KR910007952A - New Anthracycline Glycoside Derivatives - Google Patents

New Anthracycline Glycoside Derivatives Download PDF

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Publication number
KR910007952A
KR910007952A KR1019890015375A KR890015375A KR910007952A KR 910007952 A KR910007952 A KR 910007952A KR 1019890015375 A KR1019890015375 A KR 1019890015375A KR 890015375 A KR890015375 A KR 890015375A KR 910007952 A KR910007952 A KR 910007952A
Authority
KR
South Korea
Prior art keywords
formula
compound
glycoside derivatives
anthracycline glycoside
hydroxy
Prior art date
Application number
KR1019890015375A
Other languages
Korean (ko)
Other versions
KR0157612B1 (en
Inventor
옥광대
박정배
Original Assignee
손정삼
동아제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 손정삼, 동아제약 주식회사 filed Critical 손정삼
Priority to KR1019890015375A priority Critical patent/KR0157612B1/en
Priority to US07/600,708 priority patent/US5220001A/en
Priority to JP2284513A priority patent/JP2806621B2/en
Priority to DK90120373.7T priority patent/DK0424899T3/en
Priority to CA002028465A priority patent/CA2028465C/en
Priority to ES90120373T priority patent/ES2096572T3/en
Priority to AT90120373T priority patent/ATE148128T1/en
Priority to DE69029781T priority patent/DE69029781T2/en
Priority to EP90120373A priority patent/EP0424899B1/en
Priority to CN90109514A priority patent/CN1028997C/en
Publication of KR910007952A publication Critical patent/KR910007952A/en
Priority to GR970400389T priority patent/GR3022702T3/en
Application granted granted Critical
Publication of KR0157612B1 publication Critical patent/KR0157612B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Abstract

내용 없음No content

Description

신규 안트라사이클린 클리코사이드 유도체New Anthracycline Glycoside Derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (2)

다음 구조식(I)의 신규 안트라사이클린 글리코사이드 유도체 및 그 약학적으로 사용가능한 산부가염.Novel anthracycline glycoside derivatives of formula (I) and pharmaceutically usable acid addition salts thereof. 식중 n은 0 또는 1내지 10의 정수를 나타낸다.N represents an integer of 0 or 1-10. 다음 구조식(Ⅱ)의 화합물 또는 3,4-위치의 하이드록시가 포함된 화합물.A compound of formula (II) or a hydroxy at the 3,4-position; 식중 X는 할로겐 원자이다.Wherein X is a halogen atom. 다음 구조식(Ⅲ)의 화합물The compound of formula 식중 n은 0또는 1내지 10의 정수이고, R은 수소원자 또는 아미노 보호기이고, A는 수소 또는 알카리금속이다. 과반응시켜서 다음 구조식(IV)의 화합물 또는 그 3,4-위치의 하이드록시가 보호된 화합물을Wherein n is an integer of 0 or 1 to 10, R is a hydrogen atom or an amino protecting group, and A is hydrogen or an alkali metal. Overreacting to the compound of formula (IV) or a hydroxy protected compound of the 3,4-position 식중, n 및 R은 전술한 바와 같다. 제조하고, 3,4-위치의 하이드록시가 보호되거나 R이 보호기인 경우에는 통상의 방법으로 보호기를 제거하고 산부가염으로 전환시켜서 다음 구조식(I)의 화합물.Wherein n and R are as described above. If the hydroxy at the 3,4-position is protected or R is a protecting group, the compound of formula 식중 n은 전술한 바와 같다. 또는 그 약학적으로 사용가능한 염을 제조하는 방법.N is as described above. Or a method for preparing a pharmaceutically usable salt thereof. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890015375A 1989-10-25 1989-10-25 Novel anthrcycline glycoside derivatives KR0157612B1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
KR1019890015375A KR0157612B1 (en) 1989-10-25 1989-10-25 Novel anthrcycline glycoside derivatives
US07/600,708 US5220001A (en) 1989-10-25 1990-10-22 Anthracycline glycoside derivatives
DK90120373.7T DK0424899T3 (en) 1989-10-25 1990-10-24 New anthracycling glycoside derivatives and processes for their preparation
CA002028465A CA2028465C (en) 1989-10-25 1990-10-24 Novel anthracycline glycoside derivatives and preparing method thereof
JP2284513A JP2806621B2 (en) 1989-10-25 1990-10-24 Novel anthracyclines and production method thereof
ES90120373T ES2096572T3 (en) 1989-10-25 1990-10-24 NEW DERIVATIVES OF ANTHRACICLINE GLUCOSIDES AND PROCEDURE FOR THEIR PREPARATION.
AT90120373T ATE148128T1 (en) 1989-10-25 1990-10-24 ANTHRACYCLINGLYCOSIDE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
DE69029781T DE69029781T2 (en) 1989-10-25 1990-10-24 Anthracycline glycoside derivatives and process for their preparation
EP90120373A EP0424899B1 (en) 1989-10-25 1990-10-24 Novel anthracycline glycoside derivatives and preparing method thereof
CN90109514A CN1028997C (en) 1989-10-25 1990-10-25 Anthracycline pharmaceuticals and process for preparing same
GR970400389T GR3022702T3 (en) 1989-10-25 1997-02-27 Novel anthracycline glycoside derivatives and preparing method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019890015375A KR0157612B1 (en) 1989-10-25 1989-10-25 Novel anthrcycline glycoside derivatives

Publications (2)

Publication Number Publication Date
KR910007952A true KR910007952A (en) 1991-05-30
KR0157612B1 KR0157612B1 (en) 1998-10-15

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ID=19291018

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890015375A KR0157612B1 (en) 1989-10-25 1989-10-25 Novel anthrcycline glycoside derivatives

Country Status (1)

Country Link
KR (1) KR0157612B1 (en)

Also Published As

Publication number Publication date
KR0157612B1 (en) 1998-10-15

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