KR940019713A - Method for preparing a novel cephalosporin derivative - Google Patents

Method for preparing a novel cephalosporin derivative Download PDF

Info

Publication number
KR940019713A
KR940019713A KR1019930002902A KR930002902A KR940019713A KR 940019713 A KR940019713 A KR 940019713A KR 1019930002902 A KR1019930002902 A KR 1019930002902A KR 930002902 A KR930002902 A KR 930002902A KR 940019713 A KR940019713 A KR 940019713A
Authority
KR
South Korea
Prior art keywords
cephalosporin
group
hydrogen
formula
azole
Prior art date
Application number
KR1019930002902A
Other languages
Korean (ko)
Inventor
문웅식
Original Assignee
문웅식
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 문웅식 filed Critical 문웅식
Priority to KR1019930002902A priority Critical patent/KR940019713A/en
Publication of KR940019713A publication Critical patent/KR940019713A/en

Links

Landscapes

  • Cephalosporin Compounds (AREA)

Abstract

본 발명은 제약산업에서 사용되고 신규세팔로스포린계 항생제로서 공지된 사실이 없는 유도체를 제조하고자 했다.The present invention seeks to produce derivatives which are used in the pharmaceutical industry and which are known as novel cephalosporin-based antibiotics.

이 신규 화합물을 제조하기 위하여 기존의 세팔로스포린 모핵인 7-세팔로스포라닉산과 아졸치환체들을 치환 반응시켜 신규물질을 제조하였으며, 또한 기존의 화합물인 7-아미노3-크로로메칠-3-세펨-4-카복실산-파라-메톡시 벤질에스테르염(ACLE)을 사용하여 또 다른 아졸치환체들을 치환 반응시켜 또 다른 신규 물질을 제조하였다.In order to prepare this new compound, a new substance was prepared by substitution reaction of the existing cephalosporin nucleus, 7-cephalosporonic acid, and azole substituents, and also a new compound 7-amino3-chloromethyl-3-sefem. Another novel material was prepared by substitution reaction of other azole substituents using the 4-carboxylic acid-para-methoxy benzyl ester salt (ACLE).

이렇게 해서 얻어진 화합물들을 기존의 다른 세팔로스포린 유도체들에서와 마찬가지로 약제화적으로 사용하려 한다.The compounds thus obtained are intended to be used pharmacologically as in other cephalosporin derivatives.

Description

신규 세팔로스포린 유도체의 제조방법Method for preparing a novel cephalosporin derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도, 제2도, 제3도는 본 발명에 따르는 신규 세팔로스포린 유도체의 구조를 나타낸 것.1, 2 and 3 show the structure of the novel cephalosporin derivatives according to the invention.

Claims (3)

하기 일반식(Ⅰ)의 세팔로스포린 화합물에서In the cephalosporin compound of formula (I) Z는 수소, 세팔로스포린 제조에서 통상적으로 사용 되는 보호그룹 또는 공지 된 7-아실 아미노 세팔로스포린 항생제의 아실그룹이고 X는 황(S), 질소(N), 산소(O)이며, L은 수소 또는 알콕시기이고 R1과 R2는 H 또는 알킬이며 R7은 수소, 염, 알킬그룹이다.Z is hydrogen, a protecting group commonly used in cephalosporin preparation or an acyl group of known 7-acyl amino cephalosporin antibiotics, X is sulfur (S), nitrogen (N), oxygen (O), and L is Hydrogen or an alkoxy group, R 1 and R 2 are H or alkyl and R 7 is hydrogen, a salt, an alkyl group. 하기 일반식(Ⅱ)의 세팔로스포린 화합물에서In the cephalosporin compound of formula (II) 상기식의 Z,X,L,R1,R2,R7은 제1항에서 정의한바와 같다.Z, X, L, R 1 , R 2 , R 7 in the formula are as defined in claim 1. 하기 일반식(Ⅲ)의 세팔로스포린 화합물에서In the cephalosporin compound of formula (III) Z,R7,L은 제1항에서 정의한바와 같고, R3,R5는 수소 또는 알킬기나 수산기이며, R4와 R6는 알킬기 또는 알콕시기, 수소, 수산기이다.Z, R 7 and L are as defined in claim 1, R 3 and R 5 are hydrogen or an alkyl group or a hydroxyl group, and R 4 and R 6 are an alkyl group or an alkoxy group, hydrogen or a hydroxyl group. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019930002902A 1993-02-27 1993-02-27 Method for preparing a novel cephalosporin derivative KR940019713A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019930002902A KR940019713A (en) 1993-02-27 1993-02-27 Method for preparing a novel cephalosporin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019930002902A KR940019713A (en) 1993-02-27 1993-02-27 Method for preparing a novel cephalosporin derivative

Publications (1)

Publication Number Publication Date
KR940019713A true KR940019713A (en) 1994-09-14

Family

ID=66866038

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930002902A KR940019713A (en) 1993-02-27 1993-02-27 Method for preparing a novel cephalosporin derivative

Country Status (1)

Country Link
KR (1) KR940019713A (en)

Similar Documents

Publication Publication Date Title
KR940007022A (en) Piperidine derivatives, their use in the preparation and treatment thereof
AU6128590A (en) Novel compounds
AU515774B2 (en) Benzopyran derivatives
KR870006039A (en) Novel thiazole compound, preparation method thereof and pharmaceutical composition containing the compound
AT384424B (en) METHOD FOR PRODUCING NEW 3-HYDROXY-2-OXO-PYRROLIDINE DERIVATIVES AND THEIR SALTS
KR920008018A (en) Method for preparing piperazine derivatives
PT98362A (en) PROCESS FOR THE PREPARATION OF TIOALQUILTIO-CEFALOSPORIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
KR960007592A (en) New pyrrolocarbazole
KR900003156A (en) Analgesic compound, preparation method thereof and pharmaceutical composition containing same
KR960029337A (en) A camptothecin derivative, a pharmaceutically acceptable salt thereof, a preparation method thereof and an anticancer drug containing the same
EA200000484A1 (en) METHOD OF OBTAINING TIAZOLIDINDION DERIVATIVES
KR860008111A (en) Process for preparing indine and naphthalene derivatives
HUP9901212A2 (en) N-[2-(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives, pharmaceutical compositions containing the same and their use as local anaesthetics
KR890001965A (en) Spurgualine Related Derivatives
KR900003177A (en) Tetracyclic Antidepressants
KR890011893A (en) Process for preparing 7- [2- (2-aminothiazol-4-yl) -2-hydroxyimino acetaido] -3-cefem compound
KR870002150A (en) Method for preparing alkyl carbamoyloxymethyl sefem compound
KR940019713A (en) Method for preparing a novel cephalosporin derivative
KR870003107A (en) Method for preparing chianthine derivative
KR890002174A (en) Tricyclic Separm Compounds, Methods for Making and Uses thereof
KR930007880A (en) Bis (phenyl) ethane derivatives
KR920002564A (en) N-alkyl thiazolidine derivatives
DE3685942D1 (en) 2-PYRIDYL ACETIC DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
KR960010653A (en) New cephalosporin antibiotics and preparation method thereof
HU895651D0 (en) Process for the preparation of substituted 3-amino-nonimine derivatives and pharmaceutical compositions containing said compounds

Legal Events

Date Code Title Description
WITN Withdrawal due to no request for examination