KR890002164A - Macrolide Compound - Google Patents

Abstract

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Description

Macrolide Compound

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Claims (15)

The compound represented by the following general formula (I), and its salt. Wherein R ¹ is a methyl, ethyl or isopropyl group, R ² is a hydrogen atom, a C _1-e alkyl group or a C _3-e alkenyl group, wherein = NOR ² group is an E-array and OR ³ is a hydroxyl group Or a substituted hydroxyl group having up to 25 carbon atoms. The compound of claim 1, wherein OR ³ is a methoxycarbonyloxy, acetoxy, methoxy, or hydroxyl group. The compound of claim 1, wherein OR ³ is a hydroxyl group. The compound according to any one of the preceding claims, wherein R ¹ is an isopropyl group. The compound according to any one of the preceding claims, wherein R ² is a methyl group. A compound according to claim 1, wherein R ¹ is an isopropyl group, R ² is a methyl group, and OR ³ is a hydroxy, acetoxy or methoxycarbonyloxy group. The compound of claim 1, wherein R ¹ is an isopropyl group, R ² is a methyl group, and OR ³ is a hydroxyl group. The compound according to claim 1, wherein R ¹ is a methyl group, R ² is a methyl group, OR ³ is a methoxy group, R ¹ is an ethyl group, R ² is a methyl group, and OR ³ is a hydroxyl group. A pharmaceutical composition for human medicine containing an effective amount of at least one compound of the compound according to claim 1 together with one or more carriers and / or excipients. A veterinary pharmaceutical composition containing an effective amount of at least one compound of the compound according to claim 1 together with one or more carriers and / or excipients. A pest control composition comprising an effective amount of at least one compound of the compound according to claim 1 together with one or more carriers and / or excipients. The composition according to any one of claims 9 to 11, containing an effective amount according to claim 7 together with one or more carriers and / or excipients. Agriculture, horticulture or forestry, or warehouse, building, or other public place or pest, which comprises administering to a plant or other vegetation, or to a pest itself, or to its location an effective amount of at least one compound of the compound according to claim 1 How to exterminate pests in the same place. The method of claim 13, wherein the pest is an insect, mite or nematode pest. (A) reacting a compound of formula (II) below with reagent H ₂ NOR ² (wherein R ² is as defined in claim 1) or a salt thereof, if necessary, protecting the resulting OR ³ The protecting group of the compound of formula (I), which is a hydroxyl group, or (B) R ² is C _1-e alkyl or C _3-e alkenyl, and OR ₃ is a substituted hydroxyl group, Or a compound of formula (I) in which R ² is C _1-e alkyl is a C _3-e alkenyl group, or is reacted with a reagent that converts a hydroxyl group to a substituted hydroxyl group. A compound of formula (I) wherein R ² is a hydrogen atom and OR ³ is a substituted hydroxyl group is substituted with an etherification agent R ² Y (wherein R ² is a C _1-8 alkyl or C _3-8 alkenyl group, Y after reaction with the leaving group), removing the protective group of the general formula (ⅰ) compound, oR ² is a protected hydroxyl group, if necessary, or, (D) oR ³ are of formula (ⅰ) compound a hydroxyl group When Joe, to let the reduction of a compound of formula (Ⅲ), or, (E) OR ³ is hydroxyl group in the general formula (Ⅰ) in the case of producing a compound, OR ³ a corresponding of a protected hydroxyl group When the protecting group of the compound of formula (I) is removed or (F) a salt of the acid of formula (I) is prepared, the acid is treated with a base or one salt is converted to another salt by ion exchange. The method for producing a compound according to claim 1, which is to be converted. Wherein R ¹ , R ² and OR ³ are as defined in claim 1. ※ Note: The disclosure is based on the initial application.