KR910001031A - New porous gelatin particulate carrier having a sponge structure and method for producing same - Google Patents

New porous gelatin particulate carrier having a sponge structure and method for producing same Download PDF

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Publication number
KR910001031A
KR910001031A KR1019890008030A KR890008030A KR910001031A KR 910001031 A KR910001031 A KR 910001031A KR 1019890008030 A KR1019890008030 A KR 1019890008030A KR 890008030 A KR890008030 A KR 890008030A KR 910001031 A KR910001031 A KR 910001031A
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KR
South Korea
Prior art keywords
particulate carrier
size
sponge structure
porous
producing same
Prior art date
Application number
KR1019890008030A
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Korean (ko)
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KR910007847B1 (en
Inventor
김정회
최준호
임현수
Original Assignee
이상수
한국과학기술원
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Publication date
Application filed by 이상수, 한국과학기술원 filed Critical 이상수
Priority to KR1019890008030A priority Critical patent/KR910007847B1/en
Publication of KR910001031A publication Critical patent/KR910001031A/en
Application granted granted Critical
Publication of KR910007847B1 publication Critical patent/KR910007847B1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/40—Apparatus specially designed for the use of free, immobilised, or carrier-bound enzymes, e.g. apparatus containing a fluidised bed of immobilised enzymes

Abstract

내용 없음.No content.

Description

스폰지 구조를 갖는 새로운 다공정 젤라틴 미립 담체 및 그 제조방법New multi-process gelatinous particulate carrier with a sponge structure and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 본 발명에 의하여 얻은 젤라틴을 주재료로 한 신규의 다공성 미립 담체의 주사 현미경 사진(배율 500배)이다.1 is a scanning micrograph (magnification of 500 times) of a novel porous particulate carrier based on gelatin obtained according to the present invention.

Claims (6)

다음 특성을 갖는 스폰지 구조를 갖는 다공성 미립 담체.Porous fine carrier having a sponge structure having the following characteristics. (ㄱ)모양 : 구형(球形), (ㄴ)크기 : 150-500㎛ (ㄷ)구멍 조직의 크기(pore size) : 20-50㎛ (ㄹ)비중 : 1.2-1.6 (ㅁ)표면적 : 7-10㎡/g (ㅂ)세포에 대해 무독성이며, 광학적으로 투명, (ㅅ) 콜라게나제(collagenase), 디스파제(dispase)등의 효소에 의해 분해 가능 (ㅇ) 분말 또는 용액 상태로 살균 가능.(A) Shape: Spherical, (b) Size: 150-500㎛ (C) Pore size: 20-50㎛ (ㄹ) Specific gravity: 1.2-1.6 (ㅁ) Surface area: 7- Nontoxic to 10㎡ / g (iii) cells, optically transparent, (g) degradable by enzymes such as collagenase, dispase, etc. (o) Sterilized in powder or solution state. 발포제 존재하에 젤라틴 용액을 클로로포름/톨루엔(3:7)의 혼합 용매 중에서 교반하여 에멀젼화시킨 다음, 글루타르알데히드를 가하여 가교 결합 반응시키는 것을 특징으로 하는 다음 특성의 스폰지 구조를 갖는 다공성 젤라틴 미립 담체의 제조 방법.The gelatin solution in the presence of a blowing agent is emulsified by stirring in a mixed solvent of chloroform / toluene (3: 7), followed by crosslinking reaction by adding glutaraldehyde to obtain a porous gelatin particulate carrier having a sponge structure having the following characteristics. Manufacturing method. (ㄱ)모양 : 구형(球形), (ㄴ)크기 : 150-500㎛ (ㄷ)구멍 조직의 크기(pore size) : 20-50㎛ (ㄹ)비중 : 1.2-1.6 (ㅁ)표면적 : 7-10㎡/g (ㅂ)세포에 대해 무독성이며, 광학적으로 투명, (ㅅ) 콜라게나제(collagenase), 디스파제(dispase)등의 효소에 의해 분해 가능 (ㅇ) 분말 또는 용액 상태로 살균 가능.(A) Shape: Spherical, (b) Size: 150-500㎛ (C) Pore size: 20-50㎛ (ㄹ) Specific gravity: 1.2-1.6 (ㅁ) Surface area: 7- Nontoxic to 10㎡ / g (iii) cells, optically transparent, (g) degradable by enzymes such as collagenase, dispase, etc. (o) Sterilized in powder or solution state. 제2항에 있어서, 발포제가 입도 20-30㎛의 NaHCO3또는 CaCO3인 것인 방법.The method of claim 2 wherein the blowing agent is NaHCO 3 or CaCO 3 with a particle size of 20-30 μm. 제2항에 있어서, 교반 속도가 300-1000rpm으로 조절됨으로써 다공성 미립 담체의 크기가 150-500㎛으로 조절되는 것인 방법.The method of claim 2, wherein the size of the porous particulate carrier is controlled to 150-500 μm by controlling the stirring speed to 300-1000 rpm. 제2항에 있어서, 혼합 용매에 계면 활성제가 1-4%함유되는 것인 방법.The method of claim 2 wherein the mixed solvent contains 1-4% surfactant. 제2항에 있어서, 미립 담체 제품이 동결 건조 또는 스프레이 건조되는 것인 방법.The method of claim 2, wherein the particulate carrier product is freeze dried or spray dried. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890008030A 1989-06-10 1989-06-10 New sponge-like microporous KR910007847B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019890008030A KR910007847B1 (en) 1989-06-10 1989-06-10 New sponge-like microporous

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019890008030A KR910007847B1 (en) 1989-06-10 1989-06-10 New sponge-like microporous

Publications (2)

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KR910001031A true KR910001031A (en) 1991-01-30
KR910007847B1 KR910007847B1 (en) 1991-10-02

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KR1019890008030A KR910007847B1 (en) 1989-06-10 1989-06-10 New sponge-like microporous

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101295421B1 (en) * 2012-06-12 2013-08-09 최진선 Self-assembly fire pot for multipurpose

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7927626B2 (en) 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
JP5973997B2 (en) 2010-06-01 2016-08-23 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Process for making a dry and stable hemostatic composition
WO2013053755A2 (en) 2011-10-11 2013-04-18 Baxter International Inc. Hemostatic compositions
EP2766059B1 (en) 2011-10-11 2022-11-23 Baxter International Inc. Hemostatic compositions
AR088531A1 (en) 2011-10-27 2014-06-18 Baxter Int HEMOSTATIC COMPOSITIONS
EP2825216B1 (en) 2012-06-12 2015-08-19 Ferrosan Medical Devices A/S Dry haemostatic composition
EP3470094B1 (en) 2013-12-11 2020-07-22 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101295421B1 (en) * 2012-06-12 2013-08-09 최진선 Self-assembly fire pot for multipurpose

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Publication number Publication date
KR910007847B1 (en) 1991-10-02

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