KR910011892A - Method for producing dipeptide derivatives - Google Patents

Method for producing dipeptide derivatives Download PDF

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Publication number
KR910011892A
KR910011892A KR1019890019970A KR890019970A KR910011892A KR 910011892 A KR910011892 A KR 910011892A KR 1019890019970 A KR1019890019970 A KR 1019890019970A KR 890019970 A KR890019970 A KR 890019970A KR 910011892 A KR910011892 A KR 910011892A
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KR
South Korea
Prior art keywords
general formula
following general
atom
represented
derivative represented
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Application number
KR1019890019970A
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Korean (ko)
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KR920000694B1 (en
Inventor
박병욱
정훈
이석관
이기승
Original Assignee
이승동
주식회사 선경인더스트리
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Priority to KR1019890019970A priority Critical patent/KR920000694B1/en
Publication of KR910011892A publication Critical patent/KR910011892A/en
Application granted granted Critical
Publication of KR920000694B1 publication Critical patent/KR920000694B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

내용 없음No content

Description

디펩타이드유도체의 제조방법Method for producing dipeptide derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (3)

고혈압치료제로 유용한 다음 일반식(Ⅰ)로 표시되는 디펩타이드유도체를 제조함에 있어서, 다음 일반식(Ⅱ)로 표시되는 아미노산유도체와 다음 일반식(Ⅲ)으로 표시되는 페놀유도체를 축합반응시켜서 중간체인 다음 일반식(Ⅳ)로 표시되는 아릴에스터화합물을 제조하고 나서, 이 일반식(Ⅳ)의 화합물과 다음 일반식(Ⅴ)로 표시되는 L-프롤린 나트륨염을 반응시켜서 됨을 특징으로하는 디펩타이드 유도체의 제조방법.In preparing a dipeptide derivative represented by the following general formula (I) useful as a therapeutic agent for hypertension, an amino acid derivative represented by the following general formula (II) and a phenol derivative represented by the following general formula (III) A dipeptide derivative characterized by preparing an aryl ester compound represented by the following general formula (IV) and then reacting the compound of the general formula (IV) with the L-proline sodium salt represented by the following general formula (V). Manufacturing method. 상기 식들중에서, X는 산소원자 또는 황원자를 나타내며, Y는 수소원자, 할로겐원자, 질산기(NO2-) 또는 시안기(-CN)를 나타낸다.In the above formulas, X represents an oxygen atom or a sulfur atom, and Y represents a hydrogen atom, a halogen atom, a nitric acid group (NO 2 —) or a cyan group (-CN). 제1항에 있어서, 상기 축합반응은 축합제로서 디싸이클로헥실카보디이미드 존재하에 시행하는 것을 특징으로하는 디펩타이드유도체의 제조방법.The method of claim 1, wherein the condensation reaction is carried out in the presence of dicyclohexylcarbodiimide as a condensing agent. 고혈압치료효과를 갖는 다음 일반식(Ⅰ)로 표시되는 디펩타이드유도체를 제조하는데 유용한 다음 일반식(Ⅳ)로 표시되는 아릴에스터화합물. An aryl ester compound represented by the following general formula (IV), which is useful for producing a dipeptide derivative represented by the following general formula (I) having a hypertension treatment effect. 상기 식에서, X는 산소원자 또는 황원자를 나타내며, Y는 수소원자, 할로겐원자, 질산기(NO2-) 또는 시안기(-CN)를 나타낸다.In the above formula, X represents an oxygen atom or a sulfur atom, and Y represents a hydrogen atom, a halogen atom, a nitric acid group (NO 2 −) or a cyan group (—CN). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890019970A 1989-12-28 1989-12-28 Process for producing dipeptides derivatives KR920000694B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019890019970A KR920000694B1 (en) 1989-12-28 1989-12-28 Process for producing dipeptides derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019890019970A KR920000694B1 (en) 1989-12-28 1989-12-28 Process for producing dipeptides derivatives

Publications (2)

Publication Number Publication Date
KR910011892A true KR910011892A (en) 1991-08-07
KR920000694B1 KR920000694B1 (en) 1992-01-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890019970A KR920000694B1 (en) 1989-12-28 1989-12-28 Process for producing dipeptides derivatives

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KR (1) KR920000694B1 (en)

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Publication number Publication date
KR920000694B1 (en) 1992-01-20

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Free format text: OPPOSITION NUMBER: 001992001358; OPPOSITION DATE: 19920320