KR920017668A - 암 전이 억제 또는 예방 방법 및 이를 위한 제제 - Google Patents

암 전이 억제 또는 예방 방법 및 이를 위한 제제 Download PDF

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Publication number
KR920017668A
KR920017668A KR1019920003685A KR920003685A KR920017668A KR 920017668 A KR920017668 A KR 920017668A KR 1019920003685 A KR1019920003685 A KR 1019920003685A KR 920003685 A KR920003685 A KR 920003685A KR 920017668 A KR920017668 A KR 920017668A
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KR
South Korea
Prior art keywords
inhibiting
mammal
hirudin
methods
cancer metastasis
Prior art date
Application number
KR1019920003685A
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English (en)
Inventor
브라이언 월리스 로버트
제이. 피들러 아이제이어
노리코 에수미
Original Assignee
시바-가이기 에이지
더 보드 오브 리전츠 유니버서티 오브 텍사스 시스템
유시피 겐-파마 에이지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 시바-가이기 에이지, 더 보드 오브 리전츠 유니버서티 오브 텍사스 시스템, 유시피 겐-파마 에이지 filed Critical 시바-가이기 에이지
Publication of KR920017668A publication Critical patent/KR920017668A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

암 전이 억제 또는 예방 방법 및 이를 위한 제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 종양 전이의 억제 또는 예방용 약제학적 조성물을 제조하기 위한 히루딘의 용도.
  2. 제1항에 있어서, 히루딘이 데설파토히루딘 변이체 또는 이의 돌연변이체의 용도.
  3. 제1항 또는 2항에 있어서, 히루딘이 데설파토히루딘 HV1인 용도.
  4. 제1항 내지 3항중 어느 한 항에 있어서, 약제학적 조성물이 비경구 투여를 위한 용도.
  5. 제1항 내지 4항중 어느 한 항에 있어서, 약제학적 조성물이 포유동물에 투여하기 위한 용도.
  6. 제5항에 있어서, 포유 동물이 사람인 용도.
  7. 포유 동물에 유효량의 히루딘을 투여함을 특징으로하여, 포유 동물에서 종앙 전이를 억제하거나 예방하는 방법.
  8. 포유 동물에서 종양 전이를 억제하거나 예방하기 위한 히루딘을 함유하는 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920003685A 1991-03-08 1992-03-06 암 전이 억제 또는 예방 방법 및 이를 위한 제제 KR920017668A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66654091A 1991-03-08 1991-03-08
US07/666,540 1991-03-08

Publications (1)

Publication Number Publication Date
KR920017668A true KR920017668A (ko) 1992-10-21

Family

ID=24674487

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920003685A KR920017668A (ko) 1991-03-08 1992-03-06 암 전이 억제 또는 예방 방법 및 이를 위한 제제

Country Status (9)

Country Link
EP (1) EP0503829A3 (ko)
JP (1) JPH04327539A (ko)
KR (1) KR920017668A (ko)
AU (1) AU659432B2 (ko)
CA (1) CA2062388A1 (ko)
IE (1) IE920732A1 (ko)
IL (1) IL101173A0 (ko)
NZ (1) NZ241880A (ko)
ZA (1) ZA921689B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9401448D0 (en) * 1994-01-26 1994-03-23 Ciba Geigy Ag Stable dry powders
GB9401447D0 (en) 1994-01-26 1994-03-23 Ciba Geigy Ag Pharmaceutical compositions
US6274553B1 (en) 1997-01-20 2001-08-14 Japan Energy Corporation Method for stabilizing peptides and freeze-dried medicinal compositions containing peptides obtained by using the method
DE10162521A1 (de) * 2001-12-19 2003-07-17 Goetz Nowak Verwendung von molekulargewichtserweiterten Substanzen in der Tumortherapie
WO2004026252A2 (en) * 2002-09-23 2004-04-01 The Regents Of The University Of Michigan Glioma treatments
US7795205B2 (en) * 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
US8357652B2 (en) 2009-11-20 2013-01-22 Academia Sinica Anti-tumor fibrillar human serum albumin methods and compositions
US8501241B1 (en) 2012-09-17 2013-08-06 Biopep Solutions, Inc. Treating cancer with a whole, leech saliva extract
CN116850272A (zh) * 2022-03-28 2023-10-10 珠海天健和睦生物制药有限公司 重组水蛭素在制备用于治疗肝癌的药物中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588587A (en) * 1983-03-01 1986-05-13 Pennsylvania Hospital Method of treatment to inhibit metastasis
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
IL86857A (en) * 1988-06-24 1994-04-12 Yissum Res Dev Co Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same
US5179196A (en) * 1989-05-04 1993-01-12 Sri International Purification of proteins employing ctap-iii fusions
CA2064195A1 (en) * 1989-07-20 1991-01-21 John M. Maraganore Hirudin peptide derivatives
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
DE3939801A1 (de) * 1989-12-01 1991-06-06 Basf Ag Neue proteine und ihre herstellung
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin
GB2247239A (en) * 1990-08-22 1992-02-26 Ciba Geigy Ag Hirudin conjugates with polyoxyethylene

Also Published As

Publication number Publication date
AU659432B2 (en) 1995-05-18
IL101173A0 (en) 1992-11-15
AU1109292A (en) 1992-09-10
JPH04327539A (ja) 1992-11-17
IE920732A1 (en) 1992-09-09
EP0503829A3 (en) 1993-06-02
NZ241880A (en) 1997-04-24
CA2062388A1 (en) 1992-09-09
ZA921689B (en) 1992-10-28
EP0503829A2 (en) 1992-09-16

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