KR930012004A - Method for preparing sustained release formulation of diltiazem - Google Patents

Method for preparing sustained release formulation of diltiazem Download PDF

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Publication number
KR930012004A
KR930012004A KR1019910023465A KR910023465A KR930012004A KR 930012004 A KR930012004 A KR 930012004A KR 1019910023465 A KR1019910023465 A KR 1019910023465A KR 910023465 A KR910023465 A KR 910023465A KR 930012004 A KR930012004 A KR 930012004A
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KR
South Korea
Prior art keywords
water
cellulose
sustained release
release formulation
granules
Prior art date
Application number
KR1019910023465A
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Korean (ko)
Inventor
류길수
이정상
백승재
Original Assignee
하기주
주식회사 코오롱
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 하기주, 주식회사 코오롱 filed Critical 하기주
Priority to KR1019910023465A priority Critical patent/KR930012004A/en
Publication of KR930012004A publication Critical patent/KR930012004A/en

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 딜티아젬 또는 염산 딜티아젬의 활성물질 중합체 및 지방산을 이용하여 매트릭스 정체를 제조함에 있어서, 활성물질과 수용성 중합체와 아라비아 고무가루를 혼합하여 일차과립을 제조한 후, 활성물질과 불수용성 중합체와 지방산을 혼합하여 2차과립을 제조하여 일차 과립과 2차 과립을 혼합하여 압축타정하는 것을 특징으로 하는 서방출형 제형의 제조방법에 관한 것이며, 본 발명의 방법에 의하여 제조된 딜티아젬의 서방출형제제는 경구투여시에 위, 장관에애에서 장시간에 걸쳐서 약물이 고르게 발출되는 신규의 제형이다.The present invention is to prepare a matrix granules using the active material polymer and fatty acid of diltiazem or diltiazem hydrochloride, after preparing the primary granules by mixing the active material, water-soluble polymer and gum arabic, The present invention relates to a method for preparing a sustained release formulation comprising mixing a water-soluble polymer and a fatty acid to prepare secondary granules, followed by compression compression by mixing the primary granules and the secondary granules. GEM's sustained release formulation is a novel formulation that evenly releases the drug over long periods of time in the stomach and intestinal tract during oral administration.

Description

딜티아젬의 서방출성(徐放出性) 제형의 제조방법Method for preparing sustained release formulation of diltiazem

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (5)

활성물질인 딜티아젬 또는 염산 딜티아젬을 수용성, 불수용성 중합체 및 지방산을 이용하여 매트릭스 정제를 제조함에 있어서, 반량의 활성물질과 수용성 중합체 및 아라비아고무가루를 혼합하여 일차과립을 제조하고, 남은 반량의 활성물질과 불수용성 중합체, 지방산을 혼합하여 이차과립을 제조하며, 일차과립과 이차과립을 혼합하여 압축타정함을 특징으로 하는 서방출성 제형의 제조방법.In preparing a matrix tablet of the active substance diltiazem or diltiazem hydrochloride using water-soluble, water-insoluble polymers and fatty acids, primary granules are prepared by mixing half the amount of active substance, water-soluble polymer and gum arabic powder. A method for producing a sustained release formulation, characterized in that the secondary granules are prepared by mixing a half amount of the active substance, a water-insoluble polymer and a fatty acid, and compression compression by mixing the primary granules and the secondary granules. 제1항에 있어서 수용서 중합체는 폴리비닐 알코올, 폴리비닐 피롤리돈, 메틸 셀룰로즈, 하이드록시프로필 셀룰로즈, 하이드록시프로필에틸 세룰로즈, 하이드록시에틸 셀룰로즈, 프로필렌글리콜 또는 그 혼합물을 사용함을 특징으로 하는 서방출성 제형의 제조방법.The method of claim 1, wherein the acceptor polymer is characterized in that polyvinyl alcohol, polyvinyl pyrrolidone, methyl cellulose, hydroxypropyl cellulose, hydroxypropylethyl cellulose, hydroxyethyl cellulose, propylene glycol, or mixtures thereof. Process for the preparation of a sustained release formulation. 제1항에 있어서 불수용성 중합체는 에틸 세룰로저, 프로필 세룰로즈, 세룰로즈 아세테이트, 세룰로즈 프로피오네이트, 폴리에틸렌, 폴리비닐 클로라이드,폴리프로필렌,폴리메틸 아크릴레이트, 폴리이소부틸 아크릴레이트, 폴리우레탄 또는 그 혼합물을 사용함을 특징으로 하는 서방출성 제형의 제조방법.The water-insoluble polymer of claim 1 is ethyl cellulose, propyl cellulose, cellulose acetate, cellulose propionate, polyethylene, polyvinyl chloride, polypropylene, polymethyl acrylate, polyisobutyl acrylate, polyurethane or Method for producing a sustained release formulation characterized in that the mixture is used. 제1항에 있어서 지방산 스테아린산,팔미틴산, 라우르산, 엘레오스테아린산임을 특징으로 하는 서방출성 제형의 제조방법.The method for preparing a sustained release formulation according to claim 1, which is a fatty acid stearic acid, palmitic acid, lauric acid or eleostearic acid. 제1항에 있어서 불수용성 중합체 100중량부에 대해 아라비아고무가루를 40~50중량부 사용함을 특징으로 하는 서방출성 제형의 제조방법.The method of claim 1, wherein 40 to 50 parts by weight of gum arabic is used per 100 parts by weight of the water-insoluble polymer. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019910023465A 1991-12-19 1991-12-19 Method for preparing sustained release formulation of diltiazem KR930012004A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019910023465A KR930012004A (en) 1991-12-19 1991-12-19 Method for preparing sustained release formulation of diltiazem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019910023465A KR930012004A (en) 1991-12-19 1991-12-19 Method for preparing sustained release formulation of diltiazem

Publications (1)

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KR930012004A true KR930012004A (en) 1993-07-20

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KR1019910023465A KR930012004A (en) 1991-12-19 1991-12-19 Method for preparing sustained release formulation of diltiazem

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100821879B1 (en) * 2006-12-29 2008-04-16 김한기 Mosquito repellent composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100821879B1 (en) * 2006-12-29 2008-04-16 김한기 Mosquito repellent composition

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