KR900014376A - Imidazo pyridine compound and preparation method thereof - Google Patents

Imidazo pyridine compound and preparation method thereof Download PDF

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Publication number
KR900014376A
KR900014376A KR1019900003235A KR900003235A KR900014376A KR 900014376 A KR900014376 A KR 900014376A KR 1019900003235 A KR1019900003235 A KR 1019900003235A KR 900003235 A KR900003235 A KR 900003235A KR 900014376 A KR900014376 A KR 900014376A
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KR
South Korea
Prior art keywords
methylimidazo
pyridine
methyl
benzylamino
propynyl
Prior art date
Application number
KR1019900003235A
Other languages
Korean (ko)
Inventor
유이치 시오카와
마사노부 나가노
히로미치 이타니
Original Assignee
후지사와 토모키치로
후지사와 야쿠힝 코교 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898905762A external-priority patent/GB8905762D0/en
Priority claimed from GB898924994A external-priority patent/GB8924994D0/en
Application filed by 후지사와 토모키치로, 후지사와 야쿠힝 코교 가부시기가이샤 filed Critical 후지사와 토모키치로
Publication of KR900014376A publication Critical patent/KR900014376A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

이미다조 피리딘 화합물 및 그것의 제조방법Imidazo pyridine compound and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

8-[2-메틸-6-{(S)-2-히드록시프로피오닐아미드}벤질아미노]-3-(2-프로피닐)-2-메틸이미다조[1,2-a] 피리딘 및 8-[2-메틸-6-{(R)-2-히드록시프로피오닐아미드}벤질아미노]-3-(2-프리피닐)-2-메틸이미다조[1,2-a] 피리딘 으로 구성된 군으로부터 선택되는 이미다조피리딘 화합물 또는 그것의 약학적 허용염.8- [2-methyl-6-{(S) -2-hydroxypropionylamide} benzylamino] -3- (2-propynyl) -2-methylimidazo [1,2-a] pyridine and 8- [2-methyl-6-{(R) -2-hydroxypropionylamide} benzylamino] -3- (2-prepinyl) -2-methylimidazo [1,2-a] pyridine An imidazopyridine compound selected from the group consisting of or a pharmaceutically acceptable salt thereof. 제 1항에 있어서, 8-[2-메틸-6-{(S)-2-히드록시프로피오닐아미드}벤질아미노]-3-(2-프로피닐)-2-메틸이미다조[1,2-a] 피리딘인 화합물.A compound according to claim 1, wherein 8- [2-methyl-6-{(S) -2-hydroxypropionylamide} benzylamino] -3- (2-propynyl) -2-methylimidazo [1, 2-a] a pyridine compound. ⅰ) 8-[2-메틸-6-{(S)-2-(보호히드록시)프로피오닐아미노}벤질아미노]-3-(2-프로피닐)-2-메틸이미다조[1,2-a] 피리딘 또는 그것의 염의 히드록시 보호기 제거반응에 의해 8-[2-메틸-6-{(S)-2-히드록시프로피오닐아미노}벤질아미노]-3-(2-프리피닐)-2-메틸이미다조[1,2-a] 피리딘 또는 그것의 염을 제조하거나, 또는 ⅱ) 8-[2-메틸-6-{(R)-2-(보호히드록시)프로피오닐아미노}벤질아미노]-3-(2-프로피닐)-2-메틸이미다조[1,2-a] 피리딘 또는 그것의 염의 히드록시 보호기 제거반응에 의해 8-[2-메틸-6-{(R)-2-히드록시프로피오닐아미노}벤질아미노]-3-(2-프리피닐)-2-메틸이미다조[1,2-a] 피리딘 또는 그것의 염을 제조하는 것으로 구성되는 8-[2-메틸-6-{(S)-히드록시프로피오닐아미노}벤질아미노]-3-(2-프리피닐)-2-메틸이미다조[1,2-a] 피리딘 및 8-[2-메틸-6-{(R)-2-히드록시프로피오닐아미노}벤질아미노]-3-(2-프로피닐)-2-메틸이미다조[1,2-a] 피리딘 또는 그것의 염으로 구성된 군으로부터 선택되는 이미다조피리딘 화합물의 제조방법.Iii) 8- [2-methyl-6-{(S) -2- (protectionhydroxy) propionylamino} benzylamino] -3- (2-propynyl) -2-methylimidazo [1,2 -a] 8- [2-methyl-6-{(S) -2-hydroxypropionylamino} benzylamino] -3- (2-pripinyl)-by hydroxy protecting group removal of pyridine or salts thereof To prepare 2-methylimidazo [1,2-a] pyridine or a salt thereof, or ii) 8- [2-methyl-6-{(R) -2- (protectionhydroxy) propionylamino} Benzylamino] -3- (2-propynyl) -2-methylimidazo [1,2-a] pyridine or a salt thereof to remove the hydroxy protecting group and react with 8- [2-methyl-6- { ) -2-hydroxypropionylamino} benzylamino] -3- (2-prepinyl) -2-methylimidazo [1,2-a] pyridine or a salt thereof, 8- [ 2-methyl-6-{(S) -hydroxypropionylamino} benzylamino] -3- (2-pripinyl) -2-methylimidazo [1,2-a] pyridine and 8- [2- Methyl-6-{(R) -2-hydroxypropionylamino} benzyl A method for producing an imidazopyridine compound selected from the group consisting of amino] -3- (2-propynyl) -2-methylimidazo [1,2-a] pyridine or salts thereof. 약학적 허용담체와의 혼합물로 활성성분으로서 제 1항의 화합물 또는 그것의 약학적 허용염으로 구성되는 약학적 조성물.A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof as an active ingredient in admixture with a pharmaceutically acceptable carrier. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019900003235A 1989-03-13 1990-03-12 Imidazo pyridine compound and preparation method thereof KR900014376A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8905762.4 1989-03-13
GB898905762A GB8905762D0 (en) 1989-03-13 1989-03-13 Imidazopyridine compound and a process for preparation thereof
GB898924994A GB8924994D0 (en) 1989-11-06 1989-11-06 Imidazopyridine compound and a process for preparation thereof
GB8924994.0 1989-11-06

Publications (1)

Publication Number Publication Date
KR900014376A true KR900014376A (en) 1990-10-23

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ID=26295085

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Application Number Title Priority Date Filing Date
KR1019900003235A KR900014376A (en) 1989-03-13 1990-03-12 Imidazo pyridine compound and preparation method thereof

Country Status (2)

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JP (1) JPH02270873A (en)
KR (1) KR900014376A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA48122C2 (en) * 1993-10-11 2002-08-15 Бік Гульден Ломберг Хеміше Фабрік Гмбх IMIDAZO[1,2-a]PYRIDINE ALKOXYALKYL CARBAMATES, A PROCESS OF THEIR PREPARING AND A DRUG ON THEIR BASIS
CA2196076A1 (en) * 1994-07-28 1996-02-08 Gerhard Grundler Acyl imidazopyridines
EP0882048B1 (en) * 1996-01-26 2005-05-04 ALTANA Pharma AG 3-alkylimidazopyridines
AU1545297A (en) * 1996-01-26 1997-08-20 Byk Gulden Imidazopyridine halides
UA80393C2 (en) 2000-12-07 2007-09-25 Алтана Фарма Аг Pharmaceutical preparation comprising an pde inhibitor dispersed on a matrix
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient

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Publication number Publication date
JPH02270873A (en) 1990-11-05

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