KR890002095A - Method for preparing quinolone derivative - Google Patents

Method for preparing quinolone derivative Download PDF

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Publication number
KR890002095A
KR890002095A KR1019870008038A KR870008038A KR890002095A KR 890002095 A KR890002095 A KR 890002095A KR 1019870008038 A KR1019870008038 A KR 1019870008038A KR 870008038 A KR870008038 A KR 870008038A KR 890002095 A KR890002095 A KR 890002095A
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KR
South Korea
Prior art keywords
hydrogen
salt
copper
alkyl group
general formula
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KR1019870008038A
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Korean (ko)
Inventor
최증권
홍성엽
김대황
Original Assignee
손영희
제일제당 주식회사
채영복
재단법인 한국화학연구소
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Application filed by 손영희, 제일제당 주식회사, 채영복, 재단법인 한국화학연구소 filed Critical 손영희
Priority to KR1019870008038A priority Critical patent/KR890002095A/en
Publication of KR890002095A publication Critical patent/KR890002095A/en

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Abstract

내용 없음No content

Description

퀴놀론 유도체의 제조방법Method for preparing quinolone derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

일반 구조식(II)의 화합물을 일반 구조식(III)의 화합물과 금속 촉매존재하에서 반응시킴을 특징으로 하는 일반 구조식(I)의 퀴놀린 유도체 및 그 염의 제조방법.A method for preparing a quinoline derivative of general formula (I) and a salt thereof, wherein the compound of general formula (II) is reacted with a compound of general formula (III) in the presence of a metal catalyst. 위 각 식에서, R1는 수소 또는 C1-C3의 저급 알킬기이고, R2는 수소, 메틸기 또는 에틸기이며, R3는 수소 C1-C5의 저급 알킬기 또는 C3-C5의 저급환 알킬기이며, X는 수소, 불소 또는 염소이며, Y는 염소 또는 브롬이다In each of the above formula, R 1 is hydrogen or lower alkyl group of C 1 -C 3 , R 2 is hydrogen, methyl or ethyl group, R 3 is hydrogen or lower alkyl group of C 1 -C 5 or lower ring of C 3 -C 5 Alkyl group, X is hydrogen, fluorine or chlorine, Y is chlorine or bromine 제1항에 있어서, 반응은 20-100℃에서 2-4시간 진행됨을 특징으로 하는 방법.The method of claim 1, wherein the reaction proceeds at 20-100 ° C. for 2-4 hours. 제2항에 있어서, 금속촉매는 구리, 코발트, 니켈의 착물 또는 그 염을 사용함을 특징으로 하는 방법.The method of claim 2, wherein the metal catalyst uses a complex of copper, cobalt, nickel, or a salt thereof. 제3항에 있어서, 구리염으로는 이염화 구리 또는 일염화구리를 사용함을 특징으로 하는 방법.4. The method according to claim 3, wherein copper salt or copper monochloride is used as the copper salt. 제1항에 있어서, 용매로 테트라히드로푸란, 디옥산등의 에테르류, 저급 알콜류 또는 디메틸포름아미드를 사용함을 특징으로 하는 방법.The method according to claim 1, wherein ethers such as tetrahydrofuran, dioxane, lower alcohols, or dimethylformamide are used as the solvent. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019870008038A 1987-07-23 1987-07-23 Method for preparing quinolone derivative KR890002095A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019870008038A KR890002095A (en) 1987-07-23 1987-07-23 Method for preparing quinolone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019870008038A KR890002095A (en) 1987-07-23 1987-07-23 Method for preparing quinolone derivative

Publications (1)

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KR890002095A true KR890002095A (en) 1989-04-08

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KR1019870008038A KR890002095A (en) 1987-07-23 1987-07-23 Method for preparing quinolone derivative

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100753905B1 (en) * 2005-09-15 2007-08-31 한국화학연구원 ?-Substituted-1?-quinoline-2,4-diones, preparation method thereof and pharmaceutical composition containing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100753905B1 (en) * 2005-09-15 2007-08-31 한국화학연구원 ?-Substituted-1?-quinoline-2,4-diones, preparation method thereof and pharmaceutical composition containing the same

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