KR890002078A - Piperazine Compounds and Antiulcer Compositions Containing the Compounds - Google Patents

Piperazine Compounds and Antiulcer Compositions Containing the Compounds Download PDF

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Publication number
KR890002078A
KR890002078A KR1019870006902A KR870006902A KR890002078A KR 890002078 A KR890002078 A KR 890002078A KR 1019870006902 A KR1019870006902 A KR 1019870006902A KR 870006902 A KR870006902 A KR 870006902A KR 890002078 A KR890002078 A KR 890002078A
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KR
South Korea
Prior art keywords
piperazine
compound
pharmaceutically acceptable
acid addition
acceptable acid
Prior art date
Application number
KR1019870006902A
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Korean (ko)
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KR940010178B1 (en
Inventor
히로시 오따까
겐지 요시다
겐지 스즈끼
고이찌 시모하라
시게루 다지마
게이조 이또
Original Assignee
가네모 가부시끼가이샤
오까모또 스스무
가네보 가부시끼 가이샤
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Priority to KR1019870006902A priority Critical patent/KR940010178B1/en
Publication of KR890002078A publication Critical patent/KR890002078A/en
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Publication of KR940010178B1 publication Critical patent/KR940010178B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

내용 없음No content

Description

피페리진 화합물 및 이 화합물을 함유한 항궤양 조성물.Piperizine compound and antiulcer composition containing the compound.

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (7)

하기 일반식의 피페라진 화합물 또는 약리학적으로 수용가능한 그의 산 부가염.Piperazine compounds of the general formula or pharmacologically acceptable acid addition salts thereof. (식중, R1 및 R2중 하나는 메톡시기이고, 다른 하나는 수소원자이다)Wherein one of R1 and R2 is a methoxy group and the other is a hydrogen atom 제1항에 있어서, 1-[(4-메톡시 페녹시)카르보닐 메틸]-4-(2,3,4-트리메톡시 벨질)피페라진 또는 약학적으로 수용 가능한 그의 산 부가염인 화합물.The compound according to claim 1, which is 1-[(4-methoxy phenoxy) carbonyl methyl] -4- (2,3,4-trimethoxy benzyl) piperazine or a pharmaceutically acceptable acid addition salt thereof. . 제1항에 있어서, 1-[{(4-메톡시 페녹시)카르보닐 메틸]-4-(2,3,4-트리메톡시 벤질)피페라진 또는 약학적으로 수용 가능한 그의 산 부가염인 화합물.The compound according to claim 1, which is 1-[{(4-methoxy phenoxy) carbonyl methyl] -4- (2,3,4-trimethoxy benzyl) piperazine or a pharmaceutically acceptable acid addition salt thereof. compound. 활성 성분으로 예방 또는 치료에 유효한 량의 하기 일반식의 피페라진 화합물 또는 약학적으로 수용 가능한 그의 산 부가염을 약학적으로 수용 가능한 담체 또는 희석제와 함께 함유하는 소화성 궤양의 예방 및 치료용 약학 조성물.A pharmaceutical composition for the prophylaxis and treatment of peptic ulcer, comprising, as an active ingredient, an effective amount of a piperazine compound of the following general formula or a pharmaceutically acceptable acid addition salt thereof together with a pharmaceutically acceptable carrier or diluent. (식중, R1및 R2중 하나는 메톡시기이고, 다른 하나는 수소원자이다).Wherein one of R 1 and R 2 is a methoxy group and the other is a hydrogen atom. 제4항에 있어서, 활성 화합물이 1-](4-메톡시 페녹시)카르보닐메틸]-4-(2,3,4-트리메톡시벤질)피페라진 또는 약학적으로 수용 가능한 그의 산 부가염인 약학 조성물.The compound according to claim 4, wherein the active compound is 1-] (4-methoxy phenoxy) carbonylmethyl] -4- (2,3,4-trimethoxybenzyl) piperazine or a pharmaceutically acceptable acid addition thereof. A pharmaceutical composition that is a salt. 제4항에 있어서, 활성 화합물이 1-](4-메톡시 페녹시)카르보닐 메틸]-4-(3,4,5-트리메톡시벤질)피페라진 또는 약학적으로 수용가능한 그의 산 부가염인 약학 조성물.The compound according to claim 4, wherein the active compound is 1-] (4-methoxy phenoxy) carbonyl methyl] -4- (3,4,5-trimethoxybenzyl) piperazine or a pharmaceutically acceptable acid addition thereof. A pharmaceutical composition that is a salt. 하기 일반식(II)의 화합물 또는 그의 산 부가염을 염기 존재하에 하기 일반식(III)의 화합물과 반응시킴을 특징으로 하는 하기 일반식(I)의 피페라진 화합물 또는 약학적으로 수용 가능한 그의 산 부가염의 제조방법.A piperazine compound of formula (I) or a pharmaceutically acceptable acid thereof, characterized by reacting a compound of formula (II) or an acid addition salt thereof with a compound of formula (III) in the presence of a base Method for preparing addition salt. (식중, R1및 R2중 하나는 메톡시기이고, 다른 하나는 수소원자이며, X는 할로겐 원자이다).(Wherein one of R 1 and R 2 is a methoxy group, the other is a hydrogen atom, and X is a halogen atom). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019870006902A 1987-07-01 1987-07-01 Piperazine compounds and anti-ulcer composition containg the same KR940010178B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019870006902A KR940010178B1 (en) 1987-07-01 1987-07-01 Piperazine compounds and anti-ulcer composition containg the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019870006902A KR940010178B1 (en) 1987-07-01 1987-07-01 Piperazine compounds and anti-ulcer composition containg the same

Publications (2)

Publication Number Publication Date
KR890002078A true KR890002078A (en) 1989-04-07
KR940010178B1 KR940010178B1 (en) 1994-10-22

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KR1019870006902A KR940010178B1 (en) 1987-07-01 1987-07-01 Piperazine compounds and anti-ulcer composition containg the same

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KR940010178B1 (en) 1994-10-22

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