KR910016314A - Topical Permanent Dosing Composition of Antibiotics - Google Patents

Topical Permanent Dosing Composition of Antibiotics Download PDF

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Publication number
KR910016314A
KR910016314A KR1019900004398A KR900004398A KR910016314A KR 910016314 A KR910016314 A KR 910016314A KR 1019900004398 A KR1019900004398 A KR 1019900004398A KR 900004398 A KR900004398 A KR 900004398A KR 910016314 A KR910016314 A KR 910016314A
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KR
South Korea
Prior art keywords
topical
composition
polycaprolactone
active ingredient
ingredient
Prior art date
Application number
KR1019900004398A
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Korean (ko)
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KR920005648B1 (en
Inventor
정종평
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정종평
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 정종평 filed Critical 정종평
Priority to KR1019900004398A priority Critical patent/KR920005648B1/en
Priority to CN91102855A priority patent/CN1059277A/en
Priority to JP3094754A priority patent/JPH0751518B2/en
Publication of KR910016314A publication Critical patent/KR910016314A/en
Application granted granted Critical
Publication of KR920005648B1 publication Critical patent/KR920005648B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Abstract

내용 없음No content

Description

항생활성 성분의 치과용 국소지속성 투여조성물Topical Permanent Dosing Composition of Antibiotics

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 본 발명에 따른 조성물로부터 제조된 고분자 기질(실시예4)에 있어서, 최초 24시간 동안 고분자 기질로부터 미노싸이클린의 방출비를 나타낸 그래프(a)와, 시간경과에 따른 미노싸이클린의 분획 방출비를 나타낸 그래프(b)이고, 제2도는 본 발명에 따른 실시예5에서 측정된 최초 24시간 경과시의 PCL필름에서의 미노싸이클린 방출비를 나타낸 그래프(a)와, 7일간의 20%미노싸이클린 함유 PCL필름에 대한 방출비를 나타낸 그래프(b)이며, 제3도는 본 발명의 조성물로 제조된 EVA 고분자 기질(실시예8)에 대한 테트라싸이클린의 방출비를 나타낸 그래프이다.1 is a graph (a) showing the release ratio of minocycline from the polymer substrate for the first 24 hours in the polymer substrate prepared from the composition according to the present invention (Example 4), and fractional release of minocycline over time. FIG. 2 is a graph showing the ratio, and FIG. 2 is a graph showing the minocycline release ratio in the PCL film after the first 24 hours measured in Example 5 according to the present invention, and 20% mino for 7 days. (B) is a graph showing the release ratio for the cyclin-containing PCL film, Figure 3 is a graph showing the release ratio of tetracycline to the EVA polymer substrate (Example 8) prepared with the composition of the present invention.

Claims (5)

유효성분으로 하는 항생활성 성분을 유효 성분으로 하는 치과용 투여 조성물에 있어서 상기 유효성분과 고분자 성분으로의 폴리(에틸렌 비닐 아세테이트), 폴리 카프로락톤 및 폴리 카프로락톤과 폴리에틸렌 글리콜의 혼합물 중에서 선택된 어느 하나를 함유하고 있되, 상기 고분자 성분에 대해 상기 유효 성분이 20~30중량%로 함유되어 있는 것을 특징으로 하는 항생활성 성분의 치과용 국소 지속성 투여 조성물.Dental administration composition comprising an anti-bioactive ingredient as an active ingredient as an active ingredient contains any one selected from poly (ethylene vinyl acetate), polycaprolactone and polycaprolactone and polyethylene glycol as the active ingredient and a polymer ingredient Wherein, the active topical topical administration composition of the antimicrobial component, characterized in that containing 20 to 30% by weight based on the polymer component. 제1항에 있어서, 상기 폴리(에틸렌 비닐 아세테이트)는 비닐 아세테이트 함량이 10~40%로 함유되어 있는 것을 특징으로 하는 국소 지속성 투여 조성물.The topical sustained-dose composition according to claim 1, wherein the poly (ethylene vinyl acetate) has a vinyl acetate content of 10-40%. 제1항에 있어서, 상기 폴리카프로락톤과 폴리에틸렌 글리콜은 5~7 : 5~3의 중량비로 혼합된 것을 특징으로 하는 국소 지속성 투여 조성물.The method of claim 1, wherein the polycaprolactone and polyethylene glycol are mixed in a weight ratio of 5-7: 5-3. 제1항 또는 제3항에 있어서, 상기 폴리카프로락톤과 분자량이 50,000~100,000이고, 폴리에틸렌글리콜은 분자량이 2,000~30,000인 것을 특징으로 하는 국소 지속성 투여 조성물.The topical long-acting composition according to claim 1 or 3, wherein the polycaprolactone has a molecular weight of 50,000 to 100,000 and polyethylene glycol has a molecular weight of 2,000 to 30,000. 항생활성 성분을 유효성분으로 하는 치과용 투여 조성물에 있어서, 상기 유효 성분과 고분자 성분으로서 폴리(에틸렌 비닐 아세테이트), 폴리 카프로락톤 및 폴리카프로락톤과 폴리 에틸렌글리콜의 혼합물 중에서 선택된 어느 하나를 함유하고 있되, 상기 고분자 성분에 대해 상기 유효성분이 20~30중량%로 함유되어 있는 조성물을 100~400um두께의 필름 또는 첨봉(Cone)형으로 주조하여서된 항생활 성분의 치과용 국소 지속성 투여 조성물 매트릭스.A dental administration composition comprising an antimicrobial ingredient as an active ingredient, wherein the active ingredient and the polymer ingredient contain any one selected from poly (ethylene vinyl acetate), polycaprolactone, and a mixture of polycaprolactone and polyethylene glycol. And a matrix comprising a composition of 20-30% by weight of the active ingredient with respect to the polymer component, wherein the composition is cast into a 100-400 um thick film or a stick form to form a topical topical dosage composition for dental use. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019900004398A 1990-03-31 1990-03-31 Dental applicable released composition containing antibiotics KR920005648B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1019900004398A KR920005648B1 (en) 1990-03-31 1990-03-31 Dental applicable released composition containing antibiotics
CN91102855A CN1059277A (en) 1990-03-31 1991-03-30 Local drug delivery compositions in the dental applications
JP3094754A JPH0751518B2 (en) 1990-03-31 1991-04-01 Topically sustained dental composition containing antibiotics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019900004398A KR920005648B1 (en) 1990-03-31 1990-03-31 Dental applicable released composition containing antibiotics

Publications (2)

Publication Number Publication Date
KR910016314A true KR910016314A (en) 1991-11-05
KR920005648B1 KR920005648B1 (en) 1992-07-11

Family

ID=19297549

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900004398A KR920005648B1 (en) 1990-03-31 1990-03-31 Dental applicable released composition containing antibiotics

Country Status (3)

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JP (1) JPH0751518B2 (en)
KR (1) KR920005648B1 (en)
CN (1) CN1059277A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614578A (en) * 1994-10-28 1997-03-25 Alza Corporation Injection-molded dosage form
JP4202656B2 (en) * 2002-02-19 2008-12-24 サンスター株式会社 Topical sustained-release ointment
KR102007069B1 (en) * 2016-09-26 2019-08-05 경북대학교 산학협력단 Manufacturing method for polyvinylalcohol film containing antibiotics, mixed with inorganic particles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4764377A (en) * 1983-10-07 1988-08-16 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases

Also Published As

Publication number Publication date
KR920005648B1 (en) 1992-07-11
CN1059277A (en) 1992-03-11
JPH0751518B2 (en) 1995-06-05
JPH04321630A (en) 1992-11-11

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