KR930023347A - Racemization of Octahydroisoquinoline Optically Active Compounds - Google Patents

Racemization of Octahydroisoquinoline Optically Active Compounds Download PDF

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Publication number
KR930023347A
KR930023347A KR1019920007546A KR920007546A KR930023347A KR 930023347 A KR930023347 A KR 930023347A KR 1019920007546 A KR1019920007546 A KR 1019920007546A KR 920007546 A KR920007546 A KR 920007546A KR 930023347 A KR930023347 A KR 930023347A
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KR
South Korea
Prior art keywords
hydrogen
heating
racemization
hydrogen pressure
octahydroisoquinoline
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KR1019920007546A
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Korean (ko)
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KR960011374B1 (en
Inventor
김철
권용철
Original Assignee
김두하
주식회사 제철화학
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Priority to KR1019920007546A priority Critical patent/KR960011374B1/en
Publication of KR930023347A publication Critical patent/KR930023347A/en
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Publication of KR960011374B1 publication Critical patent/KR960011374B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

본 발명은 다음의 일반식(Ⅰ)로 표시되는 옥타하이드로 이소퀴놀린 화합물을 용매에 녹인 다음 수소가압하에 라니 구리 촉매 존재하에서 가열하여서 그의 라세미체로 전환시키는 방법을 제공하는 것으로서, 본 발명에 다르면 라세미화율이 향상될 뿐 아니라 반응 후 촉매활성이 거의 저하되지 않아 촉매를 재사용할 수 있고 라니 구리촉매 자체가 비교적 저가이고 제조하기 용이하다는 경제적인 잇점이 있다.The present invention provides a method of dissolving an octahydro isoquinoline compound represented by the following general formula (I) in a solvent and then heating it in the presence of a Raney copper catalyst under hydrogen pressure, and converting the same into a racemate thereof. Not only is the racemization rate improved, but the catalytic activity is hardly reduced after the reaction, so that the catalyst can be reused, and the Raney copper catalyst itself is economical in terms of relatively low cost and easy to manufacture.

상기 식에서, R1은 수소 또는 탄소수 1 내지 8의 탄화수소기이고, R2는 수소 또는 저급 알킬기이다.In the above formula, R 1 is hydrogen or a hydrocarbon group of 1 to 8 carbon atoms, and R 2 is hydrogen or lower alkyl group.

Description

옥타하이드로이소퀴놀린계 광학활성 화합물의 라세미화(racemization) 방법Racemization of Octahydroisoquinoline Optically Active Compounds

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (7)

다음의 일반식(Ⅰ)로 표시되는 옥타하이드로 이소퀴놀린 화합물을 용매에 녹인 다음 수소가압하에 라니 구리 촉매 존재하에서 가열하여서 그의 라세미체로 전환시키는 방법.A method of dissolving an octahydro isoquinoline compound represented by the following general formula (I) in a solvent and then heating it in the presence of a Raney copper catalyst under hydrogen pressure to convert it to a racemate thereof. 상기 식에서, R1은 수소 또는 탄소수 1 내지 8의 탄화수소기이고, R2는 수소 또는 저급 알킬기이다.In the above formula, R 1 is hydrogen or a hydrocarbon group of 1 to 8 carbon atoms, and R 2 is hydrogen or lower alkyl group. 제1항에 있어서, 60 내지 150℃의 온도로 가열하는 것인 방법.The method of claim 1, wherein the heating is to a temperature of 60 to 150 ° C. 3. 제2항에 있어서, 95 내지 135℃의 온도로 가열하는 것인 방법.The method of claim 2, wherein the heating is to a temperature of 95 to 135 ° C. 4. 제1항에 있어서, 수소압력을 200 내지 1200psig로 하는 것인 방법.The method of claim 1 wherein the hydrogen pressure is between 200 and 1200 psig. 제4항에 있어서, 수소압력을 300 내지 950psig로 하는 것인 방법.The method of claim 4, wherein the hydrogen pressure is between 300 and 950 psig. 제1항에 있어서, 반응 용매로서 톨루엔, 크실렌, 메탄올 또는 에탄올을 사용하는 것인 방법.The method of claim 1, wherein toluene, xylene, methanol or ethanol is used as the reaction solvent. 제6항에 있어서, 반응 용매로서 톨루엔을 사용하는 것인 방법.The method of claim 6, wherein toluene is used as the reaction solvent. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019920007546A 1992-05-02 1992-05-02 Racemization of octahydroisoquinoline KR960011374B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019920007546A KR960011374B1 (en) 1992-05-02 1992-05-02 Racemization of octahydroisoquinoline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019920007546A KR960011374B1 (en) 1992-05-02 1992-05-02 Racemization of octahydroisoquinoline

Publications (2)

Publication Number Publication Date
KR930023347A true KR930023347A (en) 1993-12-18
KR960011374B1 KR960011374B1 (en) 1996-08-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920007546A KR960011374B1 (en) 1992-05-02 1992-05-02 Racemization of octahydroisoquinoline

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Publication number Publication date
KR960011374B1 (en) 1996-08-22

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