KR940008680A - New anti-inflammatory analgesic gel preparation containing propionic acid nonsteroidal drug as an active ingredient - Google Patents

New anti-inflammatory analgesic gel preparation containing propionic acid nonsteroidal drug as an active ingredient Download PDF

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Publication number
KR940008680A
KR940008680A KR1019920020219A KR920020219A KR940008680A KR 940008680 A KR940008680 A KR 940008680A KR 1019920020219 A KR1019920020219 A KR 1019920020219A KR 920020219 A KR920020219 A KR 920020219A KR 940008680 A KR940008680 A KR 940008680A
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KR
South Korea
Prior art keywords
propionic acid
inflammatory analgesic
gel preparation
nonsteroidal anti
active ingredient
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Application number
KR1019920020219A
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Korean (ko)
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KR960000428B1 (en
Inventor
지상철
단현광
전홍원
Original Assignee
이금기
일동제약 주식회사
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Application filed by 이금기, 일동제약 주식회사 filed Critical 이금기
Priority to KR1019920020219A priority Critical patent/KR960000428B1/en
Publication of KR940008680A publication Critical patent/KR940008680A/en
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Publication of KR960000428B1 publication Critical patent/KR960000428B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 케토프로펜, 이브푸로펜, 플루르비프로펜, 나프록센, 페노푸로펜, 베녹사푸로펜, 인도프로펜, 피푸로펜, 카푸로펜, 옥사프로진,프라노푸로펜, 수푸로펜, 알미노푸로펜, 비치부펜 및 펜부펜등과 같은 프로피온산계 비스테로이드성 소염진통 약물을 유효성분으로 함유하고 플루로닉; 저급알코올, 프로필펜글르콜, 폴리에틸렌 글리콜 및 글레세린에서 선택된 1종 이상의 시약; 물 또는 완충액을 가하고 균질히 혼합하여 제조된 신규의 프로피온산계 비스테로이드성 소염진통 외용 겔제제에 관한 것이며, 본 발명의 외용 겔제제는 피부에 바르면 얇은 막을 형성한 플루로닉으로부터 약물이 서서히 방출되어 그 소염진통효과는 오랜동안 지속되며 그 효과도 대단히 좋으며, 위궤양형성 정도가 낮으며 매우 안정하다.The present invention is ketoprofen, ipurofene, flurbiprofen, naproxen, phenofurofen, benoxapurofen, indoprofen, pipeurofen, capurofen, oxaprozin, pranopurofen, supro Pluronic containing propionic acid-based nonsteroidal anti-inflammatory drugs, such as pen, aluminofurofen, beipbufen and penbufen, as an active ingredient; At least one reagent selected from lower alcohols, propylphenglycol, polyethylene glycol and glycerine; The present invention relates to a novel propionic acid-based nonsteroidal anti-inflammatory analgesic external gel preparation prepared by adding water or a buffer solution and homogeneously mixing. The external gel preparation of the present invention is slowly released from the pluronic film having a thin film when applied to the skin. The anti-inflammatory analgesic effect lasts for a long time, and the effect is very good.

Description

프로피온산계 비스테로이드성 약물을 유효성분으로 함유하는 신규 소염진통 외용 겔제제New anti-inflammatory analgesic gel preparation containing propionic acid nonsteroidal drug as an active ingredient

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

프로피온산계 비스테로이드성 소염진통 약물을 유효성분으로 함유하고 플루로닉; 저급알코올, 프로필렌글리콜, 폴리에틸렌글리콜 및 글리세린에서 선택된 1종 이상의 시약; 및 물 또는 완충액을 가하고 균질히 혼합하여 제조된 프로피온산계 비스테로이드성 소염진통 외용 겔제제.Pluronic containing propionic acid nonsteroidal anti-inflammatory drugs as an active ingredient; One or more reagents selected from lower alcohols, propylene glycol, polyethylene glycol and glycerin; And a propionic acid-based nonsteroidal anti-inflammatory analgesic external gel preparation prepared by adding water or a buffer and homogeneously mixing. 프로피온산계 비스테로이드성 소염진통 약물을 유효성분으로 함유하고 플루로닉; 저급알코올; 프로필렌글리콜, 폴리에틸렌글리콜 및 글리세린에서 선택된 1종 이상의 시약; 및 물 또는 완충액을 가하고 균질히 혼합하여 제조된 프로피온산계 비스테로이드성 소염진통 외용 겔제제.Pluronic containing propionic acid nonsteroidal anti-inflammatory drugs as an active ingredient; Lower alcohol; At least one reagent selected from propylene glycol, polyethylene glycol and glycerin; And a propionic acid-based nonsteroidal anti-inflammatory analgesic external gel preparation prepared by adding water or a buffer and homogeneously mixing. 제1항과 또는 제2항에서, 통상의 방부제 및 방향제에서 선택된 1종 이상의 시약을 더 가하고 균질히 혼합하여 제조된 프로피온산계 비스테로이드성 소염진통 외용 겔제제.A propionic acid-based nonsteroidal anti-inflammatory analgesic external gel preparation prepared according to claim 1 or 2, wherein the at least one reagent selected from conventional preservatives and fragrances is added and mixed homogeneously. 제1항과 또는 제2항에서, 프로피온산계 소염진통제로서 케토푸로펜, 이브루로펜, 플루르푸로펜, 나프록센, 페노루로펜, 베녹사푸로펜, 인도푸로펜, 피푸로펜, 비치부펜 및 펜부펜에서 선택된 1종 이상의 약물을 사용하여 제조된 프로피온산계 비스테로이드성 소염진통 외용 겔제제.The propionic acid-based anti-inflammatory analgesic agent according to claim 1 or 2, wherein ketopuropenne, ibrurophene, flufurofene, naproxen, phenourolopene, benoxapurophen, indofurofene, pipeurofen, and beibubufen And a propionic acid-based nonsteroidal anti-inflammatory analgesic external gel preparation prepared using at least one drug selected from fenbufen. 제1항과 또는 제2항에서, 사용된 프로피온산계 비스테로이드성 소염진통 약물이 pKa부근으로 pH를 조절하여 제조된 프로피온산계 비스테로이드성 소염진통 외용 겔제제.The propionic acid-based nonsteroidal anti-inflammatory analgesic external gel preparation of claim 1 or 2, wherein the propionic acid-based nonsteroidal anti-inflammatory analgesic drug used is prepared by adjusting the pH near pKa. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019920020219A 1992-10-30 1992-10-30 Process for preparing gel type preparation containing nonsteroidal anti-inflammatory drug KR960000428B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019920020219A KR960000428B1 (en) 1992-10-30 1992-10-30 Process for preparing gel type preparation containing nonsteroidal anti-inflammatory drug

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Application Number Priority Date Filing Date Title
KR1019920020219A KR960000428B1 (en) 1992-10-30 1992-10-30 Process for preparing gel type preparation containing nonsteroidal anti-inflammatory drug

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KR940008680A true KR940008680A (en) 1994-05-16
KR960000428B1 KR960000428B1 (en) 1996-01-06

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102577850B1 (en) * 2023-02-21 2023-09-13 국방과학연구소 Monolithic Flexure Hinge Mount for Optical section

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102577850B1 (en) * 2023-02-21 2023-09-13 국방과학연구소 Monolithic Flexure Hinge Mount for Optical section

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