KR920002137A - Percutaneous Absorption Steroid Hormones - Google Patents

Abstract

No content

Description

Percutaneous Absorption Steroid Hormones

As this is a public information case, the full text was not included.

1 is a perspective view of a life-size of a preferred example of the present invention

2 2 is a cross-sectional view taken along the line 2-2 of FIG.

Fig. 3 Graph showing the results of the study of carcass skin penetration rate of the human body

Claims (13)

Percutaneous absorption steroid hormone delivery system consisting of an impermeable support and a polymer adhesive matrix attached to the impermeable support, having the following composition, 0.1-10% active ingredient by weight, about 4-30% excipient, skin penetration A porous membrane consisting of about 0.1-20% of an accelerator, about 2-20% of a skin irritant or preventive agent, and about 50-92% of a carrier (adhesive polymer) of an active ingredient, or an uncontrolled proportion between the polymer layers Have The transdermal absorption steroid hormone delivery system of claim 1, wherein the active ingredient is a female hormone selected from the group consisting of estrogens, estrogen derivatives, or mixtures thereof. The transdermal absorption steroid hormone delivery system according to claim 1 or 2, wherein the active ingredient is 17-β-estradiol. The transdermal absorption steroid hormone delivery system of claim 1 wherein the adhesive polymer is an acrylic multipolymer. The transdermal absorption steroid hormone delivery system of claim 1, wherein the adhesive polymer is a mixed polymer of an acrylic polymer and a silicone polymer. The transdermal absorption steroid hormone delivery system of claim 1, wherein the adhesive polymer is a mixed polymer of a synthetic rubber polymer and a polyurethane polymer. The transdermal absorption steroid hormone delivery system of claim 1, wherein the excipient is selected from the group consisting of polyethylene glycol, polyethylene glycol derivatives, and mixtures thereof. The transdermal absorption steroid hormone delivery system of claim 1, wherein the excipient is selected from the group consisting of propylene glycol, propylene glycol derivatives, and mixtures thereof. The transdermal absorption steroid hormone delivery system of claim 1, wherein the skin resistance reducing agent is lauryl diethanolamine or its derivative. The transdermal absorption steroid hormone delivery system of claim 1, wherein the skin resistance reducing agent is sodium lauryl sulfate and derivatives thereof. The transdermal absorption steroid hormone delivery system of claim 1, wherein the skin irritation reducing or preventing agent is sucrose cocoate or sucrose derivatives and mixtures thereof. The transdermal absorption steroid hormone delivery system of claim 1, further comprising a release liner, wherein a matrix is sandwiched between the support and the release liner before use. Percutaneous absorption female steroid hormone delivery system comprising an impermeable support and a polymer adhesive matrix attached to the impermeable support, having the following composition, 0.1-10% by weight of active ingredient, about 4-30% of excipient, skin A porous membrane consisting of about 0.1-20% of penetration promoter, about 2-20% of skin irritant or inhibitor and about 50-92% of carrier (adhesive polymer) of active ingredient Have ※ Note: The disclosure is based on the initial application.