KR910000429B1 - First aid bandage - Google Patents

Abstract

Carboxymethylalginates ae processed into fibrous material. And the fibrous material are made into a nonwoven fabric, then into a gauze. The gauze is used as a disposable medical bandage. This bandage features fast coagulation of blood, least skin irritation, easy abosorption of gel residues into human body, retarding germ contamination, easy applicability to large wounds, etc.

Description

Disposable bandage with hemostatic gauze

The present invention relates to a disposable bandage for producing gauze by fibrizing carboxymethylalkynate, which is a kind of hemostatic material of the present invention, and using the same in a disposable band.

Disposable bandages are generally used to protect the skin from wounds such as burns, abrasions, cuts or inflammation from the outside, to prevent secondary bacterial infections, and to promote wound healing. The properties of these bandage-enabled materials are such that they can rapidly bleed, the material must be non-toxic, non-irritating to skin wounds and have good tissue and compatibility. In addition, a material having antibacterial properties that can prevent bacterial infection, can be absorbed into the body by contact with body fluids, and furthermore, a material capable of quickly rejuvenating wounds by promoting regeneration cells is desirable.

Currently used disposable bandage gauze is made of materials such as cotton gauze, ester fiber gauze, cellulose oxide gauze, collagen gauze.

The most widely used cotton gauze is very inexpensive compared to other gauze. However, there are many shortcomings for wound protection and treatment.

Cotton gauze can not bleed quickly due to abrasions, cuts, etc., has the disadvantage of causing irritation to sensitive skin such as burns, inflammation. In addition, it is comb-absorbed to the human body, and the cotton gauze and wounds are adhered to each other by the coagulated blood, so skin pain or capillaries may be ruptured when the bandage is removed.

Ester fiber gauze is used to make up for the disadvantages of cotton gauze. The composition of the gauze is to wrap a porous P.T film in a nonwoven fabric produced by needle punches of ester fiber and use it as gauze. Ether fiber gauze is cheaper than cotton gauze, and absorbs bleeding porous PE film, so there is no adhesive phenomenon due to blood coagulation between wound and gauze. However, the porous P.T film lacks adhesion to the wound, causing irritation or lifting of the skin at joints or areas of heavy movement, and also slowing blood coagulation and preventing skin shrinkage during wound regeneration. Cellulose oxide gauze can coagulate blood due to hemostatic performance, but it is expensive for use as disposable bandage gauze, and there is a problem of low blood absorption, and blood absorption in case of using proteinaceous gauze such as collagen gauze Over clotting performance, wound regeneration ability is excellent, but the price is too expensive and there is a problem that causes wound irritation due to blood coagulation due to lack of gel formation ability.

In order to solve the above problems, the present invention has succeeded in solving the above problems by fiberizing carboxymethyl alkynate, making it a soft nonwoven fabric, and using it as a disposable bandage gauze. That is, when using the carboxymethyl alginate gauze in the disposable bandage has the following advantages.

Calcium ion, which is a blood coagulation factor, is chelated in the molecular structure, and when it comes into contact with blood, calcium ions act as a blood coagulation factor, thereby rapidly coagulating blood. In addition, by forming a viscous gel in contact with blood or body fluids to minimize the skin irritation by softening the wound on the joints or moving parts.

When removing disposable bandage, the gauze remains on the skin in a gel state, so there is no pain because the capillaries are not ruptured and the remaining gel is absorbed in vivo without removing it. It plays a role in suppressing bacterial infection and heals cleanly without any shrinkage of skin during wound regeneration.

In addition, there is a great amount of blood absorption can be used for a relatively large upper body.

The carboxymethyl alkynates of the present invention can be obtained by reacting alcinate with caustic soda and chloroacetic acid in a dispersion medium. Hydrogen ions in the alginate hydroxyl group are replaced with sodium ions by the addition of caustic soda.

The water produced by this reaction is absorbed in the dispersion medium, thereby minimizing the reverse reaction due to the reversible reaction.

By adding chloroacetic acid to an alginate substituted with sodium ions, a product containing a carboxymethyl group can be obtained.

This reaction can increase the amount of carboxyl groups in the alginate molecular chain by etherification reaction by introducing carboxymethyl groups into the alginate salts, thereby further increasing the functions of the coagulation, solubility, and gel formation of the alginate salts.

The physical properties and properties of the synthesized carboxymethyl alginate are as follows.

It is made into a 2% aqueous solution of carboxymethyl alginate synthesized as described above and wet-spun in 1% calcium chloride demand solution to obtain a fiber.

The prepared fibers are made of gauze through a needle punch, then washed several times with an alcoholic washing solution, dried and used as a gauze for bandage once. A method of synthesizing carboxymethyl alginnai by adding caustic soda and chloroacetic acid to the alganate is the same as in Example 1.

Example 1

720 g of alginate was added to a rotary stirring reaction, and 3,000 g of 40% ethanol and 1,500 g of toluene were added and vigorously stirred to disperse the alginate. The stirring was stopped and 30% caustic soda was added at a 5-minute interval for 30 minutes and then stirred for 30 minutes. Chloroacetic acid was then slowly added to maintain the temperature at 40 ° C. and pH was adjusted to add a certain amount of sodium carbonate until the pH was 6-8, followed by stirring. After stirring for 50 minutes, the temperature was cooled to 10 ° C or lower.

The dispersion was removed, washed three times with more than 80% of ethane, and dried in a 120 ° C. dryer.

The carboxymethyl alginate thus obtained was fibrous by wet spinning in a general 1% aqueous calcium chloride solution.

The fibers are cut to about 5 centimeters and gauze through a needle punch.

The properties of the gauze in the treatment composition of the reactants are shown in Table 1.

TABLE 1

Comparative Example 1

The results of carboxymethyl algin gauze, cotton gauze, ester gauze, cellulose oxide gauze, collagen gauze, etc., measured by blood clotting test method are shown in Table 2.

TABLE 2

It can be seen that carboxymethyl alginate gauze has the shortest blood clotting time.

{Comparative Example 2]

Comparative Example 1. The results of comparative experiments of the water absorbency of the sample by the tea bag method are shown in Table 3.

TABLE 3

Carboxymethyl alginate gauze has less water absorption than collagen gauze, but it can be seen that the water absorption is superior to other gauze.

Comparative Example 3

Comparative Example 1. The gel-forming ability of the sample was dissolved in physiological saline at 37 ° C for 12 hours, and the amount of the dissolved solution was calculated as the difference between the initial weight and the dissolved weight.

TABLE 4

It can be seen that the solubility of the carboxymethyl alginate gauze is the best.

Claims (1)

Disposable bandage with hemostatic gauze of carboxymethyl alginate.