KR940000466A - 4H, 6H-furo [3,4-C] isoxazole derivatives and preparation method thereof - Google Patents

Abstract

The present invention relates to a novel 4H, 6H-furo [3,4-c] isoxazole derivative represented by the following general formula (I) having bactericidal activity against phytopathogens and a method for producing the same.

Wherein R ¹ is a C ₁ to C ₆ alkyl group or a substituted phenyl group, R ² is a hydrogen atom or a C ₁ to C ₃ alkyl group, R ³ is a hydrogen atom, a C _{1 to} C ₄ alkyl group, a phenyl group, a halogen An phenyl group substituted with an atom, a phenyl group substituted with a halogen atom, an aldehyde group, a substituted methyl group of -CH ₂ -R ⁴ or an oxime group of -CH = N-OR ⁵ , wherein R ⁴ is a hydroxy group, an alkoxy group, 2-pyranyl jade It is a time period, an alkylcarbonyloxy group, a halogen atom, or an amine group, R <^4> is a hydrogen atom, a lower alkyl group, or a lower alkene group.

Description

4H, 6H-furo [3,4-c] isoxazole derivatives and preparation method thereof

Since this is an open matter, no full text was included.

Claims (9)

4H, 6H-furo [3,4-c] isoxazole derivative represented by the following general formula (I). Wherein R ¹ is a C ₁ to C ₆ alkyl group or a substituted phenyl group, R ² is a hydrogen atom or a C ₁ to C ₃ alkyl group, R ³ is a hydrogen atom, a C _{1 to} C ₄ alkyl group, a phenyl group, a halogen An phenyl group substituted with an atom, a phenyl group substituted with a halogen atom, an aldehyde group, a substituted methyl group of -CH ₂ -R ₄ or an oxime group of -CH = N-OR ⁵ , wherein R ⁴ is a hydroxy group, an alkoxy group, 2-pyranyl jade It is a time period, an alkylcarbonyloxy group, a halogen atom, or an amine group, R <^5> is a hydrogen atom, a lower alkyl group, or a lower alkene group. The method of claim 1. R ¹ is a fluoro group or an isopropyl group, or a phenyl group substituted with a chlorine atom, a fluorine atom, a methyl group or a trifluoromethyl group. 4H, 6H-furo [3,4-c] isoxazole derivative. The 4H, 5H-furo [3,4-c] isoxazole derivative according to claim 1, wherein R ² is a hydrogen atom or a methyl group. R ³ is a hydrogen atom, a methyl group, an ethyl group, a phenyl group, a phenyl group substituted with a chlorine atom, an aldehyde group, a substituted methyl group of -CH ₂ R ⁴ , or an oxime group of -CH = N-OR ⁵ . 4H, 6H-furo [3, 4-c] isoxazole derivatives. The 4H, 6H-furo [3,4-] according to claim 4, wherein R ⁴ is a hydroxy group, a methoxy group, a 2-pyridyloxy group, a methylcarbonyloxy group, a chlorine atom, a bromine atom, or a morpholic group. c] isoxazole derivatives. The 4H, 6H-furo [3,4-c] isoxazole derivative according to claim 4, wherein R ⁵ is a hydrogen atom, a methyl group, an ethyl group or an allyl group. A horticultural germicide composition comprising a 4H, 6H-furo [3,4-c] isoxazole derivative represented by the following general formula (I) as an active ingredient and mixed with a solid or liquid carrier usable for farm horticulture. Wherein R ¹ , R ² and R ³ are as defined in general formula (I) of claim ¹ , respectively. The nitroolefin compound represented by the following general formula (II) and the alcohol derivative represented by the following general formula (III) are reacted in the presence of a base to prepare a nitro compound represented by the following general formula (IV), which is then dehydrated. A method for producing a 4H, 6H-furo [3,4-c] isoxazole derivative represented by the following general formula (I) by cyclization. Wherein R ¹ , R ² and R ³ are each as defined in general formula (I) of claim 1 above. Nitro compound represented by the following general formula (IV) which is an intermediate of the 4H, 6H-furo [3,4-c] isoxazole derivative of the following general formula (I) In the formulas, R ¹ , R ² and R ³ are as defined in general formula (I) of claim ¹ , respectively. ※ Note: The disclosure is based on the initial application.