KR940019738A - Method for preparing a coating liquid release polymer and release polymer prepared therefrom - Google Patents

Method for preparing a coating liquid release polymer and release polymer prepared therefrom Download PDF

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Publication number
KR940019738A
KR940019738A KR1019940003528A KR19940003528A KR940019738A KR 940019738 A KR940019738 A KR 940019738A KR 1019940003528 A KR1019940003528 A KR 1019940003528A KR 19940003528 A KR19940003528 A KR 19940003528A KR 940019738 A KR940019738 A KR 940019738A
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South Korea
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polymer
coating liquid
polymerization
liquid release
release polymer
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KR1019940003528A
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Korean (ko)
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KR960000566B1 (en
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최재영
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최재영
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F18/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid
    • C08F18/02—Esters of monocarboxylic acids
    • C08F18/04—Vinyl esters
    • C08F18/08—Vinyl acetate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/02—Polymerisation in bulk
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/44—Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F218/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid
    • C08F218/02—Esters of monocarboxylic acids
    • C08F218/04—Vinyl esters
    • C08F218/08—Vinyl acetate

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Paints Or Removers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

본 발명은 산업용으로 사용되고 있는 도료형 액상 이형필름을 의료용형태로 개발하여 외상치료에 사용되는 새로운 약물전달 시스템으로 개발하고자 한 것으로, 의료용 도료형 액상 이형중합체의 제조방법 및 이 방법에 의해 제조된 이형중합체 그리고 이를 함유하는 제품에 관한 것이다.The present invention is to develop a coating liquid release film that is used for industrial purposes in a medical form to develop a new drug delivery system used in the treatment of trauma, a method for producing a medical coating liquid release polymer and release prepared by this method It relates to a polymer and a product containing the same.

좀더 구체적으로는 비닐아세테이트를 기본물질로 사용하여 현탁중합하고 이것을 괴상중합시에 다시 혼합하여 중합하는 2단계 중합공정으로 구성되고, 이로서 얻어지는 중합체는 물-알콜혼합 용액에 용해되는 반수성-반유성의 성격을 갖게되어 의약품을 쉽게 용해하여 새로운 약물 전달 고분자로서 이용될 수 있다.More specifically, it consists of a two-stage polymerization process in which the suspension is polymerized using vinyl acetate as a base material and mixed and polymerized again during bulk polymerization, and the polymer thus obtained is semi-aqueous-anti-oil-soluble in a water-alcohol mixture solution. It has the character and can be easily dissolved as a new drug delivery polymer.

Description

도료형 액상 이형중합체의 제조방법 및 이로부터 제조된 이형중합체Method for preparing a coating liquid release polymer and release polymer prepared therefrom

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 본 발명에 따라 제조된 도료형 액상 이형필름의 피부에서의 메카니즘을 개략적으로 도시한 도면이다.1 is a view schematically showing the mechanism in the skin of the coating liquid release film prepared according to the present invention.

Claims (14)

가) 비닐아세테이트를 분산제로 분산시키고, 여기에 레독스개시제를 첨가하여 현탁중합하는 단계 및 나) 비닐아세테이트를 적어도 1종이상의 이 비닐아세테이트와 다른 비닐모노머들과 괴상중합시키면서 상기 가)의 현탁중합체를 첨가하여 현탁/괴상중합하는 단계로 구성되는 것을 특징으로 하는 도료형 액상 이형 중합체의 제조방법.A) dispersing the vinyl acetate with a dispersant and suspending polymerization by adding a redox initiator to it; and b) suspending polymer of a) while bulk polymerization of the vinyl acetate with at least one or more of these vinyl acetates and other vinyl monomers. Method for producing a coating liquid release polymer comprising a step of suspending / bulk polymerization by adding. 제1항에 있어서, 다) 수세, 건조하는 단계가 더 포함되는 것을 특징으로 하는 도료형 액상 이형 중합체의 제조방법.[Claim 2] The method of claim 1, further comprising: washing with water and drying. 제1항에 있어서, 상기 나)단계의 비닐모노머가 스틸렌, 올레익산 테트라클로로에틸렌 또는 아크릴계모노머인 것을 특징으로 하는 도료형 액상 이형 중합체의 제조방법.The method according to claim 1, wherein the vinyl monomer of step b) is styrene, oleic acid tetrachloroethylene or acrylic monomer. 제1항, 제2항 또는 제3항에 있어서, 이형제가 첨가되는 단계가 더 포함되는 것을 특징으로 하는 도료형 액상 이형 중합체의 제조방법.The method for producing a coating liquid release polymer according to claim 1, 2 or 3, further comprising adding a release agent. 제1항에 있어서, 상기 현탁/괴상중합단계에서 현탁중합체가 괴상중합체에 대하여 1 내지 99중량%로 첨가됨을 특징으로 하는 도료형 액상 이형 중합체의 제조방법.The method of claim 1, wherein in the suspension / block polymerization step, the suspension polymer is added in an amount of 1 to 99% by weight relative to the block polymer. 제4항에 있어서, 상기 이형제가 솔비탄류, 폴리옥시에틸렌솔비탄에스테르류, 폴리옥시에틸렌라우릴에테르, 알킬아릴폴리에테르 또는 4가 암모늄염으로 구성된 군으로부터 하나 또는 그 이상 선택되고, 상기 중합반응이 끝난 중합체 고형분에 대하여 0.1 내지 5중량%로 첨가됨을 특징으로 하는 도료형 액상 이형 중합체의 제조방법.The method according to claim 4, wherein the release agent is selected from the group consisting of sorbitan, polyoxyethylene sorbitan esters, polyoxyethylene lauryl ether, alkylaryl polyether or tetravalent ammonium salt, and the polymerization reaction is A method for producing a coating liquid release polymer, characterized in that added to 0.1 to 5% by weight based on the finished polymer solids. 가) 비닐아세테이트를 분산제로 분산시키고, 여기에 레독스개시제를 첨가하여 현탁중합하는 단계, 및 나) 비닐아세테이트를 적어도 1종이상의 이 비닐아세테이트와 다른 비닐계 모노머를 가하고, 블렌딩(blending) 또는 체인 트랜스퍼(chain transfer reaction) 반응이 가능한 적어도 1종 이상의 다른 화합물을 첨가하여 괴상중합하면서 상기 가)의 현탁중합체를 첨가하여 현탁/괴상중합하는 단계로 구성되는 것을 특징으로 하는 도료형 액상 이형 중합체의 제조방법.A) dispersing the vinyl acetate with a dispersant, suspending polymerization by adding a redox initiator to it, and b) blending the vinyl acetate with at least one vinyl acetate and another vinyl monomer, and blending or chaining Preparation of a coating liquid release polymer comprising a step of suspending / blocking polymerization by adding a suspension polymer of a) while adding a block polymerization and adding at least one other compound capable of a chain transfer reaction. Way. 제7항에 있어서, 다) 수세, 건조하는 단계가 더 포함되는 것을 특징으로 하는 도료형 액상 이형 중합체의 제조방법.8. The method for preparing a coating liquid release polymer according to claim 7, further comprising: washing with water and drying. 제7항에 있어서, 상기 나) 단계의 비닐모노머가 스틸렌, 올레익산 테트라클로로에틸렌 또는 아클릴계 모노머인 것을 특징으로 하는 도료형 액상 이형 중합체의 제조방법.The method according to claim 7, wherein the vinyl monomer of step b) is a styrene, oleic acid tetrachloroethylene or acryl-based monomer. 제7항, 제8항 또는 9항에 있어서, 이형제가 첨가되는 단계가 더 포함되는 것을 특징으로 하는 도료형 액상 이형 중합체의 제조방법.10. The method according to claim 7, 8 or 9, further comprising the step of adding a release agent. 제7항에 있어서, 상기 현탁/괴상중합단계에서 현탁중합체가 괴상중합체에 대하여 1 내지 99중량%로 첨가됨을 특징으로 하는 도료형 액상 이형 중합체의 제조방법.The method according to claim 7, wherein in the suspension / block polymerization step, the suspension polymer is added in an amount of 1 to 99% by weight based on the block polymer. 제10항에 있어서, 상기 이형제가 솔비탄류, 폴리옥시에틸렌솔비탄에스테르류, 폴리옥시에틸렌라우릴에테르, 알킬아릴폴리에테르 또는 4가 암모늄염으로 구성된 군으로부터 하나 또는 그 이상 선택되고, 상기 중합반응이 끝난 중합체 고형분에 대하여 0.1 내지 5중량%로 첨가됨을 특징으로 하는 도료형 액상 이형 중합체의 제조방법.11. The method according to claim 10, wherein the release agent is selected from the group consisting of sorbitan, polyoxyethylene sorbitan esters, polyoxyethylene lauryl ether, alkylaryl polyether or tetravalent ammonium salt, and the polymerization reaction is A method for producing a coating liquid release polymer, characterized in that added to 0.1 to 5% by weight based on the finished polymer solids. 제1항 내지 제12항의 어느 한 항의 방법에 의해 제조되는 것을 특징으로 하는 도료형 액상 이형 중합체.A coating liquid release polymer, which is prepared by the method according to any one of claims 1 to 12. 제13항의 중합체에 수용성 또는 지용성 의약품 또는 한약제가 더 포함되는 것을 특징으로 하는 의료용 이형필름 조성물.A medical release film composition, characterized in that the polymer of claim 13 further comprises a water-soluble or fat-soluble medicine or herbal medicine. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940003528A 1993-02-25 1994-02-25 Process for producing a liquid polymer for paints and polymer thereof KR960000566B1 (en)

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KR1019940003528A KR960000566B1 (en) 1993-02-25 1994-02-25 Process for producing a liquid polymer for paints and polymer thereof

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KR2706 1993-02-25
KR930002706 1993-02-25
KR1019940003528A KR960000566B1 (en) 1993-02-25 1994-02-25 Process for producing a liquid polymer for paints and polymer thereof

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KR940019738A true KR940019738A (en) 1994-09-14
KR960000566B1 KR960000566B1 (en) 1996-01-09

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