KR900000357A - Antiarrhythmics - Google Patents

Antiarrhythmics Download PDF

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Publication number
KR900000357A
KR900000357A KR1019880006666A KR880006666A KR900000357A KR 900000357 A KR900000357 A KR 900000357A KR 1019880006666 A KR1019880006666 A KR 1019880006666A KR 880006666 A KR880006666 A KR 880006666A KR 900000357 A KR900000357 A KR 900000357A
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KR
South Korea
Prior art keywords
compound
nhso
alkyl
pharmaceutically acceptable
salt
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Application number
KR1019880006666A
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Korean (ko)
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KR900006902B1 (en
Inventor
에드워드 크로스 피터
노엘 토마스 제프리
에드문드 아로우스미스 존
피터 디킨슨 로저
Original Assignee
알렌 제이.스피겔
화이자 인코포레이티드
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Priority to KR1019880006666A priority Critical patent/KR900006902B1/en
Publication of KR900000357A publication Critical patent/KR900000357A/en
Application granted granted Critical
Publication of KR900006902B1 publication Critical patent/KR900006902B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음No content

Description

항부정맥제Antiarrhythmics

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (11)

일반식(A)의 화합물 또는 그의 염.A compound of the general formula (A) or a salt thereof. 상기식에서 R은 -NHSO2(C1내지 C4알킬), -NH2또는 -NO2이고 ; R1은 C1내지 C4알킬이며 ; ″Het″는 그룹Wherein R is -NHSO 2 (C 1 -C 4 alkyl), -NH 2 or -NO 2 ; R 1 is C 1 to C 4 alkyl; "Het" is a group [여기에서, R2은 H, CH3또는 C2H5이고 ; R3는 -NHSO2(C1내지 C4알킬), -NH2또는 -NO2이며 ; X는 O, S 또는 NR4(여기에서, R4는 H 또는 CH3이다)이다]이며 ; 단, R 및 R3중 하나가 -NO2일 경우, 다른 하나는 -NH2가 아니다.Wherein R 2 is H, CH 3 or C 2 H 5 ; R 3 is -NHSO 2 (C 1 -C 4 alkyl), -NH 2 or -NO 2 ; X is O, S, or NR 4 is (wherein, R 4 is H or CH 3)], and; If, however, one of R and R 3 is -NO 2 days, the other is not -NH 2. 제1항에 있어서, R이 -NHSO2(C1내지 C4알킬)이고, R3가 -NHSO2(C1내지 C4알킬)인 화합물 또는 약제학적으로 허용되는 그의 염.The compound or a pharmaceutically acceptable salt thereof according to claim 1, wherein R is -NHSO 2 (C 1 to C 4 alkyl) and R 3 is -NHSO 2 (C 1 to C 4 alkyl). 제2항에 있어서, R이 -NHSO2CH3이고, R1이 CH3또는 C2H5이며, ″Het″가 그룹A compound according to claim 2, wherein R is -NHSO 2 CH 3 , R 1 is CH 3 or C 2 H 5 , and "Het" (여기에서, R2는 H 또는 CH3이고, X는 O 또는 S이며, ″Het″의 a 또는 b위치에 결합된 R3는 -NHSO2, CH3이다)인 화합물.(Wherein R 2 is H or CH 3 , X is O or S, and R 3 bonded to the a or b position of "Het" is -NHSO 2 , CH 3 ). 제3항에 있어서, 하기 구조식을 갖는 화합물 ;The compound according to claim 3, which has the following structural formula: 제2항 내지 제4항중 어느 한 항에 청구된 화합물 또는 약제학적으로 허용되는 그의 염 및 약제학적으로 허용되는 희석제 또는 담체를 함유하는 약제학적 조성물.A pharmaceutical composition comprising a compound as claimed in any one of claims 2 to 4 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier. 제2항 내지 제4항중 어느 한 항에 있어서, 약제로서 사용하기 위한 화합물 또는 약제학적으로 허용되는 그의 염.5. A compound according to any one of claims 2 to 4 for use as a medicament, or a pharmaceutically acceptable salt thereof. 심부정맥의 예방 또는 완화에 사용되는 약제의 제조를 위한, 제2항 내지 제4항중 어느 한 항에서 청구된 화합물 또는 약제학적으로 허용되는 그의 염의 용도.Use of a compound as claimed in any one of claims 2 to 4 or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prevention or alleviation of cardiac arrhythmia. 제1항에 있어서, 명세서에서 특정하게 언급한 것중의 하나인 일반식(A)의 화합물 또는 그의 염.A compound according to claim 1, which is one of the specifically mentioned in the description, or a salt thereof. 특히 실시예 및 제조실시예와 관련하여, 본질적으로 본 명세서에 기술된 바와 같은 제1항에서 정의된 일반식(A)의 화합물 또는 그의 염을 제조하는 방법.In particular with regard to the examples and preparative examples, a process for the preparation of a compound of formula (A), or salts thereof, as defined in claim 1, essentially as described herein. 제1항에 있어서, 제9항에서 청구된 방법에 의해 제조된 일반식(A)의 화합물 또는 그의 염.The compound of the general formula (A) or a salt thereof according to claim 1, which is produced by the method as claimed in claim 9. 제5항에 있어서, 본질적으로 본 명세서에 기술된 바와 같은 약제학적 조성물.6. The pharmaceutical composition according to claim 5, essentially as described herein. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019880006666A 1988-06-03 1988-06-03 Antiarrhythmic agents KR900006902B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019880006666A KR900006902B1 (en) 1988-06-03 1988-06-03 Antiarrhythmic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019880006666A KR900006902B1 (en) 1988-06-03 1988-06-03 Antiarrhythmic agents

Publications (2)

Publication Number Publication Date
KR900000357A true KR900000357A (en) 1990-01-30
KR900006902B1 KR900006902B1 (en) 1990-09-24

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ID=19274928

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880006666A KR900006902B1 (en) 1988-06-03 1988-06-03 Antiarrhythmic agents

Country Status (1)

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KR (1) KR900006902B1 (en)

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Publication number Publication date
KR900006902B1 (en) 1990-09-24

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