KR890009861A - 킬레이트 형성 화합물 및 그의 용도 - Google Patents

킬레이트 형성 화합물 및 그의 용도 Download PDF

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Publication number
KR890009861A
KR890009861A KR1019880017852A KR880017852A KR890009861A KR 890009861 A KR890009861 A KR 890009861A KR 1019880017852 A KR1019880017852 A KR 1019880017852A KR 880017852 A KR880017852 A KR 880017852A KR 890009861 A KR890009861 A KR 890009861A
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South Korea
Prior art keywords
alkyl
alkylamino
nitrogen
compound
containing organic
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KR1019880017852A
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English (en)
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히로히꼬 야마우찌
준 다까하시
사까에 오까노
시게미 세리
마꼬또 아즈마
Original Assignee
도끼 가쓰유끼
니홍메디피직스 가부시끼가이샤
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Publication of KR890009861A publication Critical patent/KR890009861A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage

Abstract

내용 없음

Description

킬레이트 형성 화합물 및 그의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기 일반식(Ⅰ)의 폴리아민디티올 화합물.
    (상기식 중, R1,R2,R11및 R12는 각각 저급알킬기이고, R21는 수수원자 또는 저급알킬기이며, R3및 R13은 각각 수소원자 또는 질소-함유 유기기이고, 단 R3및 R13중 적어도 하나는 질소 함유 유기기이다.)
  2. 제1항에 있어서, R1,R2,R11및 R12가 각각 메틸 또는 에틸인 화합물.
  3. 제1 또는 2항에 있어서, R21이 에틸 또는 부틸인 화합물.
  4. 제1~3항중 어느 한 항에 있어서, 질소 함유 유기기가 일반식-A-N(R4)-R5[식중, A는 저급알킬렌이고, R4및 R5는 각각 수소, 저급알킬, 시클로(저급)알킬 또는 일반식-A'-N(R6)-R7(식중, A'는 저급알킬렌이고, R6및 R7은 각각 수소, 저급알킬 또는 시클로(저급)알킬이거나, R6및 R7은 인접 질소원자와 함께 치환 또는 비치환 5~8원 질소 함유 포화헤테로고리기를 형성한다.)의 기를 나타내거나, R4및 R5는 인접 질소원자와 함께 치환 또는 비치환 5~8원 질소 함유 포화헤테로고리기는 형성한다]의 기인 화합물.
  5. 제1~4항중 어느 한 항에 있어서, 질소-함유 유기기가 아미노 (저급)알킬, 저급알킬아미노 (저급)알킬, 디 (저급)알킬아미노 (저급)알킬, 피페리디노 (저급)알킬, 피페라지노 (저급)알킬, 피롤리디노 (저급)알킬, 4-저급알킬피페라지노(저급)알킬, 4-저급알킬피페리디노 (저급)알킬, 4-페닐 (저급)알킬피페라지노(저급)알킬, 4-페닐피레리디노 (저급)알킬, 모르폴리노, (저급)알킬, 저급알킬아미노 (저급)알킬아미노 (저급)알킬, 디 (저급)알킬아미노 (저급)알킬아미노 (저급)알킬, 피페리디노 (저급)알킬아미노 (저급)알킬, 피페라지노 (저급)알킬아미노 (저급)알킬, 4-저급알킬피페라지노 (저급)알킬아미노 (저급)알킬, 4-페닐 (저급)알킬피페라지노 (저급)알킬아미노 (저급)알킬, 시클로 (저급)알킬아미노 (저급)알킬 또는 모르폴리노 (저급)알킬아미노 (저급)알킬인 화합물.
  6. 제1~5항중 어느 한 항에 있어서, 질소-함유 유기기가 아미노메틸, 프로필아미노메틸, 이소프로필아미노메틸, 부틸아미노메틸, 이소부틸아미노메틸, 펜틸아미노메틸, 1-메틸부틸아미노메틸, 헵틸아미노메틸, N,N-디에틸아미노메틸, N-부틸-N-에틸아미노메틸, N,N-디프로필아미노메틸, 피페리디노메틸, 피페라지노메틸, 피롤리디노메틸, 4-메틸피페라지노메틸, 4-메틸피레리디노메틸, 4-벤질피레라지노메틸, 4-페닐페리디노메틸, 모르폴리노메틸, N,N-디메틸아미노에틸아미노메틸, N,N-디에틸아미노에틸아미노메틸, 피페리디노에틸아미노메틸, 피페라지노에틸아미노메틸, 4-메틸리페라지노에틸아미노메틸, 4-이소프로필리페라지노에틸아미노메틸, 4-벤질피페라지노에틸아미노메틸, 2-모르폴리노에틸아미노메틸, 시클로헥실아미노메틸 또는 3-모르폴리프로필아미노메틸인 화합물.
  7. 제1~6항중 어느 한 항에 따른 화합물 및 킬레이트 결합을 통해 그와 결합된 방사성금속 원소를 함유한 킬리이트 화합물.
  8. 제7항에 있어서, 방사성 금속원소가 테크네슘-99m인 킬레이트 화합물.
  9. 제1~6항중 어느 한 항에 따른 화합물을 함유한 비방사성 담체.
  10. 제7 또는 8항에 따른 킬레이트 화합물을 함유한 방서성 진단제.
  11. 제10항에 있어서, 뇌의 혈류이매징을 위해 사용되는 방사성 진단제.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880017852A 1987-12-29 1988-12-29 킬레이트 형성 화합물 및 그의 용도 KR890009861A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62-334036 1987-12-29
JP33403687 1987-12-29

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KR890009861A true KR890009861A (ko) 1989-08-04

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US (1) US5071636A (ko)
EP (1) EP0322876A3 (ko)
KR (1) KR890009861A (ko)
AU (1) AU610322B2 (ko)
CA (1) CA1305143C (ko)
DK (1) DK728988A (ko)

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AU6362294A (en) * 1993-03-12 1994-09-26 Mallinckrodt Medical, Inc. Imidazole based nitrogen-sulfur ligands useful in radiographic imaging agents
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US6921840B1 (en) 1999-04-30 2005-07-26 The Trustees Of The University Of Pennsylvania SPECT imaging agents for serotonin transporters
AU780725B2 (en) * 1999-04-30 2005-04-14 Trustees Of The University Of Pennsylvania, The Spect imaging agents for serotonin transporters
WO2006029303A2 (en) * 2004-09-09 2006-03-16 The Trustees Of The University Of Pennsylvania Diphenyl ether derivatives and their use for imaging serotonin transporters
US10468363B2 (en) 2015-08-10 2019-11-05 X-Celeprint Limited Chiplets with connection posts
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US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
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EP0322876A2 (en) 1989-07-05
DK728988D0 (da) 1988-12-29
US5071636A (en) 1991-12-10
CA1305143C (en) 1992-07-14
DK728988A (da) 1989-06-30
EP0322876A3 (en) 1990-09-05
AU610322B2 (en) 1991-05-16
AU2755788A (en) 1989-07-13

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