KR940014388A - Method for preparing sulfonylurea derivative - Google Patents
Method for preparing sulfonylurea derivative Download PDFInfo
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- KR940014388A KR940014388A KR1019920023999A KR920023999A KR940014388A KR 940014388 A KR940014388 A KR 940014388A KR 1019920023999 A KR1019920023999 A KR 1019920023999A KR 920023999 A KR920023999 A KR 920023999A KR 940014388 A KR940014388 A KR 940014388A
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- hydrogen atom
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- phenyl
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Abstract
본 발명은 하기 일반식(Ⅶ)의 카바메이트 화합물을 용매 존재 또는 부재하에서 오염화인과 반응시킨 다음 하기 일반식(Ⅴ)의 피리미딘 유도체와 반응시킴을 특징으로 하여 하기 일반식(Ⅰ)로 표시되는 설포닐우레아 유도체를 제조하는 방법.The present invention is characterized by reacting a carbamate compound of formula (VII) with phosphorus pentachloride in the presence or absence of a solvent and then reacting with a pyrimidine derivative of formula (V) Method for preparing a sulfonylurea derivative.
상기식에서, A는 수소원자, C1-C8알킬기 또는 페닐기이고, B 및 C는 각각 독립적으로 수소원자, 할로겐원자, 니트로기, 또는 니트로기로 치환되어도 좋은 페닐기, C1-C8알킬기, C1-C8알콕시기, 할로겐화 알킬기, CO2R(여기서, R은 C1-C8알킬기, 아릴기 또는 프로파길기를 나타낸다), -CONR1R2(여기서, R1은 C1-C8알킬기 또는 페닐기를 나타내고, R2는 C1-C8알킬기를 나타내거나 R1및 R2가 함께 -(CH2)n-, -CH2CH2,-O-CH2CH2-, 또는 -CH2CH2N(CH3)CH2CH2-를 나타내며, 이때 n은 4, 5 또는 6을 나타낸다), -S(O)mR3(여기서, R3은 C1-C8알킬기, 페닐기 또는 아릴알킬기를 나타내고, m은 0, 1 또는 2를 나타낸다), -SO2R4R5(R4는 C1-C8알킬기를 나타내고, R5는 C1-C8알킬기를 나타내거나, 또는 R4, R5가 함께 -(CH2)p-, -CH2CH2-O-CH2CH2-또는 -CH2N(CH3)CH2CH2-를 나타내며, 단 P는 4, 5 또는 6을 나타낸다)을 나타내며, D는 수소원자 또는 C1-C8알킬기를 나타내며, X 및 Y는 독립적으로 수소원자, 할로겐원자, C1-C8알킬기, C1-C8알콕시시, C1-C8알콕시알킬기, -CF3기, C1-C8할로알킬기, 알킬아미노기, 디알킬아미노기,(R6및 R7은 각각 수소원자 또는 C1-C8알킬기를 나타낸다)이거나 또는 X 또는 Y가 Z와 함께 하나의 수소원자를 포함하는 5원환을 형성할 수도 있으며, Z는 질소원자, C-R8(여기서, R8은 수소원자, 할로알킬기 또는 X 또는 Y와 함께 하나의 산소원자를 함유하는 5원환을 형성할 수 있다)를 나타내며, 또한 L은 C1-C8의 알킬기, 알킬에테르기, 알릴기 또는 페닐기등의 이탈기를 나타낸다.Wherein A is a hydrogen atom, a C 1 -C 8 alkyl group or a phenyl group, and B and C are each independently a hydrogen atom, a halogen atom, a nitro group, or a phenyl group which may be substituted with a nitro group, a C 1 -C 8 alkyl group, C 1 -C 8 alkoxy group, halogenated alkyl group, CO 2 R (where R represents C 1 -C 8 alkyl group, aryl group or propargyl group), -CONR 1 R 2 (wherein R 1 is C 1 -C 8 alkyl group or phenyl group, R 2 represents a C 1 -C 8 alkyl group or R 1 and R 2 together represent — (CH 2 ) n —, —CH 2 CH 2 , —O—CH 2 CH 2 —, or —CH 2 CH 2 N (CH 3 ) CH 2 CH 2 —, where n represents 4, 5 or 6, -S (O) mR 3 where R 3 is a C 1 -C 8 alkyl group, A phenyl group or an arylalkyl group, m represents 0, 1 or 2), -SO 2 R 4 R 5 (R 4 represents a C 1 -C 8 alkyl group, R 5 represents a C 1 -C 8 alkyl group or , Or R 4 , R 5 together are-(CH 2 ) p- , -CH 2 CH 2 -O-CH 2 CH 2 -or -CH 2 N (CH 3 ) Represents CH 2 CH 2- , where P represents 4, 5 or 6), D represents a hydrogen atom or a C 1 -C 8 alkyl group, X and Y independently represent a hydrogen atom, a halogen atom, C 1- C 8 alkyl group, C 1 -C 8 alkoxy, C 1 -C 8 alkoxyalkyl group, -CF 3 group, C 1 -C 8 haloalkyl group, alkylamino group, dialkylamino group, (R 6 and R 7 each represent a hydrogen atom or a C 1 -C 8 alkyl group) or X or Y may form a 5-membered ring containing one hydrogen atom together with Z, where Z is a nitrogen atom, CR 8 (wherein R 8 may form a hydrogen atom, a haloalkyl group or a 5-membered ring containing one oxygen atom together with X or Y), and L is an alkyl group, alkylether group of C 1 -C 8 Leaving groups such as an allyl group or a phenyl group.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019920023999A KR960007530B1 (en) | 1992-12-11 | 1992-12-11 | Process for preparation of sulfonilurea derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019920023999A KR960007530B1 (en) | 1992-12-11 | 1992-12-11 | Process for preparation of sulfonilurea derivatives |
Publications (2)
Publication Number | Publication Date |
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KR940014388A true KR940014388A (en) | 1994-07-18 |
KR960007530B1 KR960007530B1 (en) | 1996-06-05 |
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ID=19345310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920023999A KR960007530B1 (en) | 1992-12-11 | 1992-12-11 | Process for preparation of sulfonilurea derivatives |
Country Status (1)
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KR (1) | KR960007530B1 (en) |
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1992
- 1992-12-11 KR KR1019920023999A patent/KR960007530B1/en not_active Application Discontinuation
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KR960007530B1 (en) | 1996-06-05 |
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