KR910002851A - Isooxazolidine derivatives and preparation method thereof - Google Patents

Abstract

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Description

Isooxazolidine derivatives and preparation method thereof

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Claims (4)

Isooxazolidine derivatives represented by the following structural formula (I). Here, Fn represents that n functional groups F are substituted in the ring to which it is bonded, n is 1,2,3,4, or 5, F may be the same as or different from each other, and each halogen atom, Nitro group, -R ¹ , -OR ¹ , -SR ¹ or -NR ¹ R ² , wherein R ¹ and R ² may be the same or different from each other, and each is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or a cyclic alkyl group Or a substituted wasteyl group, A and B may be the same as or different from each other, and each is a carbon atom or a nitrogen atom. (A) Reacting an aldehyde derivative of the following formula (II) with a hydroxyamine compound to obtain an oxime derivative of the following formula (III), (B) Halogenated oxime derivative to give a halogenated oxime derivative of the following formula (IV) After the reaction, the oxime halide derivative is reacted with a styrene derivative of the following structural formula (V) to obtain a compound of the following structural formula (IV), and then (c) the compound is reacted with an azide compound. The manufacturing method of the iso oxazolidine derivative represented by (I). Here, Fn represents that n functional groups F are substituted in the ring to which it is bonded, n is 1,2,3,4, or 5, F may be the same as or different from each other, and each halogen atom, Nitro group, -R ¹ , -OR ¹ , -SR ¹ or -NR ¹ R ² , wherein R ¹ and R ² may be the same or different from each other, and each is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or a cyclic alkyl group Or a substituted wasteyl group, A and B may be the same or different from each other, each is a carbon atom or a nitrogen atom, and X is Br, Cl or I. (A) reacting a maldehydride derivative of the following formula (II) with a hydroxyamine compound to obtain an oxime derivative of the following formula (III), and (b) reacting a styrene derivative of the following formula (V) with an azide compound To obtain a tetrazole derivative of the following structural formula (iii), and then (c) halogenate the oxime derivative to obtain a halogenated oxime derivative of the following structural formula (IV), and then react the halogenated oxime derivative with the tetrazole derivative. A method for producing an isooxazolidine derivative represented by the following general formula (I). Here, Fn represents that n functional groups F are substituted in the ring to which it is bonded, n is 1,2,3,4, or 5, F may be the same as or different from each other, and each halogen atom, Nitro group, -R ¹ , -OR ¹ , -SR ¹ or -NR ¹ R ² , wherein R ¹ and R ² may be the same or different from each other, and each is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or a cyclic alkyl group Or a substituted wasteyl group, A and B may be the same or different from each other, each is a carbon atom or a nitrogen atom, and X is Br, Cl or I. A composition for the treatment of cardiac circulatory diseases comprising the isooxazolidine derivative represented by the following structural formula (I) as an active ingredient Here, Fn represents that n functional groups F are substituted in the ring to which it is bonded, n is 1,2,3,4, or 5, F may be the same as or different from each other, and each halogen atom, Nitro group, -R ¹ , -OR ¹ , -SR ¹ or -NR ¹ R ² , wherein R ¹ and R ² may be the same or different from each other, and each is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or a cyclic alkyl group Or a substituted wasteyl group, A and B may be the same as or different from each other, and each is a carbon atom or a nitrogen atom. ※ Note: The disclosure is based on the initial application.