KR940014349A - New 6-amino pyrimidine-4-thione derivatives and preparation method thereof - Google Patents

New 6-amino pyrimidine-4-thione derivatives and preparation method thereof Download PDF

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Publication number
KR940014349A
KR940014349A KR1019920024493A KR920024493A KR940014349A KR 940014349 A KR940014349 A KR 940014349A KR 1019920024493 A KR1019920024493 A KR 1019920024493A KR 920024493 A KR920024493 A KR 920024493A KR 940014349 A KR940014349 A KR 940014349A
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KR
South Korea
Prior art keywords
alkyl group
amino pyrimidine
hydrogen
formula
preparation
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Application number
KR1019920024493A
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Korean (ko)
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KR970008317B1 (en
Inventor
임종찬
김용주
여재홍
방찬식
우영민
양덕호
김삼식
김성겸
남기평
옥종화
이복만
Original Assignee
최근선
주식회사 럭키
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Priority to KR1019920024493A priority Critical patent/KR970008317B1/en
Publication of KR940014349A publication Critical patent/KR940014349A/en
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Publication of KR970008317B1 publication Critical patent/KR970008317B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Abstract

본 발명은 세팔로스포린계 항생제의 중간체로서 유용한 하기 일반식(Ⅰ)로 표시되는 6-아미노 피리미딘-4-티온 유도체에 관한 것이다.The present invention relates to a 6-amino pyrimidine-4-thione derivative represented by the following general formula (I) which is useful as an intermediate of cephalosporin-based antibiotics.

상기식에서, R1은 C1-4알킬기이며 ; R2는 수소 또는 C1-4알킬기이다.Wherein R 1 is a C 1-4 alkyl group; R 2 is hydrogen or a C 1-4 alkyl group.

Description

신규 6-아미노 피리미딘-4-티온 유도체 및 이의 제조방법Novel 6-amino pyrimidine-4-thione derivatives and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (5)

하기 일반식(Ⅰ)로 표시되는 6-아미노 피리미딘-4-티온 유도체6-amino pyrimidine-4-thione derivative represented by the following general formula (I) 상기식에서, R1은 C1-4알킬기이며 ; R2는 수소 또는 C1-4알킬기이다.Wherein R 1 is a C 1-4 alkyl group; R 2 is hydrogen or a C 1-4 alkyl group. 제 1 항에 있어서, R1이 메틸기 또는 에틸기이고, R2가 수소 또는 메틸기인 일반식(Ⅰ)화합물.The compound of formula (I) according to claim 1, wherein R 1 is a methyl group or an ethyl group, and R 2 is a hydrogen or methyl group. 하기 일반식(Ⅲ)의 화합물을 알킬화제와 반응시켜 일반식(Ⅱ)의 화합물을 합성한 후, 이를 알킬기 금속 하이드로티옥사이드(M-SH)로 치환 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 신규 6-아미노 피리미딘-4-티온 유도체의 제조방법.A compound of formula (II) is synthesized by reacting a compound of formula (III) with an alkylating agent, and then substituted with an alkyl group metal hydrothioxide (M-SH). Process for the preparation of the novel 6-amino pyrimidine-4-thione derivatives. 상기식에서, R1은 C1-4알킬기이고; R2는 수소 또는 C1-4알킬기이며; X는 할로겐 원자 또는 설페이트 같은 산잔기를 나타내며; M은 리튬, 나트륨 또는 칼륨이다.Wherein R 1 is a C 1-4 alkyl group; R 2 is hydrogen or a C 1-4 alkyl group; X represents an acid residue such as a halogen atom or sulfate; M is lithium, sodium or potassium. 제 3 항에 있어서, 알킬화제가 메틸요오다이드, 에틸요오다이드, 디메틸설페이트 또는 디에틸설페이트임을 특징으로 하는 방법.4. The process of claim 3 wherein the alkylating agent is methyl iodide, ethyl iodide, dimethylsulfate or diethylsulfate. 제 3 항에 있어서, 치환반응이 50 내지 120℃의 온도에서 수행함을 특징으로 하는 방법.The method of claim 3, wherein the substitution is carried out at a temperature of 50 to 120 ℃. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019920024493A 1992-12-16 1992-12-16 Novel 6-aminopyrimidin-4-thione derivatives and process for preparing them KR970008317B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019920024493A KR970008317B1 (en) 1992-12-16 1992-12-16 Novel 6-aminopyrimidin-4-thione derivatives and process for preparing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019920024493A KR970008317B1 (en) 1992-12-16 1992-12-16 Novel 6-aminopyrimidin-4-thione derivatives and process for preparing them

Publications (2)

Publication Number Publication Date
KR940014349A true KR940014349A (en) 1994-07-18
KR970008317B1 KR970008317B1 (en) 1997-05-23

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ID=19345776

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920024493A KR970008317B1 (en) 1992-12-16 1992-12-16 Novel 6-aminopyrimidin-4-thione derivatives and process for preparing them

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KR970008317B1 (en) 1997-05-23

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