KR890006652A - Antibiotic MI198 and its preparation and pesticides - Google Patents

Abstract

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Description

Antibiotic MI198 and its preparation and pesticides

As this is a public information case, the full text was not included.

1 is the ultraviolet absorption spectrum of MI198-Z ₁ material measured in ethanol.

Claims (26)

Antibiotic MI198, a compound represented by the following general formula (I): (Wherein R ¹ is an acyl group having the formula: Wherein R ³ , R ⁴ , R ⁵ and R ⁶ represent a hydrogen atom, a methyl group or an ethyl group; R ² represents a methyl group, an ethyl group or an isopropyl group) The antibiotic MI198-Z ₁ substance according to claim 1, which corresponds to a compound of formula (I) wherein R ³ and R ^{4 together} are a methyl group and R ² is a methyl group. The antibiotic MI198-Z ₂ -according to claim 1, wherein R ³ is a methyl group, R ⁴ is a hydrogen atom, an acyl group R ¹ is a trans form, and R ² is a methyl group. t substance. The antibiotic MI198-Z ₂ c according to claim 1, wherein R ³ is a hydrogen atom, R ⁴ is a methyl group, an acyl group R ¹ is a cis type, and R ² is a methyl group. matter. The antibiotic MI198-Z ₃ material according to claim 1, which corresponds to a compound of formula (I) wherein R ³ and R ^{4 together} are a methyl group and R ² is an ethyl group. The antibiotic MI198-Z _t substance according to claim 1, which corresponds to a compound of compound (I) wherein R ³ and R ⁴ are methyl groups at the same time and R ² is isopropyl group. The antibiotic MI198-Z ₅ substance according to claim 1, which corresponds to a compound of formula (I) wherein R ⁵ and R ⁶ are methyl groups at the same time, and R ² is an ethyl group. The antibiotic MI198-Z ₆ substance according to claim 1, which corresponds to a compound of formula (I) wherein R ⁵ and R ⁶ are methyl groups at the same time, and R ² is an ethyl group. The antibiotic MI198-Z ₇ -t according to claim 1, wherein R ³ is an ethyl group, R ⁴ is a methyl group, an acyl group R ¹ is a trans form, and R ² is a methyl group. matter. The antibiotic MI198-Z _7- c according to claim 1, wherein R ³ is an ethyl group, R ⁴ is a methyl group, acyl group RR ¹ is a cis type, and R ² is a methyl group. matter. The antibiotic MI198-Z ₈ -t according to claim 1, wherein R ³ is an ethyl group, R ⁴ is a methyl group, an acyl group R ¹ is a trans form, and R ² is an ethyl group. matter. The antibiotic MI198-Z ₈ -c according to claim 1, wherein R ³ is an ethyl group, R ⁴ is a methyl group, an acyl group R ¹ is a cis type, and R ² is an ethyl group. matter. The antibiotic MI198-Z ₉ substance according to claim 1, wherein R ⁵ is an ethyl group, R ⁶ is a methyl group, and is a methyl group. The antibiotic MI198-Z ₁₀ substance according to claim 1, wherein R ⁵ is an ethyl group, R ⁶ is a methyl group, and R ² is an ethyl group. The antibiotic MI198-Z ₁₁ substance according to claim 1, which corresponds to a compound of formula (I) wherein R ³ and R ⁴ are ethyl groups and R ² is a methyl group. The antibiotic MI198-Z ₁₂ substance according to claim 1, wherein R ³ and R ⁴ are ethyl groups, and R ² is an ethyl group. The antibiotic MI198-Z ₁₃ substance according to claim 1, which corresponds to a compound of formula (I) wherein R ⁵ and R ⁶ are ethyl groups and R ² is a methyl group. Incubate MI198 material-producing strains of Streptomyces in a medium containing anabolic carbon sources and anabolic nitrogen sources under aerobic conditions until the actual amount of MI198 material is produced and accumulated in the culture, and then from this culture Method for preparing an antibiotic MI198 substance represented by general formula (I), characterized by collecting the antibiotic MI198 substance which is a compound of formula (I): (Wherein R ¹ and R ² are as mentioned in claim 1) 19. The MI198 substance-producing strain according to claim 18, which is a Streptomyces hygroscopicus subspisis ureoglimosus MI198-fF29 strain identical to the accession number of the Japanese Depository "Fermentation Research Institute", FERM BP-2059. The manufacturing method to make. 19. The method of claim 18, wherein Streptomyces hygroscopicus subspisis ureole agrimosus MI198-fF29 strain (same as FERM BP-2059) is incubated under aerobic conditions at 25-35 ° C. for 5-14 days. Characterized in the manufacturing method. The method of claim 18, wherein the antibiotic MI198-Z ₁ material, MI198-Z ₂ material, MI198-Z ₃ material, MI198-Z ₄ material, MI198-Z ₅ material, MI198-Z ₆ material, MI198-Z ₇ material, When a mixture of MI198-Z ₈ , MI198-Z ₉ , MI198-Z ₁₀ , MI198-Z ₁₁ , MI198-Z _12, and MI198-Z ₁₃ is produced and accumulated Obtained by incubating Streptomyces hygroscopicus subspisis ureolacrymosus (same as FERM BP-2059) in a medium having an anabolic carbon source and an anabolic nitrogen source under aerobic conditions at a temperature of 25-35 ° C. Next, the antibiotic mixture is separated into antibiotics of each component by one or more chromatographic methods. Insecticides of adults and larvae of harmful linear animals parasitic to humans, animals or plants, characterized by containing the antibiotic MI198 substance, a compound represented by the following general formula (I): (Wherein R ¹ is an acyl group having the formula: R ³ , R ⁴ , R ⁵ and R ⁶ represent a hydrogen atom, a methyl group or an ethyl group; R ² represents a methyl group, an ethyl group or an isopropyl group) 23. The insecticide of claim 22, wherein the active ingredient is in the form of a composition consisting of MI198, a compound of formula (I), and a liquid or solid carrier for the active ingredient. An insecticide of adults, larvae or eggs of harmful Madvala animal, characterized by using MI198, a compound represented by the following general formula (I), as an active ingredient. (In the formula, R ¹ is an acyl group having the following formula; R ³ , R ⁴ , R ⁵ and R ⁶ each represent a hydrogen atom, a methyl group or an ethyl group; R ² represents a methyl group, an ethyl group or an isopropyl group) 25. The insecticide of claim 24, wherein the active ingredient is in the form of a composition consisting of MI198, a compound of formula (I), and a liquid or solid carrier for the active ingredient. The antibiotic MI198, which is a compound of formula (I), can be prepared, and Streptomyces, Haig, the same new microorganism as the culture deposited under Japanese Fermentation Research Institute Accession No. FERM BP-2059. Rosakopicus, Subspices Oureol Acrimosus. ※ Note: The disclosure is based on the initial application.