KR890001698B1 - Stabilization method of pigment of lithospermi radix - Google Patents

Abstract

A method for stabilizing a pigment from a root of Lithospermum erythrorhizon is presented. Thus, a compn. of 50 wt.% polyethylene glycol (PEG) 400, 25 wt.% PEG 4,000, 1 wt.% lauryl sodium sulfate, 4 wt.% above root ext., and trace amt. of 0.05M citrate buffer soln. (pH=6.0) showed an increment of stabilization of the pigment from Lithospermum erythrorhizon, useful as a raw material of cosmetics and medicines.

Description

How to stabilize the root pigment

The accompanying drawings show the color difference measured by the colorimetric colorimeter of the cream agent prepared in each embodiment of the present invention.

The present invention relates to a method for stabilizing autologous pigments that can be used as raw materials for cosmetics and pharmaceuticals.

Root is the root of Lithospermum erythrorhizon Siebold et.Zuccarini (Lithospermum officinale Linn'e var.erythrorhizon Maximowicz) belonging to Borraginaceae. The pigment component represented by the same structural formula is contained.

Such ingredients are already used in various preparations for the purpose of anti-inflammatory, antipyretic and detoxification in oriental medicine, as well as having bactericidal and anti-inflammatory effects and are used externally as ointments for swelling, burns, frostbite, eczema, blisters and hemorrhoids. In addition, it is being used as a raw material of cosmetics in Japan recently (Third Edition, page 736 to page 747).

The pigment components of the root roots represent red (near pH 6.1), purple (near pH 8.8), and blue (near pH 10), which are used in cosmetics because the color of the pigment changes due to sunlight and inferiority. There is a problem that must be stabilized.

In order to solve this problem, in Japan, gamma-oryzanol is used (Japanese Patent Application No. 80-55108), but the study results show that the present inventors use citric acid, which is not only easier to purchase than gamma-oryzanol, but also cheaper and after treatment. The stabilizing effect is also completed the excellent invention.

That is, in the present invention, by adding the root extract extract with 0.05M-0.5M citric acid buffer solution (pH3-6) to the water-soluble cream base, the color change by the pH change and the color change by the interaction of the ciconin pigment and citric acid At the same time, it was possible to suppress it, and when producing a cream formulation containing autologous pigments according to the present invention, it was possible to more significantly improve the effect of reducing production costs and stability of the pigments.

The root extract of the root extract used in the present invention was extracted three times for 24 hours with 500 ml of an organic solvent (ether, benzene, chloroform, ethanol, etc.) three times for 24 hours, and then completely dissolved in a concentrated evaporator and redissolved in 100 ml of olive oil.

Example 1

A cream formulation was prepared according to the ingredients and contents described below.

Polyethylene glycol 400 and polyethylene glycol 4000 were dissolved in a water bath, mixed with stirring, and maintained at about 75 ° C. Sodium lauryl sulfate and the root extract were dissolved in each buffer or purified water, and the solution was pre-warmed to 75 ° C., and then mixed with stirring until it solidified, thereby preparing a cream formulation containing the root extract. At this time, 1-A, 1-B, and 1-C of the cream formulation 1 were all adjusted to pH 6 using 0.1N HC1 solution and 0.1N NaOH solution.

The prepared cream formulation was exposed to air and sunlight, and after a certain time, color difference (ΔE) was measured using a colorimeter (Model TC-1500MC, manufactured by Tokyo Denskoku Co. Ltd.) (see FIG. 1).

Example 2

A cream formulation was prepared according to the ingredients and contents described below.

White petrolatum and stearyl alcohol were dissolved in the water bath, mixed with stirring and then maintained at about 75 ° C. To this, propylene glycol, sodium lauryl sulfate, ethyl parabenzoate, and root extract were dissolved in buffer or purified water, and the solution warmed up to 75 ° C. was added to the mixture, and then mixed with stirring until it solidified to prepare a cream formulation containing the root extract. It was.

At this time, both 2-A and 2-B of cream preparation 2 were adjusted to pH 6 using 0.1N HC1 solution and 0.1N NaOH solution. The prepared cream formulations measured the color difference in the same manner as in Example 1 (see FIG. 2).

Example 3

A cream formulation was prepared in the same composition and method as in Example 2 except that the pH was adjusted to 3 using 0.5M citric acid buffer solution, and the color difference was measured (see FIG. 3).

At this time, 3-A in cream formulation 3 is 0.5M citric acid buffer solution (pH3).

Claims (2)

A method for stabilizing autologous pigments, characterized in that the root extract is added to a water-soluble cream base with 0.05-0.5M citric acid buffer solution. The method of claim 1, wherein the pH of the citric acid buffer solution is characterized in that 3-6.

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