KR950000879A - Novel Human Immunodeficiency Virus-2 (HIV-2) - Google Patents

Novel Human Immunodeficiency Virus-2 (HIV-2) Download PDF

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Publication number
KR950000879A
KR950000879A KR1019940012648A KR19940012648A KR950000879A KR 950000879 A KR950000879 A KR 950000879A KR 1019940012648 A KR1019940012648 A KR 1019940012648A KR 19940012648 A KR19940012648 A KR 19940012648A KR 950000879 A KR950000879 A KR 950000879A
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KR
South Korea
Prior art keywords
hiv
immunodeficiency virus
human immunodeficiency
species
present
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KR1019940012648A
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Korean (ko)
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KR0155598B1 (en
Inventor
김선영
김선희
이혜영
Original Assignee
김영길
주식회사 녹십자
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Publication of KR950000879A publication Critical patent/KR950000879A/en
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Publication of KR0155598B1 publication Critical patent/KR0155598B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material

Abstract

본 발명은 HIV-2 보균자로부터 새로이 분리된 HIV-2 바이러스, 그의 신규한 유전자와 그로부터 번역되는 단백질에 관한 것이다.The present invention relates to HIV-2 viruses newly isolated from HIV-2 carriers, their novel genes and proteins translated therefrom.

본 발명에서는 4명의 HIV-2 보균자(OG,MB,FT,TF)의 혈액으로부터 총 세포 DNA를 추출하고 프라이머를 이용하여 nef 유전자를 증폭한 다음, 공지의 HIV-2 ROD, ST 및 GH종과 nef 유전자의 염기서열 및 아미노산 서열의 상동성을 비교한 결과, 본 발명의 발명자들이 분리한 HIV-2 TG종이 신규한 것을 발견하였다.In the present invention, the total cell DNA is extracted from the blood of four HIV-2 carriers (OG, MB, FT, TF) and the nef gene is amplified using a primer, and then known HIV-2 ROD, ST and GH species are known. As a result of comparing the homology between the nucleotide sequence and the amino acid sequence of the nef gene, the inventors of the present invention found that the HIV-2 TG species isolated by the present inventors were novel.

본 발명의 신규한 HIV-2 TG종 유전자 및 단백질을 이용하여, HIV-2에 특이적인 단일클론항체, 백신 및 진단시약을 제조할 수 있을 것이다.The novel HIV-2 TG species genes and proteins of the present invention may be used to prepare monoclonal antibodies, vaccines and diagnostic reagents specific for HIV-2.

Description

신규한 인간 면역결핍 바이러스-2(HIV-2)Novel Human Immunodeficiency Virus-2 (HIV-2)

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제3도는 본 발명의 신규한 HIV-2 TG종의 nef 유전자의 염기서열 및 그로부터 번역되는 아미노산 서열을 나타낸 것이다.Figure 3 shows the nucleotide sequence of the nef gene of the novel HIV-2 TG species of the present invention and the amino acid sequence translated therefrom.

Claims (6)

TG종의 후천성 면역결핍증(AIDS) 환자로부터 분리된 신규한 인간 면역결핍 바이러스-2(HIV-2).Novel human immunodeficiency virus-2 (HIV-2) isolated from a patient with acquired immunodeficiency syndrome (AIDS) of TG species. 제1항의 인간 면역결핍 바이러스-2(HIV-2)로부터 분리한 다음과 같은 뉴클레오티드 서열을 가지는 nef 유전자.A nef gene having the following nucleotide sequence isolated from the human immunodeficiency virus-2 (HIV-2) of claim 1. 제1항의 인간 면역결핍 바이러스-2(HIV-2)로부터 분리한 다음과 같은 아미노산 서열을 가지는 nef 단백질.A nef protein having the following amino acid sequence isolated from human immunodeficiency virus-2 (HIV-2) of claim 1. 제1항의 인간 면역결핍 바이러스-2(HIV-2) 종이나 그의 일부 유전자 및 단백질들을 사용하여 제조한 단일클론항체.A monoclonal antibody prepared using the human immunodeficiency virus-2 (HIV-2) species of claim 1 or some genes and proteins thereof. 제1항의 인간 면역결핍 바이러스-2(HIV-2) 종이나 그의 일부 유전자 및 단백질들을 사용하여 제조한 HIV-2 백신.An HIV-2 vaccine prepared using the human immunodeficiency virus-2 (HIV-2) species of claim 1 or some genes and proteins thereof. 제1항의 인간 면역결핍 바이러스-2(HIV-2) 종이나 그의 일부 유전자 및 단백질들을 사용하여 제조한 HIV-2 진단시약.An HIV-2 diagnostic reagent prepared using the human immunodeficiency virus-2 (HIV-2) species of claim 1 or some genes and proteins thereof. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940012648A 1993-06-07 1994-06-04 Nef gene separated novel hiv-2 and protein KR0155598B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR930010192 1993-06-07
KR93-10192 1993-06-07

Publications (2)

Publication Number Publication Date
KR950000879A true KR950000879A (en) 1995-01-03
KR0155598B1 KR0155598B1 (en) 1998-10-15

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KR1019940012648A KR0155598B1 (en) 1993-06-07 1994-06-04 Nef gene separated novel hiv-2 and protein

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KR0155598B1 (en) 1998-10-15

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