KR890012670A - Antiviral formulation - Google Patents

Antiviral formulation Download PDF

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KR890012670A
KR890012670A KR1019890001620A KR890001620A KR890012670A KR 890012670 A KR890012670 A KR 890012670A KR 1019890001620 A KR1019890001620 A KR 1019890001620A KR 890001620 A KR890001620 A KR 890001620A KR 890012670 A KR890012670 A KR 890012670A
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interferon
component
hybrid
alanyl
acetyl
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KR1019890001620A
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Korean (ko)
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KR0131077B1 (en
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강게미 제이.데이비드
호크켑펠 하인쯔-쿠르트
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에른스트 알테르
시비-가이기 에이지
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Described is a synergistic pharmaceutical combination preparation comprising as component A a hybrid alpha -interferon the structure of which is derived from human interferon- alpha -D and - alpha -B gene fragments and as component B a muramylpeptide. Said preparation can be used for treating viral diseases or reducing the formation of metastases of certain tumors.

Description

항바이러스 배합물Antiviral formulation

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (11)

성분 A로서 구조가 인간 인터페론-α-D 및 -α-B 유전자단편으로부터 유도된 잡종 인터페론 및 성분 B로서 하나이상의 염-형성 그룹을 갖는 뮤라밀 팹티드 또는 뮤라밀팹티드의 약제학적으로 허용되는 염을 약제학적으로 허용되는 담체와 함께 함유하는 약제학적 배합제제.A hybrid interferon whose structure as component A is derived from human interferon-α-D and -α-B gene fragments, and a muramyl peptide or muramyl peptide with muramyl peptides having at least one salt-forming group as component B A pharmaceutical formulation containing the compound together with a pharmaceutically acceptable carrier. 제1항에 있어서, 성분 A가 총 166개의 아미노산을 갖는 잡종 α-인터페론이고 인간의 림프아세포 또는 백혈구 인터페론 α-B 또는 -α-D의 아미노산 서열과 아미노산의 조성 및 수가 상응하는 4개의 서열, 즉 인터페론-α-B의 아미노산 1-60, 인터페론 -α-B 또는 -α-D의 아미노산 61-92, 인터페론-α-B 또는 -α-D의 아미노산 93-150 및 인터페론 α-B의 또는 -α-D의 아미노산 151-166로 구성되며 각 잡종은 인터페론 -α-B 및 인터페론-α-D의 서열 중 허느 하나를 하나이상 갖는 제제.4. The sequence of claim 1, wherein component A is a hybrid α-interferon having a total of 166 amino acids and four sequences corresponding to the composition and number of amino acids in the amino acid sequence of human lymphoblast or leukocyte interferon α-B or -α-D, Ie amino acids 1-60 of interferon-α-B, amino acids 61-92 of interferon-α-B or -α-D, amino acids 93-150 of interferon-α-B or -α-D and interferon α-B or An agent consisting of amino acids 151-166 of -α-D, wherein each hybrid has at least one of the sequences of interferon-α-B and interferon-α-D. 제1항 또는 제2항에 있어서, 성분 A가 B₁B₂B₃D₄, B₁B₂D₃B₄, B₁B₂D₃D₄, B₁D₂B₃D₄, B₁D₂D₃B₄, B₁D₂D₃D₄, 및 B₁D₂B₃B9D선택된 잡종 α-인터페론 폴리펩티드인 제제.The formulation according to claim 1 or 2, wherein component A is B₁B₂B₃D₄, B₁B₂D₃B₄, B₁B₂D₃D₄, B₁D₂B₃D₄, B₁D₂D₃B₄, B₁D₂D₃D₄, and B₁D₂B₃B 9D selected hybrid α-interferon polypeptides. 제1항 내지 제3항 중 어느 한 항에 있어서, 성분 B가 N-아세틸-뮤라밀-L-알라닐-D-이소글루타민, N-아세틸-뮤라밀-L-트레오닐-D-이소글루타민, N-아세틸-데메틸류라밀-L-알라닐-D-이소글루타민 또는 N-아세틸-뮤라밀-L-알라닐-D-이소글루타미닐-L-알라닐-2-(1,2-디팔리토일-Sn-글리세로-3-하이드로시포스포릴옥시)-에틸-아미드 및 이의 약제학적으로 허용되는 염인 제제.The component B according to any one of claims 1 to 3, wherein component B is N-acetyl-muramil-L-alanyl-D-isoglutamine, N-acetyl-muramil-L-threonyl-D-isoglutamine. , N-acetyl-demethylleuramid-L-alanyl-D-isoglutamine or N-acetyl-muramil-L-alanyl-D-isoglutaminyl-L-alanyl-2- (1,2 A formulation which is dipalitoyl-Sn-glycero-3-hydrocyphosphoryloxy) -ethyl-amide and pharmaceutically acceptable salts thereof. 제1항 내지 제4항 중 어느 한 항에 있어서, 성분 A가 잡종 α-인터페론 폴리펩티드 B₁D₂B₃B₄인 제제.The formulation according to claim 1, wherein component A is a hybrid α-interferon polypeptide B₁D₂B₃B₄. 제1항 내지 제5항 중 어느 한 항에 있어서, 성분 B가 N-아세틸-뮤라밀-L-알라닐-이소글루타미닐-L-알라민-2-(1,2-디팔미토일-Sn-글리세로-3-하이드록시포스포릴옥시)-에틸아미드의 약제학적으로 허용되는 염인 제제.The component B according to any one of claims 1 to 5, wherein the component B is N-acetyl-muramil-L-alanyl-isoglutaminyl-L-alanine-2- (1,2-dipalmitoyl- A formulation which is a pharmaceutically acceptable salt of Sn-glycero-3-hydroxyphosphoryloxy) -ethylamide. 제1항에 있어서, 성분 A로서 잡종 α-인터페론 폴리펩티드 B1D2B3B4와 성분 B로서 N-아세틸-뮤라밀-L-알라닐-D-이소글루타미닐-L-알라닐-2-(1,2-디팔미토일-Sn-글리세로-3-하이드록시포스포릴옥시)-에틸아미드의 약제학적으로 허용되는 염과의 배합물(여기에서 B 대 A의 중량비는 1/1 내지 100/1이다)을 항바이러스 유효량 및 대식세포 활성량으로 함유하는, 온혈동물의 바이러스에 의한 감염치료용 또는 대식세포의 활성화용 제제.The method of claim 1, wherein the hybrid α-interferon polypeptide B 1 D 2 B 3 B 4 as component A and N-acetyl-muramil-L-alanyl-D-isoglutaminyl-L-alanyl- as component B Combination of 2- (1,2-dipalmitoyl-Sn-glycero-3-hydroxyphosphoryloxy) -ethylamide with a pharmaceutically acceptable salt, wherein the weight ratio of B to A is from 1/1 to 100/1) in an antiviral effective amount and macrophage active amount. 제1항 내지 제6항 중 어느 한 항에 있어서, B 대 A의 중량비가 1/1 내지 100/1인 제제.The formulation according to any one of claims 1 to 6, wherein the weight ratio of B to A is 1/1 to 100/1. 제1항 내지 제8항중 어느 한 항에 있어서, 약제학적으로 허용되는 담체가 합성 포스파티딜콜린 및 합성 포르파티딜 세린의 약제학적으로 허용되는 염으로부터 제조된 리포좀을 함유하는 제제.The formulation according to claim 1, wherein the pharmaceutically acceptable carrier contains liposomes prepared from pharmaceutically acceptable salts of synthetic phosphatidylcholine and synthetic poratidylserine. 성분 A로서 구조가 인간 인터페론-α-D 및 α-B유전자 단편으로부터 유도된 잡종 α-인터페론과 성분 B로서 뮤라밀 팹티드를 항 바이러스 유효량 또는 전이형성 억제량으로 B 대 A의 중량비가 0.4/1 내지 400/1이 되도록 온혈동물에게 투여함을 특징으로 하여, 바이러스 또는 종양으로 인한 질환으로 고통받는 인간을 포함하는 온혈동물을 치료하는 방법.Hybrid A-interferon derived from human interferon-α-D and α-B gene fragments as component A and muramyl peptides as component B in an antiviral effective amount or inhibitory metastasis ratio of 0.4 / A weight ratio 0.4 / A A method for treating a warm blooded animal comprising a human suffering from a disease caused by a virus or a tumor, characterized by administering to the warm blooded animal so as to be 1 to 400/1. 제10항에 있어서, 성분 A로서 잡종 α-인터페론 폴리팹티드 B1D2B3B4와 성분 B로서 N-아세틸-뮤라밀-L-알라닐-D-이소글루타미닐-L-알라닌-2-(1,2-디팔미토일-Sn-글리세로-3-하이드록시포스포릴옥시)-에틸-아미드와의 배합물(여기에서 B 대 A의 중량비는 1/1 내지 100/1이다)을 대식세포 활성량 또는 항바이러스 유효량으로 온혈동물에게 투여함을 특징으로 하여, 온혈동물의 대식세포를 활성화시키거나 헤르페스비리데(Herpesviridae)로 인한 감염을 치료하는 방법.11. The method of claim 10, wherein the hybrid α-interferon polypeptide B 1 D 2 B 3 B 4 as component A and N-acetyl-muramil-L-alanyl-D-isoglutaminyl-L-alanine as component B Combination with 2- (1,2-dipalmitoyl-Sn-glycero-3-hydroxyphosphoryloxy) -ethyl-amide, wherein the weight ratio of B to A is 1/1 to 100/1 A method for activating a macrophage of a warm-blooded animal or treating an infection caused by Herpesviridae, characterized by administering to a warm-blooded animal in a macrophage active amount or an antiviral effective amount. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890001620A 1988-02-13 1989-02-13 Antiviral combination KR0131077B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8803365 1988-02-13
CH8803365 1988-02-13
GB888803365A GB8803365D0 (en) 1988-02-13 1988-02-13 Antiviral combination

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KR890012670A true KR890012670A (en) 1989-09-18
KR0131077B1 KR0131077B1 (en) 1998-04-17

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US (1) US5137720A (en)
EP (1) EP0329609B1 (en)
JP (1) JP2781191B2 (en)
KR (1) KR0131077B1 (en)
AT (1) ATE99953T1 (en)
AU (1) AU623876B2 (en)
CA (1) CA1336578C (en)
DE (1) DE68912155T2 (en)
DK (1) DK62089A (en)
GB (1) GB8803365D0 (en)
IE (1) IE63493B1 (en)
IL (1) IL89248A (en)
NZ (1) NZ227944A (en)
PH (1) PH26919A (en)
ZA (1) ZA891053B (en)

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TW218846B (en) * 1992-04-07 1994-01-11 Ciba Geigy
FR2702659B1 (en) * 1993-03-19 1995-08-25 Vacsyn Sa Compositions for application in human therapy, characterized by the association of a muramyl-peptide with a cytokine.
DK0689449T3 (en) * 1993-03-19 2003-03-03 Vacsyn Sa Preparations for use in human therapy, characterized by combining a muramyl peptide with a cytokine
US5461512A (en) * 1993-11-30 1995-10-24 Eastman Kodak Company Zoom camera lens having three moving groups
DK0708085T3 (en) * 1994-10-19 2002-11-11 Novartis Ag Antiviral ethers of aspartate protease substrate isosters
US5786214A (en) * 1994-12-15 1998-07-28 Spinal Cord Society pH-sensitive immunoliposomes and method of gene delivery to the mammalian central nervous system
CZ304942B6 (en) 2000-03-31 2015-02-04 Purdue Research Foundation Medicament for increasing specific elimination of tumor cell population and pharmaceutical composition containing phosphate-FITC conjugate or phosphate-dinitrophenyl
CA2461877A1 (en) * 2001-09-28 2003-04-10 Purdue Research Foundation Method of treatment using ligand-immunogen conjugates
US20030180348A1 (en) * 2002-03-22 2003-09-25 Levinson R. Saul Transcellular drug delivery system
WO2007092299A2 (en) * 2006-02-03 2007-08-16 Purdue Research Foundation Targeted conjugates and radiation
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
US20080317836A1 (en) * 2007-06-19 2008-12-25 Discovery Partners Llc Topical compositions for anti-aging skin treatment
RU2488405C1 (en) * 2012-07-17 2013-07-27 Илья Александрович Марков Drug herpferon-2 possessing antiviral, anti-inflammatory, immunomodulatory and analgesic action for local and external application
KR101658048B1 (en) 2014-06-25 2016-09-20 한국생명공학연구원 Anti-viral composition comprising compounds related to phosphatidylcholine synthetic pathway

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JPS616000A (en) * 1984-06-21 1986-01-11 木下　菊巳 Rotary color matching disk
ATE78262T1 (en) * 1985-06-11 1992-08-15 Ciba Geigy Ag HYBRID INTERFERONS.
US4774085A (en) * 1985-07-09 1988-09-27 501 Board of Regents, Univ. of Texas Pharmaceutical administration systems containing a mixture of immunomodulators
AU603820B2 (en) * 1986-08-13 1990-11-29 Takeda Chemical Industries Ltd. Antitumor agent

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EP0329609A2 (en) 1989-08-23
IE890435L (en) 1989-08-13
DE68912155T2 (en) 1994-06-16
KR0131077B1 (en) 1998-04-17
DK62089A (en) 1989-08-14
EP0329609B1 (en) 1994-01-12
CA1336578C (en) 1995-08-08
NZ227944A (en) 1991-08-27
PH26919A (en) 1992-12-03
ZA891053B (en) 1989-10-25
EP0329609A3 (en) 1990-05-16
GB8803365D0 (en) 1988-03-16
IL89248A (en) 1994-01-25
JPH021410A (en) 1990-01-05
AU2894389A (en) 1989-08-17
ATE99953T1 (en) 1994-01-15
IE63493B1 (en) 1995-05-03
JP2781191B2 (en) 1998-07-30
DK62089D0 (en) 1989-02-10
US5137720A (en) 1992-08-11
AU623876B2 (en) 1992-05-28
IL89248A0 (en) 1989-09-10
DE68912155D1 (en) 1994-02-24

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