KR910011851A - Benzene condensation derivatives - Google Patents

Benzene condensation derivatives Download PDF

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KR910011851A
KR910011851A KR1019890017973A KR890017973A KR910011851A KR 910011851 A KR910011851 A KR 910011851A KR 1019890017973 A KR1019890017973 A KR 1019890017973A KR 890017973 A KR890017973 A KR 890017973A KR 910011851 A KR910011851 A KR 910011851A
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South Korea
Prior art keywords
derivative
group
methylene
lower alkyl
ethylene
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KR1019890017973A
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Korean (ko)
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KR0133281B1 (en
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모또끼 도리즈끼
도모지 아오쯔까
미쯔오 소에다
구니요시 오구라
요시아끼 다나까
히사요시 가또
나오끼 나까다
나오요시 미우라
히까리 모리따
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이베 사찌아끼
제리아 신야꾸 고오교 가부시끼 가이샤
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Publication of KR910011851A publication Critical patent/KR910011851A/en
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Publication of KR0133281B1 publication Critical patent/KR0133281B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D227/00—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00
    • C07D227/02—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D227/06—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음No content

Description

벤젠 축합 유도체Benzene condensation derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (7)

1. 다음식 (Ⅰ)로 표시되는 벤젠 축합 유도체1. Benzene condensation derivative represented by the following formula (I) 식중, A는 메틸렌, 에틸렌 또는 프로필렌기를 나타내고, B는 메틸렌 또는 에틸렌기를 나타내고, m은 0∼5의 정수이며, X 및 Y는 동일 또는 상이할 수 있으며, 각가 메틸렌 또는 황원자를 나타내고, R1은 수소, 카르복실, 저급알킬옥시카르보닐, 히드록시메틸 또는 포르밀기를 나타내고, R2는 수소, 할로겐, 저급알킬, 저급알콕시, 니트로 또는 아미노기를 나타내며, R3는 수소 또는 저급알킬기를 나타내고, 점선은 임의로 존재할 수 있다.Wherein A represents a methylene, ethylene or propylene group, B represents a methylene or ethylene group, m is an integer from 0 to 5, X and Y may be the same or different, each represents a methylene or sulfur atom, and R 1 is Hydrogen, carboxyl, lower alkyloxycarbonyl, hydroxymethyl or formyl group, R 2 represents hydrogen, halogen, lower alkyl, lower alkoxy, nitro or amino group, R 3 represents hydrogen or lower alkyl group, dotted line May optionally be present. 제1항에 있어서, 벤젠축합 유도체가 광학적 이성질체 또는 광학적 이성질체의 혼합물인 유도체.The derivative of claim 1 wherein the benzene condensation derivative is an optical isomer or a mixture of optical isomers. 제1항에 있어서, 벤젠축합 유도체가 입체 이성질체 또는 입체이성질체의 혼합물인 유도체.The derivative of claim 1 wherein the benzene condensation derivative is a stereoisomer or a mixture of stereoisomers. 하기식(Ⅱ)로 표시되는 N-치환 환상 아미노산 유도체.N-substituted cyclic amino acid derivative represented by the following formula (II). 상기 식중, A는 메틸렌, 에틸렌 또는 프로필렌기를 나타내고, B는 메틸렌 또는 에틸렌기를 나타내고, m은 0∼5의 정수이고, X는 메틸렌기 또는 황원자를 나타내고, R2는 수소, 할로겐, 저급알킬, 저급알콕시, 니트로 또는 아미노기를 나탠고, R3는 수소 또는 저급알킬기를 나타내며, R4는 수소 또는 저급알킬기를 나타내고, 점선은 임의로 존재할 수 있다.Wherein A represents a methylene, ethylene or propylene group, B represents a methylene or ethylene group, m represents an integer of 0 to 5, X represents a methylene group or a sulfur atom, and R 2 represents hydrogen, halogen, lower alkyl, lower Or alkoxy, nitro or amino group, R 3 represents hydrogen or lower alkyl group, R 4 represents hydrogen or lower alkyl group, and dashed line may optionally be present. 제4항에 있어서, N-치환 환상 아미노산 유도체가 특정 L-배열인 유도체.The derivative of claim 4 wherein the N-substituted cyclic amino acid derivative is a specific L-configuration. 제4항에 있어서, N-치환 환상 아미노산 유도체가 특정 D-배열인 유도체.The derivative of claim 4 wherein the N-substituted cyclic amino acid derivative is a specific D-configuration. 제1항, 제2항, 또는 제3항중의 어느 한 벤젠 축합 유도체를 함유하는 뇌순환질환, 뇌대사질환 및 기억장애의 치료 또는 예방 악재.A treatment or prevention adverse effect of cerebral circulatory diseases, cerebral metabolic diseases and memory disorders containing the benzene condensation derivative according to any one of claims 1, 2, or 3. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890017973A 1988-12-08 1989-12-05 Condensed benzene derivatives KR0133281B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP308878/1988 1988-12-08
JP30887888 1988-12-08
JP1260070A JPH0822847B2 (en) 1988-12-08 1989-10-06 Fused benzene derivative, pharmaceutical containing the same, and intermediate for producing the compound
JP260070/1989 1989-10-06

Publications (2)

Publication Number Publication Date
KR910011851A true KR910011851A (en) 1991-08-07
KR0133281B1 KR0133281B1 (en) 1998-04-17

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KR1019890017973A KR0133281B1 (en) 1988-12-08 1989-12-05 Condensed benzene derivatives

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001352A1 (en) * 1993-06-30 1995-01-12 Zeria Pharmaceutical Co., Ltd. Thiazolidine derivative and medicine containing the same
JPH08319280A (en) * 1995-05-23 1996-12-03 Zeria Pharmaceut Co Ltd Production of thiazolidine derivative
TW200404796A (en) * 2002-08-19 2004-04-01 Ono Pharmaceutical Co Nitrogen-containing compound

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54138551A (en) * 1978-04-14 1979-10-27 Sumitomo Chem Co Ltd Novel asymmetric synthesis of optically active 2-alkanoyl- 1,2,3,4-tetrahydro-2-naphthol compound

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JPH0822847B2 (en) 1996-03-06
KR0133281B1 (en) 1998-04-17
JPH02262557A (en) 1990-10-25

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