KR930012004A - Method for preparing sustained release formulation of diltiazem - Google Patents
Method for preparing sustained release formulation of diltiazem Download PDFInfo
- Publication number
- KR930012004A KR930012004A KR1019910023465A KR910023465A KR930012004A KR 930012004 A KR930012004 A KR 930012004A KR 1019910023465 A KR1019910023465 A KR 1019910023465A KR 910023465 A KR910023465 A KR 910023465A KR 930012004 A KR930012004 A KR 930012004A
- Authority
- KR
- South Korea
- Prior art keywords
- water
- cellulose
- sustained release
- release formulation
- granules
- Prior art date
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
본 발명은 딜티아젬 또는 염산 딜티아젬의 활성물질 중합체 및 지방산을 이용하여 매트릭스 정체를 제조함에 있어서, 활성물질과 수용성 중합체와 아라비아 고무가루를 혼합하여 일차과립을 제조한 후, 활성물질과 불수용성 중합체와 지방산을 혼합하여 2차과립을 제조하여 일차 과립과 2차 과립을 혼합하여 압축타정하는 것을 특징으로 하는 서방출형 제형의 제조방법에 관한 것이며, 본 발명의 방법에 의하여 제조된 딜티아젬의 서방출형제제는 경구투여시에 위, 장관에애에서 장시간에 걸쳐서 약물이 고르게 발출되는 신규의 제형이다.The present invention is to prepare a matrix granules using the active material polymer and fatty acid of diltiazem or diltiazem hydrochloride, after preparing the primary granules by mixing the active material, water-soluble polymer and gum arabic, The present invention relates to a method for preparing a sustained release formulation comprising mixing a water-soluble polymer and a fatty acid to prepare secondary granules, followed by compression compression by mixing the primary granules and the secondary granules. GEM's sustained release formulation is a novel formulation that evenly releases the drug over long periods of time in the stomach and intestinal tract during oral administration.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019910023465A KR930012004A (en) | 1991-12-19 | 1991-12-19 | Method for preparing sustained release formulation of diltiazem |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019910023465A KR930012004A (en) | 1991-12-19 | 1991-12-19 | Method for preparing sustained release formulation of diltiazem |
Publications (1)
Publication Number | Publication Date |
---|---|
KR930012004A true KR930012004A (en) | 1993-07-20 |
Family
ID=67356800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910023465A KR930012004A (en) | 1991-12-19 | 1991-12-19 | Method for preparing sustained release formulation of diltiazem |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR930012004A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100821879B1 (en) * | 2006-12-29 | 2008-04-16 | 김한기 | Mosquito repellent composition |
-
1991
- 1991-12-19 KR KR1019910023465A patent/KR930012004A/en not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100821879B1 (en) * | 2006-12-29 | 2008-04-16 | 김한기 | Mosquito repellent composition |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |