KR890009976A - Synthetic peptides, compositions comprising them and methods of inducing immunity using the compositions - Google Patents

Abstract

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Description

Synthetic peptides, compositions comprising them and methods of inducing immunity using the compositions.

Since this is a trivial issue, I did not include the contents of the text.

Claims (36)

Compounds of the formula Wherein n is an integer from 1 to about 10. The polymer compound Where n is an integer from 1 to about 10 and x is an integer from 2 to about 50. A composition for immunization against malaria induced by a tropical thermophilic malarial protozoa comprising the compound of claim 2 as an active ingredient in an excipient suitable for human application. 4. The composition of claim 3, wherein the excipient is suitable for parenteral administration to humans. A method of inducing protective immunity against malaria induced by a tropical febrile malarial protozoa, comprising administering the composition of claim 3 as much as an immunity-induced effective amount. 6. The method of claim 5, wherein the composition is administered by injection. The compound according to claim 2, wherein x is 30. 3. The compound according to claim 2, wherein n is 3. The composition of claim 3, wherein x is 30. 4. The composition of claim 3 wherein n is 3. 6. The method of claim 5, wherein x is 30. 6. The method of claim 5, wherein n is 3. 5. The composition of claim 4, wherein the excipient is aluminum hydroxide. 7. The process of claim 6, wherein the excipient is aluminum hydroxide. Compounds of the formula 15. An immunological composition against malaria caused by a tropical thermophilic malarial protozoa comprising the micro-complex of claim 15 as an active ingredient in an excipient suitable for parenteral administration. 17. A method of inducing protective immunity against malaria induced by a tropical fever malaria protozoa comprising administering an amount of the composition immunity-induced effect of claim 16. A compound of formula Tyr-Gly-Gly-Pro-Ala-Asn-Lys-Lys-Asn-Ala-Gly-OH. The compounds of the formula Asp-Glu-Leu-Glu- Ala-Glu-Thr-Gln-Asn-Val-Tyr-Ala-Ala-NH 2. The compounds of the formula Tyr-Ser-Leu-Phe- Gln-Lys-Glu-Lys-Met-Val-Leu-NH 2. A compound of the formula Lys-Leu-Tyr-Gln-Ala-Gln-Tyr-Asp-Leu-Ser-Ile-OH. Lys-Phe-Thr-Lys-Asp-Glu-Asn-Lys-Pro-Asp-Glu-OH. A composition for waxy use against malaria induced by a tropical thermophilic malarial protozoa comprising a mixture of a compound of the following formula (I) and (II) or the like in an excipient suitable for parenteral administration. (I) Tyr-Gly-Gly-Pro-Ala-Asn-Lys-Lys-Asn-Ala-Gly-OH, (II) Asp-Glu-Leu-Glu-Ala-Glu- _{-Tyr-Ala-Ala-NH 2} . 24. The composition of claim 23, wherein the composition comprises a peptide compound selected from the group consisting of the following formula (III) - (V). (Ⅲ) Tyr-Ser-Leu -Phe-Gln-Lys-Glu-Lys-Met-Val-Leu-NH 2, (Ⅳ) Lys-Leu-Tyr-Gln-Ala-Gln-Tyr-Asp- (Ⅲ) Tyr-Ser-Leu-Phe- Gln-Lys-Glu-Lys-Met-Val-Leu-NH 2 (ⅳ) Lys-Leu-Tyr-Gln-Ala-Gln-Tyr-Asp-Leu-Ser-Ile-OH (V) Lys-Lys-Phe-Thr-Lys-Asp-Glu-Asn-Lys-Pro-Asp-Glu-OH. 25. The composition of claim 24, wherein the peptide compound is a compound of formula III: (Ⅲ) Tyr-Ser-Leu -Phe-Gln-Lys-Glu-Lys-Met-Val-Leu-NH 2. 24. The composition of claim 23, wherein the dosage form is a standard saline solution. 24. The composition of claim 23, wherein the bulk is squalene. 24. The composition of claim 23, wherein the compound of formula I and II is bound to bovine serum albumin in a weight-to-weight ratio by glutaraldehyde. 24. The composition of claim 23, wherein the compounds of formula I and II are linked by copolymerization. 26. The composition of claim 25, wherein the compounds of Formulas I, II, and III are bound to bovine serum albumin on a weight-to-weight basis by glutaraldehyde. 26. The composition of claim 25, wherein the compounds of Formulas I, II, and III are bound by copolymerization. 26. The composition of claim 25, wherein the weight-to-weight ratio of the compound of formula I to the compound of formula II to the compound of formula III is from about 1: 1: 1 to about 10:10:10. 33. The composition of claim 32, wherein the weight to weight ratio is 1: 1: 1. 26. A method of inducing protective immunity against malaria induced by a tropical febrile malarial protozoa comprising injecting a composition of claim 25 in an amount of an immunity-inducing effect to a human. A method of inducing protective immunity against malaria induced by a tropical febrile malarial protozoa comprising injecting a human with an immunity-induced effective amount of the composition of claim 30. 31. A method of inducing protective immunity against malaria induced by a tropical febrile malarial protozoa comprising injecting the human with an immunity-induced effective amount of the composition of claim 31. ※ Note: It is disclosed by the contents of the first application.