KR890016033A - Method for preparing furan derivative - Google Patents

Method for preparing furan derivative Download PDF

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Publication number
KR890016033A
KR890016033A KR1019890005430A KR890005430A KR890016033A KR 890016033 A KR890016033 A KR 890016033A KR 1019890005430 A KR1019890005430 A KR 1019890005430A KR 890005430 A KR890005430 A KR 890005430A KR 890016033 A KR890016033 A KR 890016033A
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KR
South Korea
Prior art keywords
methyl
solvent
ranitidine
represented
following structural
Prior art date
Application number
KR1019890005430A
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Korean (ko)
Inventor
레슬리 크루케스 데렉
Original Assignee
원본미기재
글락소 그룹 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 원본미기재, 글락소 그룹 리미티드 filed Critical 원본미기재
Publication of KR890016033A publication Critical patent/KR890016033A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

푸란 유도체의 제조 방법Method for preparing furan derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (8)

아래 구조식(VI)로 나타내는 2-[[[5-(디메틸아미노)메틸-2-푸란일]메틸]티오]에탄아민을 아래 구조식(VII)로 나타내는 1-알콕시-N-메틸-2-니트로에텐아민과 반응시키는것을 특징으로 하는 아래 구조식(I)로 나타내는 라니티딘의 제조 방법.1-alkoxy-N-methyl-2-nitro represented by the following structural formula (VII) to 2-[[[5- (dimethylamino) methyl-2-furanyl] methyl] thio] ethanamine represented by the following structural formula (VI) A process for producing ranitidine represented by the following structural formula (I), characterized by reacting with ethene amine. 위 식에서 L은 C1-4알콕시기이다.Where L is a C 1-4 alkoxy group. 제 1 항에 있어서, 라니티딘이 후속 단계에서 산부가염으로 전환되는 방법.The method of claim 1, wherein ranitidine is converted to an acid addition salt in a subsequent step. 제 1 항에 있어서, 라니티딘이 후속 단계에서 염화수소염으로 전환되는 방법.The method of claim 1, wherein ranitidine is converted to hydrogen chloride in a subsequent step. 제 1 항 내지 제 3 항 중 어느 하나의 항에 있어서, L이 에톡시인 방법.The method of claim 1, wherein L is ethoxy. 제 1 항 내지 제 4 항 중, 어느 하나의 항에 있어서, 반응이 용매 중에서 진행되는 방법.The process according to any of claims 1 to 4, wherein the reaction proceeds in a solvent. 제 5 항에 있어서, 용매가 물, 알콜 또는 이들의 혼합물인 방법.The method of claim 5 wherein the solvent is water, alcohols or mixtures thereof. 제 1 항 내지 제 4 항 중 어느 하나의 항에 있어서, 반응물질이 용매 부재하에 가열되는 방법.The method of claim 1, wherein the reactant is heated in the absence of a solvent. 제 1 항 내지 제 7 항 중 어느 하나의 항에 있어서,구조식(VI)의 아민이 유리 염기 또는 유기산염이나 무기산염의 형태로 사용되는 방법.8. The process according to claim 1, wherein the amine of formula VI is used in the form of a free base or an organic acid salt or an inorganic acid salt. 9. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890005430A 1988-04-26 1989-04-25 Method for preparing furan derivative KR890016033A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888809836A GB8809836D0 (en) 1988-04-26 1988-04-26 Chemical process
GB8809836 1988-04-26

Publications (1)

Publication Number Publication Date
KR890016033A true KR890016033A (en) 1989-11-28

Family

ID=10635860

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890005430A KR890016033A (en) 1988-04-26 1989-04-25 Method for preparing furan derivative

Country Status (6)

Country Link
JP (1) JPH0256476A (en)
KR (1) KR890016033A (en)
DK (1) DK200589A (en)
FI (1) FI891950A (en)
GB (2) GB8809836D0 (en)
IT (1) IT1231461B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2411401B (en) * 2002-12-27 2006-11-22 Council Scient Ind Res Process for production of alkanesulfonic acid

Also Published As

Publication number Publication date
IT8947880A0 (en) 1989-04-24
GB2217713A (en) 1989-11-01
FI891950A0 (en) 1989-04-25
DK200589D0 (en) 1989-04-25
GB2217713B (en) 1991-08-14
GB8909397D0 (en) 1989-06-14
IT1231461B (en) 1991-12-07
FI891950A (en) 1989-10-27
JPH0256476A (en) 1990-02-26
GB8809836D0 (en) 1988-06-02
DK200589A (en) 1989-10-27

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