KR900004712A - Method of preparing hydrosmine - Google Patents

Method of preparing hydrosmine Download PDF

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Publication number
KR900004712A
KR900004712A KR1019880012310A KR880012310A KR900004712A KR 900004712 A KR900004712 A KR 900004712A KR 1019880012310 A KR1019880012310 A KR 1019880012310A KR 880012310 A KR880012310 A KR 880012310A KR 900004712 A KR900004712 A KR 900004712A
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KR
South Korea
Prior art keywords
hydroxyethyl
diosmin
diosmine
hydrosmine
producing
Prior art date
Application number
KR1019880012310A
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Korean (ko)
Other versions
KR970002658B1 (en
Inventor
오르할레스 베네로 아우렐리오
모스께라 뻬스따냐 라몬
Original Assignee
자비에르 가르시아 데 라마
파브리까 에스파뇨라 데 쁘로독또스 까마꼬스 이 빠르마세우띠꼬스 소시에다드 아노니마
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Application filed by 자비에르 가르시아 데 라마, 파브리까 에스파뇨라 데 쁘로독또스 까마꼬스 이 빠르마세우띠꼬스 소시에다드 아노니마 filed Critical 자비에르 가르시아 데 라마
Publication of KR900004712A publication Critical patent/KR900004712A/en
Application granted granted Critical
Publication of KR970002658B1 publication Critical patent/KR970002658B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones

Abstract

내용 없음No content

Description

하이드로스민의 제조방법Method of preparing hydrosmine

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

디오스민을 에텔렌옥사이드와 반응시키는 것으로 이루어지는 하이드로스민의 제조방법.A method for producing hydrosmine comprising reacting diosmin with ethylene oxide. 제1항에 있어서, 수산화나트륨이 존재하는(디오스민 몰당 0.2 내지 1몰)수용성 매질 내에서, 50내지 80℃의 온도로, 과잉의 에틸렌옥사이드(디오스민 몰당 5 내지 10몰)과 디오스민의 반응을 실시하는 것을 특징으로 하는 하이드로스민의 제조방법.The reaction of excess ethylene oxide (5 to 10 moles per mole of diosmin) with diosmin at a temperature of 50 to 80 ° C. in an aqueous medium in which sodium hydroxide is present (0.2 to 1 mole per mole of diosmin). Method for producing a hydrosmine, characterized in that to carry out. 제1항 내지 2항중 어느 한 항에 있어서, 디오스민을 5-0(β-하이드록시에틸)-디오스민, 3'-0-(β-하이드록시에틸-디오스민 및 5,3'-디-0-(β-하이드록시에틸)-디오스민이 각각 17 내지 27%, 28 내지 38% 및 15 내지 25%로 존재하는 혼합물인 0-β-하이드록시에틸 디오스민의 표준적인 혼합물로 변화시키는 것을 특징으로 하는 하이드로스민의 제조방법.3. The diosmin according to claim 1, wherein the diosmin is 5-0 (β-hydroxyethyl) -diosmine, 3′-0- (β-hydroxyethyl-diosmine and 5,3′-di. Characterized by changing to a standard mixture of 0-β-hydroxyethyl diosmin, a mixture wherein -0- (β-hydroxyethyl) -diosmine is present at 17 to 27%, 28 to 38% and 15 to 25%, respectively A method for producing hydrosmine. 하드로스민의 제조방법.Method for preparing hydramine. 5-0(β-하이드록시에틸)-디오스민, 3'-0-(β-하이드록시에틸)-디오스민 및 5,3'-디-0-(β-하이드록시에틸)-디오스민이 각각 17 내지 27%, 28 내지 38% 및 15 내지 25%로 존재하는 0-β-하이드록시에틸 디오스민의 표준적인 혼합물로 정의되는 결과물인 하이드로스민.5-0 (β-hydroxyethyl) -diosmine, 3'-0- (β-hydroxyethyl) -diosmine and 5,3'-di-0- (β-hydroxyethyl) -diosmine, respectively Hydrosmine, the result defined as a standard mixture of 0-β-hydroxyethyl diosmin present in 17-27%, 28-38% and 15-25%. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019880012310A 1988-05-10 1988-09-23 Process for the preparation of hydrosmin KR970002658B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE8801445 1987-08-10
ES8801445 1988-05-10
ES8801445A ES2009914A6 (en) 1988-05-10 1988-05-10 Hydrosmine prepn.

Publications (2)

Publication Number Publication Date
KR900004712A true KR900004712A (en) 1990-04-12
KR970002658B1 KR970002658B1 (en) 1997-03-07

Family

ID=8256248

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880012310A KR970002658B1 (en) 1988-05-10 1988-09-23 Process for the preparation of hydrosmin

Country Status (3)

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KR (1) KR970002658B1 (en)
ES (1) ES2009914A6 (en)
PT (1) PT88124B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103408621B (en) * 2013-08-16 2015-09-30 李玉山 The synthesis technique of a kind of extra large Qu Siming
CN103601773B (en) * 2013-11-12 2016-08-17 李玉山 The preparation technology of the bright crude drug of Hai Qusi

Also Published As

Publication number Publication date
KR970002658B1 (en) 1997-03-07
PT88124B (en) 1995-03-01
PT88124A (en) 1990-05-31
ES2009914A6 (en) 1989-10-16

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