KR890701139A - Tc-99m 방사성의약품의 제조 - Google Patents
Tc-99m 방사성의약품의 제조Info
- Publication number
- KR890701139A KR890701139A KR1019890700039A KR890700039A KR890701139A KR 890701139 A KR890701139 A KR 890701139A KR 1019890700039 A KR1019890700039 A KR 1019890700039A KR 890700039 A KR890700039 A KR 890700039A KR 890701139 A KR890701139 A KR 890701139A
- Authority
- KR
- South Korea
- Prior art keywords
- complex
- ligand
- halide
- general formula
- tco
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000012217 radiopharmaceutical Substances 0.000 title claims 2
- 229940121896 radiopharmaceutical Drugs 0.000 title claims 2
- 230000002799 radiopharmaceutical effect Effects 0.000 title claims 2
- 239000003446 ligand Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 6
- 125000002577 pseudohalo group Chemical group 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 4
- 150000002443 hydroxylamines Chemical class 0.000 claims 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- CUJRVFIICFDLGR-UHFFFAOYSA-N acetylacetonate Chemical compound CC(=O)[CH-]C(C)=O CUJRVFIICFDLGR-UHFFFAOYSA-N 0.000 claims 2
- 150000001450 anions Chemical class 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- 229910052713 technetium Inorganic materials 0.000 claims 2
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 claims 2
- -1 1, 5-phenylene Chemical group 0.000 claims 1
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 claims 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims 1
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 150000004985 diamines Chemical class 0.000 claims 1
- TZMFJUDUGYTVRY-UHFFFAOYSA-N ethyl methyl diketone Natural products CCC(=O)C(C)=O TZMFJUDUGYTVRY-UHFFFAOYSA-N 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 150000002527 isonitriles Chemical class 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Developing Agents For Electrophotography (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8711496 | 1987-05-15 | ||
| GB878711496A GB8711496D0 (en) | 1987-05-15 | 1987-05-15 | Tc-99m radiopharmaceuticals |
| PCT/GB1988/000383 WO1988008720A1 (en) | 1987-05-15 | 1988-05-16 | Preparation of tc-99m radiopharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890701139A true KR890701139A (ko) | 1989-12-19 |
Family
ID=10617388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019890700039A Withdrawn KR890701139A (ko) | 1987-05-15 | 1988-05-16 | Tc-99m 방사성의약품의 제조 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5081232A (enExample) |
| EP (1) | EP0291281B1 (enExample) |
| JP (1) | JPS6452787A (enExample) |
| KR (1) | KR890701139A (enExample) |
| AT (1) | ATE65917T1 (enExample) |
| AU (1) | AU603443B2 (enExample) |
| CA (1) | CA1323484C (enExample) |
| DE (1) | DE3864071D1 (enExample) |
| ES (1) | ES2039279T3 (enExample) |
| GB (1) | GB8711496D0 (enExample) |
| IL (1) | IL86388A0 (enExample) |
| WO (1) | WO1988008720A1 (enExample) |
| ZA (1) | ZA883451B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001979A (en) * | 1989-08-29 | 1999-12-14 | Nycomed Amersham Plc | Cores for technetium radiopharmaceuticals |
| US5744120A (en) * | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
| US5961952A (en) * | 1996-01-24 | 1999-10-05 | Dupont Pharmaceuticals Company | 99m Tc-tertiary-butyl isonitrile as breast tumor imaging agents |
| GR1003191B (el) * | 1998-01-13 | 1999-10-29 | ������ ������ ������� ������� ��������� ����������.... | Μεθοδος, συνθεση προσκευασματος (κιτ) και προσκευασμα (κιτ) για τη παρασκευη σε ενα σταδιο του συμπλοκου τεχνητιο 99μ (v) διμερκαπτοηλεκτρικο οξυ, για τη διαγνωση του μυελοειδους καρκινωματος του θυρεοειδους καθως και διαφορων ογκων |
| JP2025527225A (ja) * | 2022-07-29 | 2025-08-20 | キュリウム ユーエス エルエルシー | ［１７７ｌｕ］ルテチウム－ｐｓｍａ ｉ＆ｔ組成物、キット、それを作製する方法、及びそれを使用する方法 |
| WO2025029946A1 (en) | 2023-07-31 | 2025-02-06 | Curium Us Llc | [177lu] lutetium-psma i&t composition and dosimetry, kit, method of making, and method of using thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4387087A (en) * | 1980-04-18 | 1983-06-07 | Research Corporation | Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging |
| US4489054A (en) * | 1980-04-18 | 1984-12-18 | Research Corporation | Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging |
| US4451450A (en) * | 1981-10-15 | 1984-05-29 | New England Nuclear Corporation | Cationic compounds useful for making radiodiagnostic agents |
| US4374821A (en) * | 1982-06-28 | 1983-02-22 | E. R. Squibb & Sons, Inc. | Myocardial imaging agent and method |
| US4481184A (en) * | 1983-02-14 | 1984-11-06 | E. R. Squibb & Sons, Inc. | Cationic technetium (I) complexes |
| US4526776A (en) * | 1983-04-15 | 1985-07-02 | E. I. Du Pont De Nemours & Company | Cationic cyanato and thiocyanato complexes useful as radiodiagnostic agents |
| US4851515A (en) * | 1983-12-29 | 1989-07-25 | The Commonwealth Of Australia | Preparation of 99m Tc radiopharmaceuticals |
| US4707544A (en) * | 1984-11-28 | 1987-11-17 | President And Fellows Of Harvard College | Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents |
-
1987
- 1987-05-15 GB GB878711496A patent/GB8711496D0/en active Pending
-
1988
- 1988-05-11 ES ES198888304239T patent/ES2039279T3/es not_active Expired - Lifetime
- 1988-05-11 DE DE8888304239T patent/DE3864071D1/de not_active Expired - Lifetime
- 1988-05-11 AT AT88304239T patent/ATE65917T1/de not_active IP Right Cessation
- 1988-05-11 EP EP88304239A patent/EP0291281B1/en not_active Expired - Lifetime
- 1988-05-13 AU AU16152/88A patent/AU603443B2/en not_active Expired
- 1988-05-13 CA CA000566779A patent/CA1323484C/en not_active Expired - Fee Related
- 1988-05-15 IL IL86388A patent/IL86388A0/xx unknown
- 1988-05-16 WO PCT/GB1988/000383 patent/WO1988008720A1/en not_active Ceased
- 1988-05-16 JP JP63119055A patent/JPS6452787A/ja active Granted
- 1988-05-16 KR KR1019890700039A patent/KR890701139A/ko not_active Withdrawn
- 1988-05-16 US US07/194,285 patent/US5081232A/en not_active Expired - Lifetime
- 1988-05-16 ZA ZA883451A patent/ZA883451B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5081232A (en) | 1992-01-14 |
| GB8711496D0 (en) | 1987-06-17 |
| JPS6452787A (en) | 1989-02-28 |
| ES2039279T3 (es) | 1993-09-16 |
| EP0291281A1 (en) | 1988-11-17 |
| AU1615288A (en) | 1988-11-17 |
| AU603443B2 (en) | 1990-11-15 |
| WO1988008720A1 (en) | 1988-11-17 |
| ZA883451B (en) | 1989-01-25 |
| JPH0576953B2 (enExample) | 1993-10-25 |
| CA1323484C (en) | 1993-10-26 |
| EP0291281B1 (en) | 1991-08-07 |
| ATE65917T1 (de) | 1991-08-15 |
| DE3864071D1 (de) | 1991-09-12 |
| IL86388A0 (en) | 1988-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19890111 |
|
| PG1501 | Laying open of application | ||
| PC1202 | Submission of document of withdrawal before decision of registration |
Comment text: [Withdrawal of Procedure relating to Patent, etc.] Withdrawal (Abandonment) Patent event code: PC12021R01D Patent event date: 19921019 |
|
| WITB | Written withdrawal of application |