KR920000863B1 - Biocidal compositions - Google Patents

Abstract

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Description

Bactericidal composition

The present invention relates to fungicides, in particular to a virus eradication material composition.

Substances such as hypochlorite in the form of liquid sodium chlorate (household bleach) or calcium hypochlorite (bleach) and cyanuric acid tetrachloride and chloroamine T as household, industrial, and small amounts of agricultural surface and sanitary agents for many years. Has been used.

These products are commercially available as powders and liquids, mainly as liquids, and have a pH in the range of 7-11. These are all defective. Liquid products are corrosive, unstable and easily deactivated by organic materials, limiting their usefulness and reliability, especially in farm conditions that use large amounts of organic materials. Powder products are more stable but have very low reactivity. Chloroamine T, for example, requires extremely high concentrations in order to have a bactericidal effect that can be used, and its activity is severely affected by organic substances.

Because these products are available in alkaline or neutral form, their antiviral activity is extremely limited, and in view of human health and animal health today, the primary purpose of any disinfectant is primarily secondary against humans and livestock. It must be an inert virus particle that causes a bacterial infection.

Ideal formulations for this purpose should be acidic and in use should be diluted to produce a solution most preferably at a pH of approximately 2-3. However, a simple hypochlorite solution at pH 2.3 releases chlorine gas from the hypochlorite source, so it has not been possible to obtain such a good virus eradication.

There is a wide range of prior art dealing with formulations proposed to obtain a stable acidic system, among which DuPont's British Patent No. 932750. However, the formulations prepared according to this DuPont patent are very unstable in powder form and generate chlorine gas in a short period of time in production. This is mainly due to the use of high concentrations of sulfamic acid and inorganic acid salts added to obtain the acidity of the disturbances. The use of mineral acid enhancers present in sulfamic acid as chlorine receptors and stabilizers, in addition to imparting instability into the formulation, also makes the formulation highly corrosive. Another disclosure is British Patent No. 2,078,522 wherein Dupont is obtained by using sulfamic acid as a chlorine receptor to a minimum level and phosphate mixed with malic acid or succinic acid or sulfic acid as a non-reducing agent to obtain the required acidity in use. Attempts to overcome the deficiencies found in its patents. This produces a relatively stable powder system that does not generate chlorine gas when stored for a long time at 37 ° C, and does not generate chlorine to the extent that the smell can be visually inspected when the product is dissolved in water at an appropriate dilution. However, if the product is stored in humid conditions or the instructions are not followed and a concentrated solution is made, chlorine is generated.

It is an object of the present invention to improve the known fungicide composition by providing a composition which reacts through the generation of chlorine / tooth chlorine industry and can inhibit the generation of chlorine not only in the appropriate diluent but also in the presence of a small amount of water. These conditions are easily formed when used on a farm, ie when water is sprayed into the composition or when the concentrated solution is made without following the tips to make the composition.

The present invention provides a dry, water-soluble bactericide composition consisting of: a) 0.01 to 5 parts by weight of water-soluble inorganic halogen compound, b) 25 to 60 parts by weight of oxidizing agent which reacts with halogen compound in aqueous solution to generate hypohalogenate ions, c) 3 to 8 parts by weight of sulfamic acid, d) 0 to 0 20 weight percent non-reducing organic acid, e) 10 to 30 weight percent anhydrous alkali metal phosphate. The pH of the 1 wt% aqueous solution of this composition is 1.2 to 5.5. Preferred inorganic halides are sodium chloride and are in a 0.2 to 2 weight ratio when the composition is dissolved in normal drinking water.

As such, the problem of chlorine emission is avoided by using sodium chloride in low concentration, and at the same time, it increases the bactericidal activity of the aqueous solution of the composition. This is due to the buffer effect and the chelate effect of the alkali metal phosphate.

The oxidizing agent is preferably persulfate or peroxyphthalate, especially in the latter case momoperoxyphthal potassium. However, preferred oxidizing agents are commercially available persulfate triple potassium salts expressed as 2KHSO ₅ , KHSO ₄ , K ₂ SO _{4 in} a ratio of 45:25:30.

Other oxidants can also be used in the same amount as the oxidizer powder. This type of oxidant powder conveniently measures the filtered oxo produced by reacting with potassium iodide. This process is standard in the art and the results can be expressed as available hypohalogenates, halogens or oxygen or simply “oxidizing powders”.

The non-reducing organic acid is an organic acid which does not reduce the oxidation powder of 1% aqueous solution of the test mixture which is left for 30 minutes with the addition of the test solution of 20 parts by weight of sulfamic acid of 45 parts by weight of sodium chloride 5 parts by weight of tribasic potassium salt of 50 parts by weight as described above. It is defined as Preferred organic acids are malic acid, which is succinic acid.

Although the preferred inorganic halide is sodium chloride, for example chloride, brominated or potassium iodide or other halides such as brominated or sodium iodide may be used, provided they do not react with phosphates to form insoluble salts.

The alkali metal phosphate may be sodium hexametaphosphate, known as sodium polyphosphate. Other phosphates which can be used in place of all or part of the sodium hexametaphosphate include tetrasodium pyrophosphate, yl phosphate, also trisodium and also the corresponding potassium compounds.

Phosphates act as buffers and chelates with sulfamic acid in a flat pH curve so that the composition is effective over a wide range of conditions, such that it can be dissolved in hard water and even in seawater without adversely affecting its bactericidal properties. do.

Any surfactant that can be used for acids or oxidants can be used. Particularly effective surfactants are sodium dodecylbenzene sodium sulfonate. Other suitable surfactants include lauryl ether sulfate, ethylene oxide / propylene oxide alkylphenol condensates, polyglycol ethers of fatty alcohols, fatty acid ethylene oxide condensates, polyglycol ethers of alkylphenols and fatty alcohol ethoxylates. Incorporation of one surfactant into this composition presents a significant advantage, particularly high levels of surfactants, which enable cleaning and disinfection in a single operation. This is of great importance when washing domestic farms that raise farm animals.

The composition is preferably sold in the form of a powder, and when used, it is preferably used in water at the required concentration immediately before use, although the service life of the aqueous solution product is significantly longer than comparable disinfectants currently on the market. If dissolved in, it tends to lose its effectiveness even after a few hours. The presence of phosphate in the composition contributes to prolong the service life of the aqueous solution. Phosphates enhance the efficacy of the composition when dissolved in hard water. Phosphates cause the sequestration of certain metal ions that may cause rapid decomposition of the oxidant present in the solution.

Aqueous products are a broad spectrum disinfectant and are believed to expose the RNA or DNA nucleus of the virus by first destroying the virus's lipoprotein cell membrane or the outer layer's lipoprotective layer, although the method of degradation of the virus is unknown. Sulfamic acid acts as a chlorine receptor to trap the chlorine that is initially generated as an addition product with sulfamic acid in solution, thereby avoiding the release of chlorine gas. Keeping chlorides and other halide concentrations low helps prevent the release of chlorine without doing anything to reduce the bactericidal efficacy of the composition.

Embodiment of the present invention

One fungicide composition was prepared by mixing the following ingredients together:

Sodium Chloride 1.5 Ratio

Persulfate Triple Potassium Salt 550.0 Ratio

Sulfamic Acid 5.0 Ratio

Malic acid 10.0 ratio

Sodium hexametaphosphate 18.5 ratio

Dodecylbenzene Sodium 15.0 Ratio

Triple potassium potassium persulfate is represented by the general formula of 2KHSO ₅ , KHSO ₄ , K ₂ SO ₄ and is marketed under the trademark “Caroat”. It has a minimum active coral content of 4.5%. Sodium hexametaphosphate is also known as sodium polyphosphate and is used in the form of powders or particles.

The composition is prepared by first mixing phosphate and sulfonate together, then adding persulfate and acid and finally adding sodium chloride. Prepared by adding 1% by weight of this composition to de-ionized water.

Tests The bactericidal activity of the composition was carried out in accordance with the standard test method of Waybridge, Surrey's agricultural, fishery, and food quality (MAFF) and the standard test method of the Animal Virus-Laboratory of Pirbright, Woking, Surrey. This test showed the efficacy of this composition against the broad spectrum below for virus and myrus infections at dilutions showing a 410 g reduction in virus titration.

As such, an important benefit of this disinfectant composition is the very broad spectrum of bactericidal actives. It is also possible to greatly dilute the composition of the present invention as compared to the previous disinfecting compositions effective with respect to the selected viral infection, and thus be more cost effective.

For example, the results compared between the compositions of the present invention and those presented in Example 3 of British Patent No. 2,078,522A show that the foot and mouth viruses (F & M), porcine cystic disease viruses (SDV), and poultry plastviruses. The following levels of approval of the Department of Agriculture, Fisheries and Food Products (MAFF) regarding the General Level (GO) of the MAFF test for (FP) and Bon cholera are given.

The test was conducted to evaluate the short and long term stability of the dry mixed composition. In the first test, samples were stored at 37 ° C. in sealed containers and periodically taken as shown below:

Changes in% of soluble chlorine were heard within the predicted test area and showed good short term stability.

Another sample was made and the two batches were stored at 20 ° C. and 37 ° C., respectively. Results for% soluble chlorine were obtained as follows:

Short-term exposure in vitro was performed under simulated farm conditions for the following bacteria, and the results of bacteriological counts after a specific exposure time were:

The figures indicated represent the number of organisms that survived after a certain exposure period.

The test was also carried out using the above material as a dilution of 1: 400 to remove the fungal species taken from the chicken hatchery material. This material was found to be similar overall for the fungal species tested, namely A. flarus, penicillin sp and Scopul-Ariopsis sp.

It was also carried out including the addition of a 0.5% by weight solution of this composition to the poultry drink. One week after the start of the test, the birds were weighed and compared with the reference group who drank water without any additives.

In addition, the test was carried out by using a 0.5% by weight solution for the chicks a day and comparing the chicks of the test group with the reference group.

The test was also carried out on the effect of spraying the composition at 0.5% by weight on livestock cages, which included livestock, sows, and newborn pigs, calves and horses. Clinical examination of the skin and mucous membranes of livestock was carried out before and after daily spraying for a long time, indicating that there was no inflammation in the part of the animal and no other reactions. At the same time, significant benefits were gained in terms of growth and overall plant conversion efficiency.

Another test was conducted comparing the effects of using different phosphates. In each example, a composition comprising 18.5 wt% phosphate was prepared, and a 1 wt% aqueous solution of the composition was prepared. In test A, the composition was dissolved in de-ionized water, in test B the composition was dissolved in tap water, and in test C, the composition was dissolved in seawater.

The solution made with de-ionized water did not smell chlorine, the solution made with tap water monosodium phosphate had a slight odor and the seawater used gave a slight or very slight odor from each phosphate.

It was also carried out to investigate the effect of adding malic acid and sulfamic acid to an aqueous solution of a composition prepared using sodium hexametaphosphate as described above as an example.

In each case 10% by weight acid solution was prepared and added to a solution of 1% by weight composition. The addition of sulfamic acid eventually reached pH 1.2 and there was no detectable chlorine odor even at this pH. Malic acid reached a pH of 1.8 and no chlorine odor was detected.

A test was also conducted to evaluate the effect of succinic acid instead of malic acid. The solution was prepared by mixing together as a dry powder component in the manner described above and then one part mixture was dissolved in 100 parts water. Both the malic and succinic solutions worked in exactly the same way. The only difference detected was that the pH of malic acid was 2.6 while the pH of succinic acid was 2.5.

The dry powder mixture was prepared by mixing the following:

Potassium persulfate 50 weight ratio

Sulfamic acid 5 weight ratio

Malic acid 10 weight ratio

Dodecylbenzene sodium sulfonate 15 weight ratio

20 weight ratios of sodium chloride and sodium hexametaphosphate

In order to measure the effect of sodium chloride on chlorine emissions, samples were prepared using different ratios of sodium chloride and sodium hexametaphosphate. A dough containing 20 gm of this mixture and 5 ml of water was prepared and a 20 wt% aqueous solution of the mixture was prepared. The result is:

Even the very serious tests that supplemented the solid product with a simulated wetting dough showed the lowest chlorination of a mixture containing 2.5 weight sodium chloride, indicating complete safety.

Significant bactericidal activity of this composition according to the present invention has been obtained as a unique composition for use with bacterial and fungal tactility.

The use of organic acids, such as malic acid, to achieve low pH, provides the following benefits: a) non-corrosive, b) fabric is not bleached, c) this aqueous solution can be consumed by chicks d) Aqueous products do not cause skin or eye irritation, e) No chlorine generation under specific conditions of use, f) Bathing in aqueous solutions is possible, g) Aqueous solutions can be sprayed into the room without discomfort. , h) no staining and no coloring.

In use, the operation of the composition is complex. The amino acid in the outer protective layer of the sealed virus is reacted as a fourth activator under acidic conditions and co-precipitates with dodecylbenzenesulfonate or the next anionic surfactant. Lipids in the outer envelope are also dissolved by the surfactant. Also, for example, various organic components of viruses such as amino acids, polypentides, and nuclear DNA or RNA are oxidized at low pH by the initial oxygen generated at low pH conditions or by hypochlorous acid.

Claims (7)

a) 0.01 to 5 weight ratio of water-soluble inorganic halogen compound, b) 25 to 60 weight ratio of oxidizing agent which reacts with halide in aqueous solution to generate hypohalogenate ions, c) 3 to 8 weight ratio of sulfamic acid, d A) dry water-soluble, characterized in that it comprises a non-reducing organic acid in an amount of 0 to 20% by weight and also an anhydrous alkali metal phosphate in an amount of 10 to 30% by weight, while the pH of the 1% by weight aqueous solution of the composition ranges from 1.2 to 5.5. Biocidal composition. The composition of claim 1 wherein the inorganic halide is sodium chloride and comprises 0.2 to 2 weight percent. The composition of claim 1 wherein the non-reducing organic organic acid is selected from malic acid and succinic acid and comprises it in a 7 weight ratio. 2. The composition of claim 1 wherein the alkali metal phosphate is sodium hexametaphosphate. The composition according to claim 1, wherein the alkali metal phosphate is selected from tetrasodium pyrophosphate, yl phosphate, di, trisodium and a corresponding potassium compound. 2. A composition according to claim 1, wherein the composition comprises 20 weight percent anhydrous surfactant and is first prepared by mixing an alkali metal phosphate with a surfactant. a) 1.5 weight percent sodium chloride, b) 50 weight percent triple potassium persulfate salt, c) 5 weight percent sulfamic acid, d) 10 weight ratio malic acid or succinic acid, e) 18.5 weight ratio sodium polyphosphate, and and f) a dry aqueous sterilizing composition consisting of 15 weight percent sodium dodecylbenzenesulfonate.