KR910000767A - Carboxamide Compounds, Pharmaceutical Compositions Containing the Same, and Methods for Making the Same - Google Patents

Carboxamide Compounds, Pharmaceutical Compositions Containing the Same, and Methods for Making the Same Download PDF

Info

Publication number
KR910000767A
KR910000767A KR1019890009119A KR890009119A KR910000767A KR 910000767 A KR910000767 A KR 910000767A KR 1019890009119 A KR1019890009119 A KR 1019890009119A KR 890009119 A KR890009119 A KR 890009119A KR 910000767 A KR910000767 A KR 910000767A
Authority
KR
South Korea
Prior art keywords
group
formula
lower alkyl
phenyl
halogen atom
Prior art date
Application number
KR1019890009119A
Other languages
Korean (ko)
Other versions
KR950006546B1 (en
Inventor
가즈히꼬 쓰쓰미
에이지 우에사까
가요꼬 시노미야
요시히꼬 쓰다
야스오 쇼지
아쓰시 시마
Original Assignee
오오쓰까 아끼히꼬
오오쓰까세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오오쓰까 아끼히꼬, 오오쓰까세이야꾸 가부시끼가이샤 filed Critical 오오쓰까 아끼히꼬
Publication of KR910000767A publication Critical patent/KR910000767A/en
Application granted granted Critical
Publication of KR950006546B1 publication Critical patent/KR950006546B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/62—Isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6544—Six-membered rings
    • C07F9/6547—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

카르복사마이드 화합물, 이를 함유하는 약제학적 조성물 및 이의 제조방법Carboxamide Compounds, Pharmaceutical Compositions Containing the Same, and Methods for Making the Same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (10)

일반식(Ⅰ)에 의해 나타내지는 카르복사미이드 화합물.Carboxamide compound represented by general formula (I). 〔식중 R¹및 R²는 각각 다음과 같으며; 수소원자; 저급 알킬기; 할로겐원자, 카르바모일기, N-(저급알킬)카르바모일기, N-(시클로 알킬)카르바모일기, 페닐고리에 치환체로서 할로겐원자, 저급 알콕시기 또는 저급 알킬기를 가질 수도 있는 N-(페닐)카르바모일기, N-(페닐-저급 알킬)카르바모일기, 저급 알카노일기, 벤조일기, N, N-디(저급 알킬)아미노기, 페닐-티오기, 저급 알킬 티오기, 저급 알킬술피닐기, 페닐술피닐기, 4-페닐피페라지닐카르보닐기, 4-(페닐-저급알킬)피페라지닐 카르보닐기, 페페리디닐 카르보닐기 및 술파모일기 등으로 구성되는 군에서 선택된 1개 내지 3개의 치환체를 가질 수도 있는 페닐기; 저급 알콕시 카르보닐-저급 알킬기; 할로겐 원자와 저급 알콕시카르보닐기로 구성된 군에서 선택 되어지는 1개 내지 3개의 치환체를 가질 수도 있는 피리딜기; N-페닐 아미노기; 치환체로서 할로겐 원자를 가질 수도 있는 나프틸기; 피리미디닐기; 치환체로서 저급알킬기를 가질 수도 있는 이속사졸릴기; 또는 N-프탈아지닐아미노기; 더욱이 R¹및 R²는 결합되어 있는 이웃 질소원자와 함께, 인돌린-1-일기, 치환체로서 할로겐원자를 가질 수도 있는, 1, 2, 3, 4-테트라 히드로퀴놀린-1-일기, 1, 2, 3, 4-테트라히드로 이소퀴놀린-2-일기, 벤즈옥사진 고리 2, 3-위치에서 페닐기를 가질 수도 있는 2, 3-다히드로-4H-1, 4-벤조옥사진-4-일기, 및 벤젠고리에 치환체로서 할로겐 원자를 가질 수도 있는 페노티아진-10-일기등으로 구성된 헤테로시클릭기를 형성하며; 단 R¹및 R²는 동시에 수소원자가 아니어야 하며; 그리고 R¹및 R²중의 하나가 저급 알킬기일 때는, 다른 하나는 치환체로서 할로겐 원자 및 벤조일기를 동시에 갖는 페닐기이며; 또는 R¹및 R²중의 하나가 치환체로서 할로겐 원자를 갖는 페닐기일 때는, 다른 하나는 저급 알콕시카르보닐-저급 알킬기이고; 또한 R¹및 R²중의 하나가 페닐기일때는, 다른 하나는 N-페닐아미노기이며; R³저급 알킬기; 및 X는 산소원자 또는 황원자이다.[Wherein R ¹ and R ² are each as follows; Hydrogen atom; Lower alkyl groups; N- (phenyl) which may have a halogen atom, a lower alkoxy group or a lower alkyl group as a substituent on a halogen atom, carbamoyl group, N- (lower alkyl) carbamoyl group, N- (cycloalkyl) carbamoyl group, or phenyl ring Carbamoyl group, N- (phenyl-lower alkyl) carbamoyl group, lower alkanoyl group, benzoyl group, N, N-di (lower alkyl) amino group, phenyl-thio group, lower alkyl thi group, lower alkylsulfinyl group, It may have 1 to 3 substituents selected from the group consisting of a phenylsulfinyl group, 4-phenylpiperazinylcarbonyl group, 4- (phenyl-lower alkyl) piperazinyl carbonyl group, a peperidinyl carbonyl group and a sulfamoyl group. Phenyl group; Lower alkoxy carbonyl-lower alkyl group; Pyridyl groups which may have 1 to 3 substituents selected from the group consisting of halogen atoms and lower alkoxycarbonyl groups; N-phenyl amino group; Naphthyl group which may have a halogen atom as a substituent; Pyrimidinyl groups; Isoxazolyl group which may have a lower alkyl group as a substituent; Or N-phthalazinylamino group; Furthermore, R 1 and R 2 together with the adjacent nitrogen atoms to which they are attached are indolin-1-yl groups, 1, 2, 3, 4-tetra hydroquinolin-1-yl groups, 1, 2, which may have a halogen atom as a substituent 3, 4-tetrahydro isoquinolin-2-yl group, benzoxazine ring 2, 2, 3-dahydro-4H-1, 4-benzooxazin-4-yl group which may have a phenyl group at 3-position, and Forming a heterocyclic group composed of a phenothiazine-10-yl group or the like which may have a halogen atom as a substituent in the benzene ring; Provided that R¹ and R² must not be hydrogen atoms at the same time; And when one of R 1 and R 2 is a lower alkyl group, the other is a phenyl group having a halogen atom and a benzoyl group simultaneously as a substituent; Or when one of R 1 and R 2 is a phenyl group having a halogen atom as a substituent, the other is a lower alkoxycarbonyl-lower alkyl group; When one of R 1 and R 2 is a phenyl group, the other is an N-phenylamino group; R <3> lower alkyl group; And X is an oxygen atom or a sulfur atom. 제1항에 있어서, R1및 R2가 하기와 같은 카르복사마이드 화합물; 수소원자; 저급 알킬기; 할로겐 원자, N-(저급 알킬)카르바모일기, 저급 알카노 일기 및 벤조일기로 구성된 군에서 선택되어지는 1개 내지 3개의 치환체를 가질 수도 있는 페닐기; 또한 R1및 R2는 결합하고 있는 이웃 질소 원자와 함께, 치환체로서 할로겐원자를 갖는 1, 2, 3, 4-테트라히드로퀴놀린-1-일을 형성하며; 단, R1및 R2는 동시에 수소원자가 아니어야 하며; R3는 저급 알킬기; 및 X는 산소원자 및 황원자이다.〕The compound according to claim 1, wherein R 1 and R 2 are carboxamide compounds as follows; Hydrogen atom; Lower alkyl groups; A phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, an N- (lower alkyl) carbamoyl group, a lower alkano diary and a benzoyl group; And R 1 and R 2 together with the neighboring nitrogen atom to which they are bonded form 1, 2, 3, 4-tetrahydroquinolin-1-yl having a halogen atom as a substituent; Provided that R 1 and R 2 must not be hydrogen atoms at the same time; R 3 is a lower alkyl group; And X is an oxygen atom and a sulfur atom. 제 1항에 있어서, 카르복사마이드 화합물이 하기로 구성된 군에서 선택되어지는 카르복사마이드 화합물; 4-디에톡시포스피노일메틸-N-(4-벤조일-2-브로모페닐)벤자마이드, 4-디에콕시포스피노일메틸-N-(4-클로로-2-벤조일페닐)-N-메틸-벤자마이드; 4-디에톡시포스피노일메틸-N-〔4-클로로-2-(N-메틸 카르바모일)페닐〕벤자마이드, 4-디에톡시포스피노일메틸-N-〔4-브로모-2-(N-메틸 카르바모일)페닐〕벤자마이드, 4-디에톡시포스피노일메틸-N-(4-아세틸-2-크롤로페닐)벤자마이드, 4-디에톡시포스피노일메틸-N-(4-브로모-2-벤조일페닐)벤자마이드, 4-디에톡시포스피노일메틸-N-(4-클로로-2-벤조일페닐)벤자마이드, 및 6-브로모-1-(4-디에톡시포스피노일메틸 벤조일)-1, 2, 3, 4-테트라히드로퀴놀린.The compound of claim 1, wherein the carboxamide compound is selected from the group consisting of: 4-diethoxyphosphinoylmethyl-N- (4-benzoyl-2-bromophenyl) benzamide, 4-diethoxyphosphinoylmethyl-N- (4-chloro-2-benzoylphenyl) -N- Methyl-benzamide; 4-diethoxyphosphinoylmethyl-N- [4-chloro-2- (N-methyl carbamoyl) phenyl] benzamide, 4-diethoxyphosphinoylmethyl-N- [4-bromo-2- (N-methyl carbamoyl) phenyl] benzamide, 4-diethoxyphosphinoylmethyl-N- (4-acetyl-2-chlorophenyl) benzamide, 4-diethoxyphosphinoylmethyl-N- ( 4-bromo-2-benzoylphenyl) benzamide, 4-diethoxyphosphinoylmethyl-N- (4-chloro-2-benzoylphenyl) benzamide, and 6-bromo-1- (4-diethoxy Phosphinoylmethyl benzoyl) -1, 2, 3, 4-tetrahydroquinoline. 일반식(Ⅱ)의 카르복실산 유도체와 일반식(Ⅲ)의 아민과 축합하는 것을 특징으로 하는 일반식(Ⅰa)로 표현되는 카르복사마이드 화합물의 제조방법.A method for producing a carboxamide compound represented by formula (Ia), which is condensed with a carboxylic acid derivative of formula (II) and an amine of formula (III). 〔식에서, R1, R2및 R3는 제1항에서 정의된 바와 동일하다.〕[Wherein, R 1 , R 2 and R 3 are the same as defined in claim 1. 일반식(Ⅳ)의 라르복실산 클로라이드 유도체를 일반식(Ⅲ)의 아민과 반응시킴을 특징으로 하는, 일반식(Ⅰa)로 표현되는 카르복사마이드 화합물의 제조방법.A process for producing a carboxamide compound represented by formula (Ia), characterized by reacting a lar acid chloride derivative of formula (IV) with an amine of formula (III). 〔식에서, R1,R2및 R3는 제 1항에서 정의된 바와 동일하다.〕[Wherein, R 1 , R 2 and R 3 are the same as defined in claim 1. 일반식(Ⅱ)의 카르복실산 유도체를 그들의 혼합 산무수물로 전환시킨 다음 상술한 혼합 산 무수물을 일반식(Ⅲ)아민과 반응시킴을 특징으로 하는 일반식(Ⅰa)로 표현되는 카르복사마이드 화합물의 제조방법.Carboxamide compounds represented by formula (Ia) characterized by converting carboxylic acid derivatives of formula (II) to their mixed acid anhydrides and then reacting the mixed acid anhydrides described above with formula (III) amines Manufacturing method. 〔식에서 R1, R2및 R3는 제 1항에서 정의된 바와 동일하다.〕[Wherein R 1 , R 2 and R 3 are the same as defined in claim 1] 일반식(Ⅴ)의 할로아마이드 유도체를 일반식(Ⅵ)의 아인산 에스테르와 반응시킴을 특징으로 하는, 일반식(Ⅰa)로 표현되는 카르복사마이드 화합물의 제조방법.A process for producing a carboxamide compound represented by formula (Ia), characterized by reacting a haloamide derivative of formula (V) with a phosphite ester of formula (VI). 〔식에서, R1, R2및 R3는 제 1항에서 정의된 바와 동일하고; X는 할로겐 원자이다.〕[Wherein R 1 , R 2 and R 3 are the same as defined in claim 1; X is a halogen atom.] 일반식(Ⅰa)의 카르복사마이드 화합물과 오황화인(ⅤⅡ)와 반응시킴을 특징으로 하는, 일반식(Ⅰb)로 표현되는 카르복사마이드 화합물의 제조방법.A method for producing a carboxamide compound represented by formula (Ib), characterized by reacting with a carboxamide compound of formula (Ia) and phosphorus penta sulfide (VII). P2S5(ⅤⅡ)P 2 S 5 (ⅤⅡ) 〔식에서 R1, R2및 R2는 상기 정의된 바와 동일하다.〕[Wherein R 1 , R 2 and R 2 are the same as defined above.] 활성 성분으로서 제1항에서 청구된 바의 일반식(Ⅰ)의 카르복사마이드 화합물을 함유하는 과지질 혈증의 치료 및/또는 예방용 약제학적 조성물.A pharmaceutical composition for the treatment and / or prophylaxis of hyperlipidemia comprising the carboxamide compound of formula (I) as claimed in claim 1 as an active ingredient. 일반식(Ⅰ)로 표현되는 카르복사마이드 화합물을, 활성 성분으로 0,05내지 80㎎/㎏ 체중/1일의 투여율로 함유하는 제9항에서 청구된 약제학적 조성물을 투여함을 특징으로 하는 과지질 혈증의 치료 및/또는 예방방법.It is characterized by administering the pharmaceutical composition as claimed in claim 9 containing the carboxamide compound represented by the general formula (I) at an dosage of 0,05 to 80 mg / kg body weight / day as an active ingredient. A method of treating and / or preventing hyperlipidemia. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890009119A 1988-06-29 1989-06-29 Carboxamide compounds, process for preparing the same and pharmaceutical composition containing the same KR950006546B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP63-163082 1988-06-29
JP16308288 1988-06-29
JP01-152784 1989-06-15
JP15278489 1989-06-15
JP1160171A JPH0745508B2 (en) 1988-06-29 1989-06-21 Carboxamide derivative
JP01-160171 1989-06-21

Publications (2)

Publication Number Publication Date
KR910000767A true KR910000767A (en) 1991-01-30
KR950006546B1 KR950006546B1 (en) 1995-06-16

Family

ID=26481598

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890009119A KR950006546B1 (en) 1988-06-29 1989-06-29 Carboxamide compounds, process for preparing the same and pharmaceutical composition containing the same

Country Status (2)

Country Link
JP (1) JPH0745508B2 (en)
KR (1) KR950006546B1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW260664B (en) * 1993-02-15 1995-10-21 Otsuka Pharma Factory Inc
US5985858A (en) * 1995-12-27 1999-11-16 Otsuka Pharmaceutical Factory, Inc. Phosphonic diester derivatives
IL156315A0 (en) * 2000-12-07 2004-01-04 Cv Therapeutics Inc Abca-1 elevating compounds
DE212012000278U1 (en) 2012-06-20 2015-01-27 CosmoCare Ltd. clothing
DE202012013149U1 (en) 2012-06-20 2015-08-03 CosmoCare Ltd. clothing

Also Published As

Publication number Publication date
JPH0745508B2 (en) 1995-05-17
JPH03109393A (en) 1991-05-09
KR950006546B1 (en) 1995-06-16

Similar Documents

Publication Publication Date Title
NO904134D0 (en) PROCEDURE FOR THE PREPARATION OF PYRAZOLD DERIVATIVES.
IL107426A0 (en) Heterocyclic compounds, processes for the preparation thereof, and pharmaceutical compositions containing the same
FI95699B (en) The method produces a pharmacologically valuable benzodiazepine
NO903438L (en) PROCEDURE FOR THE PREPARATION OF TIAZOLD DERIVATIVES.
SG45259A1 (en) New thiazolybenzofuran derivatives processes for the preparation thereof and pharmaceutical composition comprising the same
NO173867C (en) Analogous Procedures for the Preparation of Therapeutically Active Benzamides
KR910000767A (en) Carboxamide Compounds, Pharmaceutical Compositions Containing the Same, and Methods for Making the Same
NO168707C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE HETEROTETRACYCLIC LACTAM DERIVATIVES.
FI89594C (en) PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICAL PROPERTIES OF PYRROLIDINE INFOERING
NO165593C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF NEW TETRACYCLIC INDOLIDATE DERIVATIVES.
CA2111460A1 (en) Tetrahydrobenzazepine derivatives which inhibit lipoxygenase
PT84760A (en) Heterocyclic compounds
IL97611A (en) Heterocyclic compounds, their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20070608

Year of fee payment: 13

LAPS Lapse due to unpaid annual fee