KR930700444A - Dihydropyridine Compound and Method for Preparing the Same - Google Patents

Dihydropyridine Compound and Method for Preparing the Same

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Publication number
KR930700444A
KR930700444A KR1019920702389A KR920702389A KR930700444A KR 930700444 A KR930700444 A KR 930700444A KR 1019920702389 A KR1019920702389 A KR 1019920702389A KR 920702389 A KR920702389 A KR 920702389A KR 930700444 A KR930700444 A KR 930700444A
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South Korea
Prior art keywords
group
dihydropyridine compound
same
dihydropyridine
acid addition
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KR1019920702389A
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Korean (ko)
Other versions
KR960001201B1 (en
Inventor
기요다까 이또오
히데까즈 아까마쓰
게이조오 이노우에
오사무 오노무라
다께시 하마다니
요오이찌로오 우에다
기미오 에스미
Original Assignee
후지야마 아끼라
후지사와 야꾸힌 고오교오 가부시끼가이샤
고지마 아끼로오
다이셀 가가꾸 고오교오 가부시끼가이샤
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Application filed by 후지야마 아끼라, 후지사와 야꾸힌 고오교오 가부시끼가이샤, 고지마 아끼로오, 다이셀 가가꾸 고오교오 가부시끼가이샤 filed Critical 후지야마 아끼라
Publication of KR930700444A publication Critical patent/KR930700444A/en
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Publication of KR960001201B1 publication Critical patent/KR960001201B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.No content.

Description

디히드로피리딘 화합물 및 그 제조방법Dihydropyridine Compound and Method for Preparing the Same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (19)

다음 일반식Following formula (식에서, W는 시아노 또는 할로알킬기(탄소원자수 1내지 6의 알킬기)를 나타내며, R1은 탄소원자수 1내지 6의 알킬기를 나타내며, R2및 R3는 동일하거나 다를 수도 있으며, 각기 탄소원자수 1내지 6의 알킬기를 나타내고, X및 Y는 서로 동일하거나 다를 수도 있으며, 각기 수소원자, 탄소원자수 1내지 6의 알킬기, 할로겐 원자 또는 니트로기를 나타내며, Ar은 임의로 치환된 아릴기를 나타내며, A는 탄소 원자수 1내지 10의 알킬렌기 또는 그것의 산부가염을 나타낸다)의 디히드로피리딘 화합물.Wherein W represents a cyano or haloalkyl group (alkyl group having 1 to 6 carbon atoms), R 1 represents an alkyl group having 1 to 6 carbon atoms, R 2 and R 3 may be the same or different, and each has a carbon atom number 1 to 6 alkyl groups, X and Y may be the same or different from each other, each represent a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a halogen atom or a nitro group, Ar represents an optionally substituted aryl group, A is carbon Dihydropyridine compound having 1 to 10 alkylene groups or acid addition salts thereof. 제1항에 있어서, X 및/또는 Y가 할로겐 원자일 때 상기 할로겐 원자가 불소, 염소 또는 브롬인 것을 특징으로 하는 디히드로피리딘 화합물.The dihydropyridine compound according to claim 1, wherein when the X and / or Y is a halogen atom, the halogen atom is fluorine, chlorine or bromine. 제1항 또는 제2항에 있어서, 상기 산부가염이 염산염 또는 황산염인 것을 특징으로 하는 디히드로피리딘 화합물.The dihydropyridine compound according to claim 1 or 2, wherein the acid addition salt is a hydrochloride salt or a sulfate salt. 제1항 또는 제2항에 있어서, 상기 산부가염이 옥살산염, 락트산염, 숙신산, 타르타르산염, 말레산염, 푸마르산염, 아세트산염, 살리실산염, 시트르산염, 벤조산염, 베타 나프토산염, 아디프산염, 메탄술폰산염, 벤젠술폰산염 또는 p-톨루엔술폰산염인 것을 특징으로 하는 디히드로피리딘 화합물.The acid addition salt according to claim 1 or 2, wherein the acid addition salt is oxalate, lactate, succinic acid, tartarate, maleate, fumarate, acetate, salicylate, citrate, benzoate, beta naphthoate, adipic. Dihydropyridine compounds, characterized in that it is an acid salt, methane sulfonate, benzene sulfonate or p-toluene sulfonate. 다음 일반식Following formula (식에서, W, R1, R2, R3, A, X 및 Y는 특허청구의 범위 제1항에 규정된 바와 동일하다)의 아민과 다음 일반식In which W, R 1 , R 2 , R 3 , A, X and Y are the same as defined in claim 1, and the general formula (식에서, Ar는 특허청구의 범위 제1항에 규정된 바와 동일하며, L은 적당한 이탈기(반응성 작용기)를 나타낸다)의 에폭시드 또는 알코올 유도체의 반응으로 이루어지는 것을 특징으로 하는 특허청구의 범위 제1항에 규정된 디히드로피리딘 화합물의 제조방법.Wherein Ar is the same as defined in claim 1 and L represents the appropriate leaving group (reactive functional group). Process for the preparation of dihydropyridine compound as defined in claim 1. 다음 일반식Following formula (식에서, W, R1, R2, R3, A, X 및 Y는 특허청구의 범위 제1항에 규정된 바와 동일하며, Z는 적당한 이탈기(반응성 작용기)를 나타낸다)의 디히드로피리딘 유도체와 다음 일반식(Wherein W, R 1 , R 2 , R 3 , A, X and Y are as defined in claim 1 and Z represents a suitable leaving group (reactive functional group)) Derivatives and the following general formula (식에서, Ar는 특허청구의 범위 제1항에 규정된 바와 동일하다)의 아민의 반응에 의해 이루어지는 것을 특징으로 하는 특허청구의 범위 제1항에 규정된 디히드로 피리딘 화합물의 제조방법.A process for producing the dihydropyridine compound as defined in claim 1, wherein the compound is formed by the reaction of an amine (wherein Ar is the same as defined in claim 1). 제5항 또는 제6항에 있어서, 상기 이탈기(반응성 작용기)는 메탄술포닐옥시, 벤젠술포닐옥시, p-톨루엔술포닐옥시, m-니트로벤젠술포닐옥시, p-니트로벤젠술포닐옥시, 염소, 브롬 또는 요오드기인 것을 특징으로 하는 디히드로피리딘 화합물의 제조방법.The leaving group (reactive functional group) according to claim 5 or 6, wherein methanesulfonyloxy, benzenesulfonyloxy, p-toluenesulfonyloxy, m-nitrobenzenesulfonyloxy, p-nitrobenzenesulfonyloxy Method for producing a dihydropyridine compound, characterized in that the chlorine, bromine or iodine group. W가 할로알킬기일 때 할로알킬기가 트리플루오로메틸인 것을 특징으로 하는 특허청구의 범위 제1항 내지 제7항중 어느 한항에 규정된 바의 디히드로피리딘 화합물.A dihydropyridine compound as defined in any of claims 1 to 7 wherein the haloalkyl group is trifluoromethyl when W is a haloalkyl group. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019920702389A 1991-01-30 1992-01-28 Dihydro-pyridine compounds and the preparation thereof KR960001201B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9102031 1991-01-30
GB919102031A GB9102031D0 (en) 1991-01-30 1991-01-30 Dihydropyridine compounds,and process for their preparation
GB9102031.3 1991-01-30
PCT/JP1992/000076 WO1992013839A1 (en) 1991-01-30 1992-01-28 Dihydropyridine compounds, and process for their preparation

Publications (2)

Publication Number Publication Date
KR930700444A true KR930700444A (en) 1993-03-15
KR960001201B1 KR960001201B1 (en) 1996-01-24

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EP (1) EP0522176A1 (en)
JP (1) JPH06500336A (en)
KR (1) KR960001201B1 (en)
CA (1) CA2078338A1 (en)
GB (1) GB9102031D0 (en)
WO (1) WO1992013839A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08502038A (en) * 1992-07-28 1996-03-05 藤沢薬品工業株式会社 1,4-Dihydropyridine derivative having antihypertensive effect and method for producing the same
WO1995020576A1 (en) * 1994-01-29 1995-08-03 Fujisawa Pharmaceutical Co., Ltd. 4-(2-(3-aryloxy-2-hydroxypropylamino alkyloxy)-5-nitrophenyl)-1,4-dihydropyridines as antihypertensive agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6112662A (en) * 1984-06-28 1986-01-21 Yamanouchi Pharmaceut Co Ltd Dihydropyridine derivative and its production
NO854021L (en) * 1984-10-26 1986-04-28 Bayer Ag 1,4-DIHYDROPYRIDINE HYDROXYAMINES AND PROCEDURES FOR PREPARING THEREOF.
GB8503425D0 (en) * 1985-02-11 1985-03-13 Ici Plc Alkanolamine derivatives
JPH01151554A (en) * 1985-05-30 1989-06-14 Yamanouchi Pharmaceut Co Ltd Novel production of 1,4-dihydropyridine derivative
DE3531498A1 (en) * 1985-09-04 1987-03-05 Bayer Ag DIHYDROPYRIDIN-2-HYDROXYAMINE, METHOD FOR THE PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
KR960001201B1 (en) 1996-01-24
EP0522176A1 (en) 1993-01-13
WO1992013839A1 (en) 1992-08-20
GB9102031D0 (en) 1991-03-13
JPH06500336A (en) 1994-01-13
CA2078338A1 (en) 1992-07-31

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