KR920700014A - Non-Invasive Blood Glucose Testing Apparatus and Method - Google Patents

Abstract

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Description

Non-Invasive Blood Glucose Testing Apparatus and Method

As this is a public information case, the full text was not included.

1 is a schematic cross-sectional view of a non-invasive glucose test method of the present invention.

2 is a schematic cross-sectional view of a non-invasive glucose test method of the present invention using a rate controlling membrane.

3 is a cross-sectional view of the device as far as possible within the scope of the present invention.

Claims (77)

A certain amount of glucose receiving medium consisting of a penetration enhancer capable of enhancing glucose permeability through the epithelial membrane; A device for testing non-invasive blood glucose, comprising means for supporting a glucose soluble medium, and means for temporarily positioning a glucose soluble medium relative to the epithelium. The device of claim 1, wherein the means for supporting the glucose soluble medium comprises a housing therein and a housing defining an opening to the accommodation chamber. 3. The device of claim 2, further comprising a handle attached to the housing that facilitates positioning and removal of the device relative to the mucosa. 3. The device of claim 2, further comprising means for accessing the receiving chamber such that the glucose soluble medium can be introduced into or removed from the receiving chamber while the housing mucosa is located. 2. The device of claim 1, wherein the means for supporting the glucose soluble medium and the means for temporarily positioning the glucose soluble medium relative to the mucosa are comprised of a hydrogel. The device of claim 1 wherein the permeation enhancer consists of natural bile salts. The device of claim 1, wherein the glucose soluble medium consists of water. The device of claim 1, wherein the glucose medium consists of cream. The device of claim 1, wherein the glucose aqueous medium consists of a suspension. The device of claim 1, wherein the glucose soluble medium consists of a fluid. The device of claim 1, wherein the glucose water soluble medium consists of a semisolid composition. The device of claim 1, wherein the glucose soluble medium consists of a composition capable of reacting with glucose to form a substantially insoluble product. The device of claim 1, further comprising means for adjusting glucose permeation rate to obtain a corrected rate of permeation despite differences in glucose permeation with patient and time. Non-invasive blood glucose, characterized in that it comprises a certain amount of glucose soluble medium consisting of a permeation enhancer capable of increasing glucose permeability through the mucosa, means for supporting the glucose soluble medium, and means for temporarily positioning the glucose soluble medium relative to the mucosa. Inspection device. 15. The device of claim 14, wherein the means for supporting the glucose soluble medium comprises a housing therein and a housing defining an opening to the accommodation chamber. 16. The device of claim 15, further comprising a handle attached to the housing that facilitates positioning and removal of the device relative to the mucosa. 16. The device of claim 15, further comprising means for accessing the storage chamber so that the glucose soluble medium can be introduced into or removed from the storage chamber while the housing is located on the mucosa. 15. The device of claim 14, wherein the means for supporting the glucose soluble medium and the means for temporarily positioning the glucose soluble medium relative to the mucosa consist of a hydrogel. 19. The device of claim 18, wherein the hydrogel consists of hydroxypropylcellulose. 19. The device of claim 18, wherein the hydrogel consists of carbopul. 15. The device of claim 14, wherein the permeation enhancer consists of natural bile salts. 15. The device of claim 14, wherein the permeation enhancer consists of sodium chorate. 15. The device of Claim 14, wherein the permeation enhancer consists of sodium dodecyl sulfate. 15. The device of claim 14, wherein the permeation enhancer consists of sodium deoxycholate. 15. The device of claim 14, wherein the permeation enhancer consists of taurodeoxycholic acid salt. 15. The device of claim 14, wherein the penetration enhancer consists of sodium glycocholate. 15. The device of claim 14, wherein the permeation enhancer consists of fatty acids. 15. The device of claim 14, wherein the permeation enhancer consists of saturated fatty acids. 15. The device of claim 14, wherein the permeation enhancer consists of unsaturated fatty acids. 15. The device of claim 14, wherein the permeation enhancer consists of a surfactant. 15. The device of claim 14, wherein the permeation enhancer consists of an ionic surfactant. 15. The device of claim 14, wherein the permeation enhancer consists of a nonionic surfactant. 15. The device of claim 14, wherein the permeation enhancer consists of a synthetic permeation enhancer. 15. The device of claim 14, wherein the glucose soluble medium consists of water. 15. The device of claim 14, wherein the glucose soluble medium consists of cream. 15. The device of claim 14, wherein the glucose soluble medium consists of a suspension. 15. The device of claim 14, wherein the glucose soluble medium consists of a fluid. 15. The device of claim 14, wherein the glucose soluble medium consists of a semisolid composition. 15. The device of claim 14, wherein the glucose soluble medium consists of a composition capable of reacting with glucose to form a substantially insoluble product. 15. The device of claim 14, further comprising glucose transmission rate adjusting means to obtain a corrected rate of transmission despite differences in glucose transmission over time with the patient. Non-invasive blood glucose comprising a certain amount of glucose soluble medium consisting of a permeation enhancer capable of increasing glucose permeability through the skin, means for supporting the glucose soluble medium, and means for temporarily positioning the glucose soluble medium against the skin. Inspection device. 42. The device of claim 41, wherein the means for supporting the glucose soluble medium comprises a housing therein and a housing defining an opening to the accommodation chamber. 43. The device of claim 42, further comprising means for accessing the storage chamber so that the glucose soluble medium can be introduced into or removed from the storage chamber while positioned in the housing skin. 42. The device of claim 41, wherein the permeation enhancer consists of natural bile salts. 42. The device of claim 41, wherein the permeation enhancer consists of DMSO. 42. The device of claim 41, wherein the permeation enhancer consists of ethanol. 42. The device of claim 41, wherein the permeation enhancer consists of fatty acids. 42. The device of claim 41, wherein the permeation enhancer consists of a surfactant. 42. The device of claim 41, wherein the permeation enhancer consists of a synthetic permeation enhancer. 42. The device of Claim 41, wherein the glucose soluble medium consists of water. 42. The device of claim 41, wherein the glucose soluble medium consists of cream. 42. The device of claim 41, wherein the glucose aqueous medium consists of a suspension. 42. The device of claim 41, wherein the glucose soluble medium consists of a fluid. 42. The device of claim 41, wherein the glucose water soluble medium consists of a semisolid composition. 42. The device of Claim 41, wherein the glucose soluble medium consists of a composition capable of reacting with glucose to form a substantially insoluble product. 42. The device of claim 41, further comprising means for adjusting glucose transmission rate to obtain a corrected rate of transmission despite differences in glucose transmission over time with the patient. A certain amount of glucose water-soluble medium in the interior of the interior of the interior of the interior of the interior of the accommodation chamber, the housing defining an opening therein and the housing defining a permeation enhancer capable of increasing glucose permeability through the epithelium; And means for temporarily positioning the housing in the epithelium so that the opening to the accommodation chamber is overlying the epithelium. 58. The device of claim 57, wherein the glucose soluble medium consists of water. 59. The device of claim 57, wherein the glucose soluble medium consists of a hydrogel. 59. The device of claim 57, wherein the glucose water soluble medium consists of a semisolid composition. 58. The device of claim 57, wherein the glucose soluble medium consists of a composition capable of reacting with glucose to form a substantially insoluble product. 59. The device of claim 57, further comprising means for adjusting the glucose transmission rate to obtain a corrected rate of transmission despite differences in glucose permeability over time with the patient. 59. The device of claim 57, wherein the permeation enhancer consists of natural bile salts. 59. The device of claim 57, wherein the permeation enhancer consists of a synthetic permeation enhancer. 59. The apparatus of claim 57, further comprising means for accessing the chamber so that the glucose soluble medium can be introduced into or removed from the chamber while the housing is located in the epithelium. 59. The device of claim 57, wherein the epithelium consists of mucosa. 59. The device of claim 57, wherein the epithelium is made of skin. (a) a permeation enhancer capable of increasing glucose permeability through the epithelial membrane, the method comprising obtaining a certain amount of glucose soluble medium supported by the support material; (b) temporarily positioning a glucose soluble medium relative to the epithelium; And (c) allowing sufficient time for blood glucose from interstitial fluid in equilibrium with capillaries to reflux epithelial tissue to diffuse and pass through the epithelium into the aqueous medium. Non-invasive test method. 69. The method of claim 68, further comprising the step of examining the glucose soluble medium for the presence of glucose. 69. The method of claim 68, wherein the glucose soluble medium is supported by a hydrogel. 69. The method of claim 68, wherein the permeation enhancer consists of natural bile salts. 69. The method of claim 68, wherein the permeation enhancer consists of a synthetic permeation enhancer. (a) a permeation enhancer capable of enhancing glucose permeability through the mucosa, the method comprising obtaining a certain amount of glucose water-soluble medium supported by a support material; (b) temporarily positioning a glucose soluble medium relative to the mucosa; (c) allowing sufficient time for blood glucose from interstitial fluid to be balanced with capillaries refluxing mucosal tissue to diffuse and pass through the mucosa to the aqueous medium; And (d) testing the glucose soluble medium for the presence of glucose. 74. The method of claim 73, wherein the glucose water soluble medium is supported by hydrogel. (a) obtaining a certain amount of glucose soluble medium comprising a penetration enhancer capable of enhancing the permeability of glucose through the skin, supported by a support material, and having a substantially negligible glucose concentration; (b) temporarily positioning a glucose soluble medium with respect to the skin; (c) allowing sufficient time for the blood glucose from the interstitial fluid to equilibrate with the capillaries refluxing the skin to diffuse and pass through the mucosa into the aqueous medium; And (d) testing the glucose soluble medium for the presence or absence of glucose. 76. The method of claim 75, wherein the permeation enhancer consists of DMSO. 76. The method of claim 75, wherein the permeation enhancer consists of ethanol. ※ Note: It is to be disclosed by the contents of the original application.