KR910000788A - Method for preparing crystalline α-L-aspartyl-L-phenylalanine methyl ester that can be easily dissolved - Google Patents

Method for preparing crystalline α-L-aspartyl-L-phenylalanine methyl ester that can be easily dissolved Download PDF

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Publication number
KR910000788A
KR910000788A KR1019900009469A KR900009469A KR910000788A KR 910000788 A KR910000788 A KR 910000788A KR 1019900009469 A KR1019900009469 A KR 1019900009469A KR 900009469 A KR900009469 A KR 900009469A KR 910000788 A KR910000788 A KR 910000788A
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South Korea
Prior art keywords
suspension
solution
temperature
apm
aspartyl
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KR1019900009469A
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Korean (ko)
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KR920006562B1 (en
Inventor
마사노부 아지오까
죠지로 히구찌
다께시 오우라
도시오 가또
아끼히로 야마구찌
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사와무라 하루오
미쯔이도오아쯔가가꾸 가부시기가이샤
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Publication of KR910000788A publication Critical patent/KR910000788A/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Abstract

내용 없음No content

Description

쉽게 용해할수 있는 결정성 α-L-아스파르틸-L-페닐알라닌메틸 에스테르의 제조방법Method for preparing crystalline α-L-aspartyl-L-phenylalanine methyl ester that can be easily dissolved

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (9)

α-APM을 수성용매에 용해한 용액을 실질적으로 순수한 α-APM을 수성용매에 현탁시킨 현탁액을 상기 용액보다 낮은 온도로 유지하면서 교반시킨 현탁액에 첨가하는 공정으로 이루어진 것을 특징으로 하는 쉽게 용해할수 있는 결정성 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르(α-APM)의 제조방법.easy dissolving crystals comprising the step of adding a solution in which α-APM is dissolved in an aqueous solvent and adding a suspension of substantially pure α-APM in an aqueous solvent to a stirred suspension while maintaining the temperature at a lower temperature than the solution. A process for preparing the sexual α-L-aspartyl-L-phenylalanine methyl ester (α-APM). 제1항에 있어서, 상기 현탁액의 온도는 그곳에 첨가된 상기 용액의 온도보다 낮은 대략 40~70℃인 것을 특징으로 하는 쉽게 용해할수 있는 결정성 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 제조방법.The method of claim 1, wherein the temperature of the suspension is about 40 ~ 70 ℃ lower than the temperature of the solution added thereto of the easily soluble crystalline α-L-aspartyl-L-phenylalanine methyl ester Manufacturing method. 제1항에 있어서, 용액의 온도는 30-60℃인 것을 특징으로 하는 쉽게 용해할수 있는 결정성 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 제조방법.The method of claim 1, wherein the temperature of the solution is 30-60 ° C. 2. 제1항에 있어서, 현탁액의 온도는 대략 5℃로 유지된 것을 특징으로 하는 쉽게 용해할수 있는 결정성 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 제조방법.The process of claim 1, wherein the temperature of the suspension is maintained at approximately 5 ° C. 5. 제1항에 있어서, 용액내 α-APM의 농도는 포화 또는 거의 포화인 것을 특징으로 하는 쉽게 용해할수 있는 결정성 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 제조방법.The method of claim 1, wherein the concentration of α-APM in the solution is saturated or nearly saturated. 제1항에 있어서, 용액내 α-APM의 양은 현탁액중의 양 보다 실질으로 큰 것을 특징으로 하는 쉽게 용해할수 있는 결정성 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 제조방법.The method of claim 1, wherein the amount of α-APM in solution is substantially larger than the amount in the suspension. 제1항에 있어서, 현탁액중의 α-APM은 실질적으로 순수하며 분말형태인 것을 특징으로 하는 쉽게 용해할수 있는 결정성 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 제조방법.The process for preparing easily soluble crystalline α-L-aspartyl-L-phenylalanine methyl ester according to claim 1, wherein the α-APM in suspension is substantially pure and in powder form. 제1항에 있어서, 용액과 현탄액DP의 수성용매는 물 또는 메틴올과의 혼합물인 것을 특징으로 하는 쉽게 용해할수 있는 결정성 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 제조방법.The method of claim 1, wherein the aqueous solvent of the solution and the suspension DP is a mixture of water or methol. 제1항에 있어서, 상기 현탁액의 온도는 그곳에 첨가된 상기 용액의 온도보다 낮은 대략 40-70℃이고 ; 용액의 온도는 30-60℃이며 ; 현탁액의 온도를 대략 5℃로 유지하고 ; 용액내 α-APM의 농도는 포화 또는 포화근처이며 ; 용액내 α-APM의 양은 현탁액중의 양보다 실질적으로 많으며 ; 현탁액중의 α-APM은 실질적으로 순수하거나 분말형태이며 ; 용액 및 현탁액에서의 수성용매는 물 또는 물과 메탄올과의 혼합물인 것을 특징으로 하는 쉽게 용해할수 있는 결정성 α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 제조방법.The method of claim 1, wherein the temperature of the suspension is approximately 40-70 ° C. lower than the temperature of the solution added thereto; The temperature of the solution is 30-60 ° C .; Maintaining the temperature of the suspension at approximately 5 ° C; The concentration of α-APM in solution is near or near saturation; The amount of α-APM in solution is substantially greater than the amount in the suspension; Α-APM in suspension is substantially pure or in powder form; Aqueous solvents in solutions and suspensions are water or a mixture of water and methanol. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019900009469A 1989-06-26 1990-06-26 Process for preparing readily soluble crystalline alpha-l-aspartyl-l-phenylalanine methyl ester KR920006562B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1-160960 1989-06-26
JP1160960A JPH0327398A (en) 1989-06-26 1989-06-26 Crystallization of alpha-l-aspartyl-l-phenylalanine methyl ester

Publications (2)

Publication Number Publication Date
KR910000788A true KR910000788A (en) 1991-01-30
KR920006562B1 KR920006562B1 (en) 1992-08-08

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KR1019900009469A KR920006562B1 (en) 1989-06-26 1990-06-26 Process for preparing readily soluble crystalline alpha-l-aspartyl-l-phenylalanine methyl ester

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EP (1) EP0405273A3 (en)
JP (1) JPH0327398A (en)
KR (1) KR920006562B1 (en)
AU (1) AU616120B2 (en)
BR (1) BR9002997A (en)
CA (1) CA2019396A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2927070B2 (en) * 1991-05-23 1999-07-28 味の素株式会社 Method for producing α-L-aspartyl-L-phenylalanine methyl ester
ATE145650T1 (en) * 1991-07-19 1996-12-15 Holland Sweetener Co METHOD FOR CRYSTALLIZING ALPHA-L-ASPARTYL-L-PHENYLALANINE METHYL ESTER
JPH05178889A (en) * 1991-10-30 1993-07-20 Ajinomoto Co Inc Method for crystallizing alpha-l-aspartyl-l-phenylalanine methyl ester
JPH08230393A (en) * 1995-02-28 1996-09-10 Ando Electric Co Ltd Marking device with cad
JPH11322788A (en) * 1998-05-08 1999-11-24 Ajinomoto Co Inc New aspartame derivative crystal and its production
JP2000026496A (en) 1998-05-08 2000-01-25 Ajinomoto Co Inc New aspartame derivative crystal and its production
EP0976762A1 (en) * 1998-07-29 2000-02-02 Daesang Corporation Crystallization of Alpha-L-aspartyl-L-phenylalanine methyl ester
US6090972A (en) * 1998-11-12 2000-07-18 Daesang Corporation Crystallization of α-L-aspartyl-L-phenylalanine methyl ester
US6657073B1 (en) 1999-08-18 2003-12-02 Daesang Corporation Crystallization of α-L-aspartyl-L-phenylalanine methyl ester

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227849A (en) * 1983-06-08 1984-12-21 Ajinomoto Co Inc Crystallization and separation of l-alpha-aspartyl-l- phenylalaninemethyl ester
CA2017137A1 (en) * 1989-05-22 1990-11-22 Shigeaki Irino Method for crystallizing &-l-aspartyl-l-phenylalanine methyl ester

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Publication number Publication date
JPH0327398A (en) 1991-02-05
EP0405273A3 (en) 1991-10-30
KR920006562B1 (en) 1992-08-08
AU616120B2 (en) 1991-10-17
EP0405273A2 (en) 1991-01-02
AU5771190A (en) 1991-01-03
CA2019396A1 (en) 1990-12-26
BR9002997A (en) 1991-08-20

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