KR900700097A - Antitumor Platinum-Amine-Sulfoxide - Google Patents

Antitumor Platinum-Amine-Sulfoxide

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Publication number
KR900700097A
KR900700097A KR1019890702309A KR890702309A KR900700097A KR 900700097 A KR900700097 A KR 900700097A KR 1019890702309 A KR1019890702309 A KR 1019890702309A KR 890702309 A KR890702309 A KR 890702309A KR 900700097 A KR900700097 A KR 900700097A
Authority
KR
South Korea
Prior art keywords
platinum complex
alkyl
phenyl
alkenyl
group
Prior art date
Application number
KR1019890702309A
Other languages
Korean (ko)
Inventor
피. 파렐 니콜라스
Original Assignee
원본 미기재
더 유니버시티 오브 버몬트 랜드 스테이트 어그리컬츄럴 칼레지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본 미기재, 더 유니버시티 오브 버몬트 랜드 스테이트 어그리컬츄럴 칼레지 filed Critical 원본 미기재
Publication of KR900700097A publication Critical patent/KR900700097A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Abstract

내용 없음No content

Description

항종양제 백금-아민-설폭시드Antitumor Platinum-Amine-Sulfoxide

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (16)

다음 일반식의 백금착화합물.Platinum complex compound of the following general formula. 상기식에서는 비덴테이트 아민이고, Z'NH2는 모노덴테이트 아민이며, R' 및 R"는 상이한 유기 그룹이고, X-는 약제학적으로 허용되는 음이온이다.In the above formula Is a bidentate amine, Z'NH 2 is a monodentate amine, R 'and R "are different organic groups, and X - is a pharmaceutically acceptable anion. 제1항에 있어서, 다음 일반식을 갖는 백금 착화합물.The platinum complex of claim 1 having the following general formula. 또는or 제1항에 있어서, 다음 일반식을 갖는 백금 착화합물.The platinum complex of claim 1 having the following general formula. 또는or 제1항에 있어서, R' 및 R" 는 독립적으로 페닐, 카복시 C1-C4알킬 에스테르 또는 C2-C6알케닐로 임의 치환된 C1-C6알킬, 페닐, 카복시, C1-C6알킬 에스테르 또는 C2-C6알케닐로 임의 치환된 C3-C7시클로알킬, 그리고 C1-C4알킬, C1-C4알콕시, 할로겐, 히드록시 C2-C4알케닐, 카복시 C1-C4알킬 에스테르, 아미노, C1-C4알킬 아미노 및 디(C1-C4알킬) 아미노로 구성된 그룹에서 선택된 치환체로 임의 치환된 페닐로 구성된 그룹으로부터 선택된 백금 착화합물.The compound of claim 1, wherein R ′ and R ″ are independently C 1 -C 6 alkyl, phenyl, carboxy, C 1 − optionally substituted with phenyl, carboxy C 1 -C 4 alkyl ester or C 2 -C 6 alkenyl. C 3 -C 7 cycloalkyl optionally substituted with C 6 alkyl ester or C 2 -C 6 alkenyl, and C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, hydroxy C 2 -C 4 alkenyl And a platinum complex selected from the group consisting of phenyl optionally substituted with a substituent selected from the group consisting of carboxy C 1 -C 4 alkyl esters, amino, C 1 -C 4 alkyl amino and di (C 1 -C 4 alkyl) amino. 제4항에 있어서, Z'가 C3-C5시클로알킬 또는 C3-C10알킬이고, 각 알킬은 C1-C6알킬, C2-C6알케닐, 페닐 및 치환된 페닐로 구성된 그룹에서 선택된 치환체로 임의 치환되는 백금 착화합물.5. The compound of claim 4, wherein Z ′ is C 3 -C 5 cycloalkyl or C 3 -C 10 alkyl, each alkyl consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, phenyl, and substituted phenyl Platinum complex compounds optionally substituted with substituents selected from the group. 제5항에 있어서, Z'는 시클로알킬인 백금 착화합물.The platinum complex of claim 5 wherein Z 'is cycloalkyl. 제6항에 있어서, Z'는 시크로 펜틸 또는 시크로 헥실인 백금 착화합물.The platinum complex of claim 6 wherein Z 'is cyclopentyl or cyclohexyl. 제4항에 있어서, Z가 탄소수 3 내지 10의 알킬렌 그룹, 탄소수 3 내지 10의 시클로알킬렌 그룹, 페닐렌 또는 피리딜인 백금 착화합물.The platinum complex according to claim 4, wherein Z is an alkylene group having 3 to 10 carbon atoms, a cycloalkylene group having 3 to 10 carbon atoms, phenylene or pyridyl. 제8항에 있어서, Z가 시클로헥실리덴인 백금 착화합물.The platinum complex of claim 8 wherein Z is cyclohexylidene. 제4항에 있어서, R'가 메틸이고, R" 는 페닐, 톨일 또는 벤질인 백금 착화합물.5. A platinum complex according to claim 4, wherein R 'is methyl and R "is phenyl, tolyl or benzyl. 제1항에 있어서, X가 Cl,Br 또는 NO3인 백금 착화합물.The platinum complex of claim 1 wherein X is Cl, Br or NO 3 . 제11항에 있어서, X가 NO3인 백금 착화합물.The platinum complex of claim 11 wherein X is NO 3 . 제1항에 있어서, 광학활성을 갖는 백금 착화합물.The platinum complex of claim 1 having optical activity. 제1항에 따른 백금 착화합물을 항종양 유효량과 약제학적으로 허용되는 담체와 배합하여 이루어진 항종양 조성물.An anti-tumor composition comprising the platinum complex compound according to claim 1 combined with an effective anti-tumor amount and a pharmaceutically acceptable carrier. 제14항에 있어서, 백금 착화합물을 1 내지 500㎎함유하는 항종양 조성물.The anti-tumor composition according to claim 14, which contains 1 to 500 mg of a platinum complex. 제1항에 따른 백금 착화합물의 항종양 유효량을 백금 요법에 대해 감수성 종양을 가진 동물에 투여하는 것으로 이루어진 상기 동물의 치료방법.A method of treating an animal comprising administering an anti-tumorally effective amount of the platinum complex according to claim 1 to an animal having a tumor sensitive to platinum therapy. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890702309A 1988-04-13 1989-04-12 Antitumor Platinum-Amine-Sulfoxide KR900700097A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18095688A 1988-04-13 1988-04-13
US180,956 1988-04-13
PCT/US1989/001520 WO1989009598A1 (en) 1988-04-13 1989-04-12 Platinum-amine-sulfoxides as anti-tumor agents

Publications (1)

Publication Number Publication Date
KR900700097A true KR900700097A (en) 1990-08-11

Family

ID=22662298

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890702309A KR900700097A (en) 1988-04-13 1989-04-12 Antitumor Platinum-Amine-Sulfoxide

Country Status (7)

Country Link
EP (1) EP0409894A4 (en)
KR (1) KR900700097A (en)
AU (1) AU3447289A (en)
ES (1) ES2013433A6 (en)
GR (1) GR890100246A (en)
WO (1) WO1989009598A1 (en)
ZA (1) ZA892706B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1238078B (en) * 1990-01-31 1993-07-05 Silvano Spinelli CIS-PLATINUM COMPLEXES WITH AMINES AND CHELANTS SULFINYLCARBOSSILATES
NL9001639A (en) * 1990-07-19 1992-02-17 Amc Amsterdam PT-CONTAINING COMPOUND, METHOD FOR PREPARING IT, AND USE OF SUCH COMPOUNDS.
ATE360024T1 (en) * 2002-08-29 2007-05-15 Jih-Ru Hwu ORGANOMETAL COMPLEX
KR20180099734A (en) * 2015-12-22 2018-09-05 니폰 가야꾸 가부시끼가이샤 Polymer conjugate of platinum (II) complex with sulfoxide derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55144422A (en) * 1979-04-28 1980-11-11 Nippon Kayaku Co Ltd Purification of cis-dichlorodiammineplatinum(2)
US4808730A (en) * 1987-06-23 1989-02-28 American Cyanamid Company Synthesis of cisplatin analogs

Also Published As

Publication number Publication date
AU3447289A (en) 1989-11-03
ES2013433A6 (en) 1990-05-01
WO1989009598A1 (en) 1989-10-19
ZA892706B (en) 1989-11-29
GR890100246A (en) 1990-01-31
EP0409894A1 (en) 1991-01-30
EP0409894A4 (en) 1992-12-02

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