때 벤젠환이고, Z가 아미드 관능기일 때 나프탈렌 환이다.Wherein m is 1 or 2, Z is an -O-ether, -CONH amide or -COO-ester functional group and R 2 is C 2-3 straight or branched chain alkyl having at least one nitrooxy group as a substituent ), Ar is a benzene ring when Z is an ether or ester functional group, and Ar is a naphthalene ring when Z is an amide functional group. 제1항에 있어서, 다음 그룹, 즉 1-이소프로필아미노-3-[4-(2-니트록시)에톡시메틸] 페녹시-2-프로판올, 1-이소프로필아미노-3-[4-(3-니트록시)프로폭시메틸]페녹시-2-프로판올, 1-이소프로필아미노-3-[4-(2,3-디니트록시)프로폭시메틸]페녹시-2-프로판올, 1-(2-하이드록시-3-이소프로필아미노)프로폭시-N-(2-니트록시에틸)-2-나프탈렌 아세트아미드, 2-(2-하이드록시-3-이소프로필아미노)프로폭시-N-(2-니트록시에틸)-1-나프탈렌 아세트아미드 및 2-니트록시에틸 4-[(2-하이드록시-3-이소프로필아미노)프로폭시]페닐 아세테이트로 이루어진 그룹중에서 선택되는 일반식(Ⅰ)의 니트레이트에스테르.The compound according to claim 1, wherein the following group is used: 1-isopropylamino-3- [4- (2-nitrooxy) ethoxymethyl] phenoxy-2-propanol, 1-isopropylamino-3- [4- ( 3-nitoxy) propoxymethyl] phenoxy-2-propanol, 1-isopropylamino-3- [4- (2,3-dinithoxy) propoxymethyl] phenoxy-2-propanol, 1- ( 2-hydroxy-3-isopropylamino) propoxy-N- (2-nitroethylethyl) -2-naphthalene acetamide, 2- (2-hydroxy-3-isopropylamino) propoxy-N- ( 2-nitoxyethyl) -1-naphthalene acetamide and 2-nitoxyethyl 4-[(2-hydroxy-3-isopropylamino) propoxy] phenyl acetate of formula (I) Nitrate esters. 사람에 있어서, 심장혈관 질환의 치료 또는 예방용 관상동맥 혈관확장제 작용 약물의 제조를 위한, 제1항에 따르는 일반식(Ⅰ)의 화합물, 에난티오머 및 부분입체이성체 및 치료적으로 허용되는 이의 염의 용도.In humans, the compounds of formula (I), enantiomers and diastereomers according to claim 1 for the preparation of a coronary dilator drug for the treatment or prevention of cardiovascular diseases and therapeutically acceptable thereof Use of salts. 사람에 있어서, 심장혈관 질환의 치료 또는 예방용 β1-아드레날린 작용성 차단 활성 약물의 제조를 위한, 제1항에 따르는 일반식(Ⅰ)의 화합물, 에난티오머 및 부분입체이성체 및 치료적으로 허용되는 이의 염의 용도.In humans, the compounds, enantiomers and diastereomers of formula (I) according to claim 1 for the preparation of β1-adrenergic blocking active drugs for the treatment or prevention of cardiovascular diseases, and therapeutically acceptable The use of salts thereof. 정제 형태로 제조된, 제1항에 따르는 일반식(Ⅰ)의 화합물, 에난티오머 및 부분입체이성체 및 치료적으로 허용되는 이의 염을 하나 이상 포함하는 약제학적 조성물.A pharmaceutical composition comprising one or more compounds of formula (I), enantiomers and diastereomers and therapeutically acceptable salts thereof according to claim 1, prepared in tablet form. 서방성 정제 형태로 제조된, 제1항에 따르는 일반식(Ⅰ)의 화합물, 에난티오머 및 부분입체이성체 및 치료적으로 허용되는 이의 염을 하나 이상 포함하는 약제학적 조성물.A pharmaceutical composition comprising one or more compounds of formula (I), enantiomers and diastereomers according to claim 1 and therapeutically acceptable salts thereof, prepared in the form of sustained-release tablets. 캅셀제 정제 형태로 제조된, 제1항에 따르는 일반식(Ⅰ)의 화합물, 에난티오머 및 부분입체이성체 및 치료적으로 허용되는 이의 염을 하나 이상 포함하는 약제학적 조성물.A pharmaceutical composition comprising one or more compounds of formula (I), enantiomers and diastereomers according to claim 1 and therapeutically acceptable salts thereof, prepared in the form of a capsule tablet. 주사제 형태로 제조된, 제1항에 따르는 일반식(Ⅰ)의 화합물, 에난티오머 및 부분입체이성체 및 치료적으로 허용되는 이의 염을 하나 이상 포함하는 약제학적 조성물.A pharmaceutical composition comprising one or more compounds of formula (I), enantiomers and diastereomers according to claim 1 and therapeutically acceptable salts thereof, prepared in the form of an injection. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940018560A 1993-07-30 1994-07-29 1-aryloxy-3-alkylamino-2-propanol nitrate esters, uses thereof and corresponding pharmaceutical compositions KR950003262A (en)

Applications Claiming Priority (2)

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ES9301721 1993-07-30
ES09301721A ES2065291B1 (en) 1993-07-30 1993-07-30 "1-ARYLOXI-3-ALKYLAMINO-2-PROPANOLS NITRATE ESTERS, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION"

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US (2) US5502237A (en)
EP (1) EP0637583B1 (en)
JP (1) JP2777572B2 (en)
KR (1) KR950003262A (en)
AT (1) ATE146453T1 (en)
AU (1) AU666626B2 (en)
CA (1) CA2128671A1 (en)
CO (1) CO4290296A1 (en)
DE (1) DE69401177T2 (en)
DK (1) DK0637583T3 (en)
ES (1) ES2065291B1 (en)
GR (1) GR3022704T3 (en)
HU (1) HU214827B (en)
MX (1) MX9405660A (en)
NO (1) NO179746C (en)
NZ (1) NZ264118A (en)
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190013325A (en) 2017-08-01 2019-02-11 강흥섭 Dual pressing device for manufacturing double-layered glass
KR20190013324A (en) 2017-08-01 2019-02-11 강흥섭 Dual dual layer glass manufacturing equipment
KR20190028070A (en) 2017-09-08 2019-03-18 강흥섭 Dual dual layer glass manufacturing equipment
KR20190000686U (en) 2017-09-08 2019-03-18 강흥섭 Glass Plate Inspection Apparatus for Double-layered Glass
KR102163495B1 (en) 2019-08-22 2020-10-07 주식회사 아이지스 double press device having gas injection of multi-layer glass
KR20210020341A (en) 2019-08-14 2021-02-24 주식회사 아이지스 conveyor auto division suppler for manufacturing multi layer glass

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1295694B1 (en) * 1996-11-14 1999-05-27 Nicox Sa NITROXIS DERIVATIVES FOR THE PREPARATION OF MEDICATIONS WITH ANTI-THROMBINIC ACTIVITY
CN1083824C (en) * 1999-09-24 2002-05-01 许景峰 Synthetic compound having cardiovascular pharmacological activity and its preparing process
WO2005018561A2 (en) * 2003-08-20 2005-03-03 Nitromed, Inc. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
EP1691804B1 (en) 2003-12-02 2007-04-04 NicOx S.A. Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive drugs
JP2007513113A (en) * 2003-12-02 2007-05-24 ニコックス エス エイ Nitrooxy derivatives of antihypertensive drugs
WO2006052899A2 (en) * 2004-11-08 2006-05-18 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods for the treatment of ophthalmic disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE354851B (en) * 1970-02-18 1973-03-26 Haessle Ab
DE2839475A1 (en) * 1978-09-11 1980-03-20 Dolorgiet Arzneimittelfabrik ISOPROPYLAMINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME
JPS56113748A (en) * 1980-02-13 1981-09-07 Kowa Co Aminoethanol derivative and its preparation
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
JPS58109461A (en) * 1981-12-24 1983-06-29 Kowa Co Novel benzamide derivative
DE3443998A1 (en) * 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim AMINO-PROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND INTERMEDIATE PRODUCTS
NL8802276A (en) * 1988-09-15 1990-04-02 Cedona Pharm Bv MEDICINAL PRODUCT WITH RELAXING EFFECT, CONTAINING A NITRATE ESTER AS ACTIVE SUBSTANCE.
IT1243367B (en) * 1990-07-26 1994-06-10 Italfarmaco Spa BENZOIC ACID DERIVATIVES SUBSTITUTED FOR CARDIOVASCULAR ACTIVITY
ES2026756A6 (en) * 1990-09-24 1992-05-01 Prodesfarma Sa Procedure for obtaining nitrates of 1-aryloxy-3-amino-2- propyl

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190013325A (en) 2017-08-01 2019-02-11 강흥섭 Dual pressing device for manufacturing double-layered glass
KR20190013324A (en) 2017-08-01 2019-02-11 강흥섭 Dual dual layer glass manufacturing equipment
KR20190028070A (en) 2017-09-08 2019-03-18 강흥섭 Dual dual layer glass manufacturing equipment
KR20190000686U (en) 2017-09-08 2019-03-18 강흥섭 Glass Plate Inspection Apparatus for Double-layered Glass
KR20210020341A (en) 2019-08-14 2021-02-24 주식회사 아이지스 conveyor auto division suppler for manufacturing multi layer glass
KR102163495B1 (en) 2019-08-22 2020-10-07 주식회사 아이지스 double press device having gas injection of multi-layer glass

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Publication number Publication date
US5502237A (en) 1996-03-26
EP0637583B1 (en) 1996-12-18
ES2065291B1 (en) 1995-10-01
NO179746C (en) 1996-12-11
NO942568D0 (en) 1994-07-07
DE69401177T2 (en) 1997-04-24
JP2777572B2 (en) 1998-07-16
ES2065291A1 (en) 1995-02-01
EP0637583A1 (en) 1995-02-08
HU9402229D0 (en) 1994-09-28
NO179746B (en) 1996-09-02
DE69401177D1 (en) 1997-01-30
CO4290296A1 (en) 1996-04-17
CA2128671A1 (en) 1995-01-31
NZ264118A (en) 1995-04-27
DK0637583T3 (en) 1997-05-12
PL304406A1 (en) 1995-02-06
NO942568L (en) 1995-01-31
ZA945435B (en) 1995-05-11
JPH0789910A (en) 1995-04-04
MX9405660A (en) 1995-01-31
HU214827B (en) 1998-06-29
US5639904A (en) 1997-06-17
GR3022704T3 (en) 1997-05-31
AU6743794A (en) 1995-02-09
ATE146453T1 (en) 1997-01-15
PL175707B1 (en) 1999-01-29
HUT71813A (en) 1996-02-28
AU666626B2 (en) 1996-02-15

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