KR900700096A - Organic complexes applied locally - Google Patents

Abstract

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Description

Organic complexes applied locally

As this is a public information case, the full text was not included.

Claims (28)

A pharmaceutical composition for topical application comprising a gold compound (as defined above) and a pharmaceutically acceptable carrier having a viscosity greater than the viscosity of water. The composition of claim 1 wherein the gold compound is lipid soluble. 3. The composition of claim 2 wherein the gold compound is in oxidation state I. The composition according to claim 3, wherein the gold compound has the following structure. Wherein X is H, acetyl or promil and A is -S-Au-PR or -Y- (CH ₂ ) n S-AuPR ₃ , where R is H, alkyl, aryl or heterocyclic and substituted or unsubstituted May not); Y is O or S; n is 1 to 12. The composition according to claim 4, wherein the composition has the following structural formula. The composition of any one of the preceding claims, further comprising a corticosteroid. The composition of claim 6, wherein the corticosteroid is betamethasone dipropionate. A pharmaceutical composition for topical application, wherein a gold compound having the following structural formula is included with betamethasone dipropionate and a pharmaceutically acceptable carrier. Wherein X is H, acetyl or formyl and A is -S-Au-PR ₃ or -Y- (CH ₂ ) n S-AuPR ₃ (where R is H, alkyl, aryl or a heterocycle and is substituted or substituted May not be); Y is O or S; n is 1 to 12. The pharmaceutical composition according to claim 8, wherein the gold compound has the following structural formula. The pharmaceutical composition according to claim 9, wherein the concentration of the gold compound is between 0.05 and 0.25% by weight of the total composition. The composition of any one of the preceding claims wherein the carrier is an ointment. Local application of gold compounds for the treatment of local or systematic inflammatory conditions. 13. The topical application according to claim 12, wherein the state is psoriasis. Local application of gold compound as antibacterial agent. The topical application according to claim 14, wherein the bacterium is Gram-positive. Use of the composition according to any one of claims 1 to 11 in the treatment of psoriasis. Use of a composition according to claim 5 in the treatment of psoriasis. 10. The use of claim 9 in the treatment of psoriasis. A method of treating local or systemic inflammatory symptoms, comprising applying a pharmaceutical composition containing gold compounds (as defined above) to or near an inflammatory site in a patient suffering from local or systemic inflammatory symptoms. 20. The method of claim 19, comprising applying the pharmaceutical composition according to any one of claims 1 to 11 near or near the inflammation site. 20. The method of claim 19, wherein the inflamed site is a site in a patient suffering from psoriasis. A method of treating a bacterial infection consisting of applying a pharmaceutical composition containing a gold compound (as defined above) to a bacterial infection site. The method of claim 22, wherein the composition is according to claim 1. A method of treating psoriasis, comprising applying a pharmaceutical composition according to claim 5 near or near an infected site of a patient suffering from psoriasis. A method of treating psoriasis, comprising applying a pharmaceutical composition according to claim 9 near or near an infected site of a patient suffering from psoriasis. A method of treating bacterial infection, comprising applying the composition of any one of claims 1 to 11 to a site in need of bacterial infection treatment. A method for treating bacterial infection, comprising applying the pharmaceutical composition according to claim 5 near or near an infected site of a patient. A method of treating bacterial infection comprising applying the pharmaceutical composition of claim 9 to or near an infected site of a patient. ※ Note: The disclosure is based on the initial application.