KR900000374A - N-포스포노메틸 글리신의 제조방법 - Google Patents
N-포스포노메틸 글리신의 제조방법 Download PDFInfo
- Publication number
- KR900000374A KR900000374A KR1019880007187A KR880007187A KR900000374A KR 900000374 A KR900000374 A KR 900000374A KR 1019880007187 A KR1019880007187 A KR 1019880007187A KR 880007187 A KR880007187 A KR 880007187A KR 900000374 A KR900000374 A KR 900000374A
- Authority
- KR
- South Korea
- Prior art keywords
- glycine
- phosphite
- reaction
- dialkylhydrogen
- alkanol
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 5
- XDDAORKBJWWYJS-UHFFFAOYSA-N glyphosate Chemical compound OC(=O)CNCP(O)(O)=O XDDAORKBJWWYJS-UHFFFAOYSA-N 0.000 title claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
- 239000004471 Glycine Substances 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical class OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 claims 4
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 3
- 229930040373 Paraformaldehyde Natural products 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229920002866 paraformaldehyde Polymers 0.000 claims 2
- WBTIFBJEYFLFFW-UHFFFAOYSA-N 2-(hydroxymethylazaniumyl)acetate Chemical compound OCNCC(O)=O WBTIFBJEYFLFFW-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- -1 alkyl hydrogen phosphite Chemical compound 0.000 claims 1
- 230000020335 dealkylation Effects 0.000 claims 1
- 238000006900 dealkylation reaction Methods 0.000 claims 1
- GBHRVZIGDIUCJB-UHFFFAOYSA-N hydrogenphosphite Chemical compound OP([O-])[O-] GBHRVZIGDIUCJB-UHFFFAOYSA-N 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
1종의 글리신을 출발원료로 하는 N-포스포노메틸 글리신의 제조에 있어서, 글리신과 파라포름알데히드를 트리에틸아민의 존재하, C1∼C2알칸올 중에서 반응시킨 반응물과 디알킬 하이드로겐 포스파이트 또는 일부가 모노 알킬 하이드로겐 포스파이트로 변화된 저순도 디알킬 하이드로겐 포스파이트의 어느 하나를 55℃ 이하의 온도에서 반응시키고, 선택적으로 N-(N-히드록시메틸)포스포노메틸글리신 알킬 에스테르만으로 한후, 50℃ 이하에서 HCl과 반응시켜 탈 메틸롤 및 부분적으로 탈 알킬화하고 pH 7.0~7.5에서 알칸올을 증류시켜 알킬랄을 함유하지 않는 알칸올을 수득하고 잔류물에 HCl을 가하여 환류 온도에서 탈알킬화를 완성한 후, 알칼리로 중화시킴을 특징으로 하는 N-포스포노메틸글리신을 제조하는 방법.
제 1 항에 있어서, 글리신과 파라포름알데히드와의 반응에서 얻어진 비스-N,N-히드록시메틸글리신과 디알킬하이드로겐 포스파이트 또는 모노알킬 하이드로겐 포스파이트를 함유하는 저순도 디알킬하이드로겐포스파이트와의 반응이 55℃ 이하, 바람직하기로는 50 내지 20℃에서 수행되는 방법.
제 1 항에 있어서, 디알킬하이드로겐포스파이트의 모노알킬하이드로겐포스파이트에 대한 변화의 고저에 관계없이 상기 제 2 항의 반응 조건으로 반응시키는 방법.
제 1 항에 있어서, 알칸올이 C1∼C2알코올인 방법.
제 1 항에 있어서, 알칸올의 사용이 글리신에 대하여 9∼15배인 방법.
제 1 내지 3항 중의 어느 하나에 있어서, 디알킬하이드로겐포스파이트가 하기식(I)로 표시되고, 모노알킬하이드로겐포스파이트가 하기식(II)로 표시되는 방법.
상기식에서 R은 C1∼C2의 알킬이다.
※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019880007187A KR900003411B1 (ko) | 1988-06-15 | 1988-06-15 | N-포스포노메틸 글리신의 제조방법 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019880007187A KR900003411B1 (ko) | 1988-06-15 | 1988-06-15 | N-포스포노메틸 글리신의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR900000374A true KR900000374A (ko) | 1990-01-30 |
| KR900003411B1 KR900003411B1 (ko) | 1990-05-18 |
Family
ID=19275213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880007187A KR900003411B1 (ko) | 1988-06-15 | 1988-06-15 | N-포스포노메틸 글리신의 제조방법 |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR900003411B1 (ko) |
-
1988
- 1988-06-15 KR KR1019880007187A patent/KR900003411B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR900003411B1 (ko) | 1990-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE1242T1 (de) | Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure. | |
| US4657705A (en) | Process for the preparation of N-substituted aminomethylphosphonic acids | |
| US2500022A (en) | Dialkyl alkoxy methane phosphonates and method of preparation | |
| US2865948A (en) | New phosphorylated heterocyclic compounds and processes for preparing same | |
| KR900016241A (ko) | 알킬아포스폰산 디에스테르 및/또는 디알킬아포스핀산 에스테르의 제조방법 | |
| KR840005158A (ko) | N-포스포노 메틸글리신의 제조방법 | |
| KR900000374A (ko) | N-포스포노메틸 글리신의 제조방법 | |
| US2875230A (en) | Preparation of neutral mixed phosphates from trialkyl phosphates and alcohols | |
| US2875229A (en) | Preparation of neutral mixed phosphates from trialkyl phosphates and carboxylic acid esters | |
| US3801680A (en) | O(s),s-dihydrocarbyl-n-acylphosphoroamidothio,dithoates | |
| HU213457B (en) | Process for producing aminomethanephosphonic acid and aminomethyl-phosphinic acid | |
| US3272892A (en) | Method of preparing organic phosphonates by transesterification | |
| Yamazaki et al. | Studies on reactions of the N-phosphonium salts of pyridines. XIX. Carbonylation of amines with carbon dioxide by means of phosphorus chlorides in tertiary amines. | |
| ATE67500T1 (de) | Verfahren zur herstellung von aminomethylenphosphonalkylphosphinaten. | |
| GB1353196A (en) | C1-c4 alkyl 2,3-dibromopropyl acid phosphates | |
| US3062858A (en) | Process for preparing partial esters of pyrophosphoric acid | |
| KR880011136A (ko) | 아졸- 아미노메틸렌 비스포스폰산 유도체 | |
| US4351779A (en) | Process for the production of methylaminomethylphosphonic acid esters | |
| US3354166A (en) | Nu-substituted ammonium salts of monoesterified phosphonic acids | |
| US2908709A (en) | Process for preparing phosphonates | |
| US2495799A (en) | Chloroalkyl phosphorous oxy and sulfodichlorides | |
| Michalski et al. | Organophosphorus compounds. Part CXXXVI. Thiopyrophosphate synthesis by condensation of oxophosphoranesulphenyl chlorides with trialkyl phosphites and their structural analogues | |
| Maier | ORGANIC PHOSPHORUS COMPOUNDS 1001 SYNTHESIS AND PROPERTIES OF N-HYDROXYCARBONYLMETHYL-AMINOMETHYL-DIALKYLPHOSPHINE OXIDES | |
| Terent'eva et al. | Reaction of 2-ethyl-4, 5-benzo-1, 3, 2-oxazaphospholane with mercaptans | |
| US3882201A (en) | Thiophosphoric acid triesters |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| G160 | Decision to publish patent application | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| LAPS | Lapse due to unpaid annual fee |