KR920002565A - Heterocyclic halide manufacturing method - Google Patents

Heterocyclic halide manufacturing method Download PDF

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Publication number
KR920002565A
KR920002565A KR1019900011009A KR900011009A KR920002565A KR 920002565 A KR920002565 A KR 920002565A KR 1019900011009 A KR1019900011009 A KR 1019900011009A KR 900011009 A KR900011009 A KR 900011009A KR 920002565 A KR920002565 A KR 920002565A
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KR
South Korea
Prior art keywords
iii
heterocyclic
thibutylthionite
general formulas
heterocyclic halide
Prior art date
Application number
KR1019900011009A
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Korean (ko)
Other versions
KR920008616B1 (en
Inventor
김용해
이춘호
Original Assignee
이상수
한국과학기술원
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Priority to KR1019900011009A priority Critical patent/KR920008616B1/en
Publication of KR920002565A publication Critical patent/KR920002565A/en
Application granted granted Critical
Publication of KR920008616B1 publication Critical patent/KR920008616B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/58—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음.No content.

Description

헤테로고리 할라이드 제조방법Heterocyclic halide manufacturing method

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (3)

일반식(I'), (II'), (III')의 헤테고리 일차 아민에 염화구리(또는 브롬화구리)와 티부틸티오나이트라이트(또는 티부틸티오나이트레이트)를 사용하여 유기용매에서 탈아미노-치환 반응을 특징으로 하는 일반식(I'), (II'), (III')의 헤테로고리 할라이드의 제조방법.Copper chloride (or copper bromide) and thibutylthionite (or thibutylthionite) were used in the heterocyclic primary amines of general formulas (I '), (II'), and (III ') to remove them from the organic solvent. A process for the preparation of heterocyclic halides of formula (I '), (II'), (III ') characterized by amino-substitution reactions. 위의 일반식(I'), (II'), 및 (III')에 있어서 X는 염소나 브롬을 나타내고, 일반식 (III) 및 (III')에 있어서 R은 벤질기나 리보스기를 표시한다.In the general formulas (I '), (II'), and (III '), X represents chlorine or bromine, and in general formulas (III) and (III'), R represents a benzyl group or a ribose group. 제1항에 있어서, 염화구리(혹은 브롬화구리)와 티부틸티오나라이트(혹은 티부틸티오나이트레이트)의 첨가량이 일반식(I'), (II'), (III')의 헤테로고리 일차 아민에 대해서 1 : 2 : 2의 몰비를 가지는 것을 특징으로 하는 일반식(I'), (II'), (III')의 헤테로고리 할라이드의 제조방법.2. The heterocyclic primary according to claim 1, wherein the addition amount of copper chloride (or copper bromide) and thibutylthionite (or thibutylthionite) are added in the general formulas (I '), (II') and (III '). A method for producing a heterocyclic halide of general formula (I '), (II') and (III '), which has a molar ratio of 1: 2: 2 relative to amine. 제1항에 있어서, 반응조건이 중성이고 온화하며 유기용매에서 이루어지는 것을 특징으로 하는 헤테로고리 할라이드의 제조방법.The method for preparing a heterocyclic halide according to claim 1, wherein the reaction conditions are neutral, mild and made of an organic solvent. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019900011009A 1990-07-19 1990-07-19 Process for preparing heterocyclic holide compound KR920008616B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019900011009A KR920008616B1 (en) 1990-07-19 1990-07-19 Process for preparing heterocyclic holide compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019900011009A KR920008616B1 (en) 1990-07-19 1990-07-19 Process for preparing heterocyclic holide compound

Publications (2)

Publication Number Publication Date
KR920002565A true KR920002565A (en) 1992-02-28
KR920008616B1 KR920008616B1 (en) 1992-10-02

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ID=19301450

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900011009A KR920008616B1 (en) 1990-07-19 1990-07-19 Process for preparing heterocyclic holide compound

Country Status (1)

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KR (1) KR920008616B1 (en)

Also Published As

Publication number Publication date
KR920008616B1 (en) 1992-10-02

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