KR880701243A - Polypeptides That Provide Protective Immunity Against Malaria - Google Patents

Polypeptides That Provide Protective Immunity Against Malaria

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KR880701243A
KR880701243A KR1019870701051A KR870701051A KR880701243A KR 880701243 A KR880701243 A KR 880701243A KR 1019870701051 A KR1019870701051 A KR 1019870701051A KR 870701051 A KR870701051 A KR 870701051A KR 880701243 A KR880701243 A KR 880701243A
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polypeptide
antigen
polynucleotide sequence
resa
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프레드릭 앤더슨 로빈
제임스 켐프 데이비드
발렌시 브라운 그라함
레온 코펠 로스
프랭크 미트첼 그라함
죤 테타츠 티모티
샤를스 우드로우 그램
호워드 고스 네일
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원본미기재
사라마네 피티와이 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6893—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56905—Protozoa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

내용 없음No content

Description

말라리아에 대한 보호 면역을 제공하는 폴리펩티드Polypeptides That Provide Protective Immunity Against Malaria

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

플라스미드 pBTA559를 제공하기 위해 pBTA395의 복수클로닝 부위 지역으로 삽입된 RESA의 천연 5′반복지역의 서열. 변위된 생성물의 예상 아미노산 서열을 제공한다.Sequence of native 5 ′ repeat region of RESA inserted into multiple cloning site region of pBTA395 to provide plasmid pBTA559. Provide the expected amino acid sequence of the displaced product.

Claims (20)

플라스모디움 팔시파룸(Plasmodium falciparum) RESA항원을 암호하는 지역으로 부터 유래되는 폴리뉴클레오디트 서열 또는 이 서열에 사이브리드 되는 폴리뉴클레오티드 서열 또는 그 첫번째 서열 또는 하이브리드 서열에 관련된 폴리뉴클레오티드 서열 또는 플라스모디움 팔시파룸의 RESA항원으로 부터 유래된 폴리펩티드를 암호하거나 또는 그 폴리펩티드와 유사한 생물학적 또는 면역학적 활성을 나타내는 폴리뉴클레오티드 서열.Plasmodium falciparum Polynucleotide sequence derived from a region encoding a RESA antigen or a polynucleotide sequence or a polynucleotide sequence that is hybridized to the sequence or a polynucleotide sequence or a plasma sequence associated with a hybrid sequence A polynucleotide sequence encoding a polypeptide derived from the RESA antigen of Sifarum or exhibiting biological or immunological activity similar to that polypeptide. 플라스모디움 팔시파룸의 RESA항원의 5′ 및 또는 3' 반복 지역으로부터 유래되는 폴리뉴클레오티드 서열, 상기 언급한 서열에 하이브리드되는 폴리뉴클레오티드 서열, 또는 상기 첫번째 폴리뉴클레오티드 서열이나 또는 그 하이브리드 서열에 관련된 폴리뉴클레오티드 서열, 또는 플리스모디움 팔시파름의 RESA항원의 5′및 또는 3′반복 지역으로부터 유래된 폴리펩티드를 암호하거나 또는 상기 폴리펩티드와 유사한 생물학적 또는 면역학적 활성을 나타내는 폴린뉴클레오티드 서열.A polynucleotide sequence derived from the 5 'and / or 3' repeat region of the RESA antigen of Plasmodium falciparum, a polynucleotide sequence hybridized to the above-mentioned sequence, or a polynucleotide related to the first polynucleotide sequence or a hybrid sequence thereof Or a polyline nucleotide sequence that encodes a polypeptide derived from the 5 'and or 3' repeat region of a RESA antigen of plismodium falcipar or exhibits biological or immunological activity similar to the polypeptide. 제1항 또는 제2항에 의한 적어도 하나의 폴리펩티드 서열의 일부분, 유사체, 동족체, 유도체 또는 조합체 또는 전체 또는 일부분, 유사체 동족체 유도체 또는 조합체의 멀티머인 폴리뉴클레이티드 서열.3. A polynucleotide sequence which is a part, analog, homologue, derivative or combination of at least one polypeptide sequence according to claim 1 or a multimer of all or part, analog homolog derivative or combination. 제1항 내지 3항중 어느 한 항에 의한 폴리뉴클레오티드를 확인하는데 있어서 유용한 프로오브로서, 폴라스모디움 팔시파룸의 RESA항원을 암호하는 지역으로부터 유래된 뉴클레오티드 서열 또는 폴라스모디움 팔시파룸의 RESA항원 지역과 유사한 생물학적 또는 면역학적 활성을 나타내는 폴리펩티드를 암호하는 서열 또는 뉴클레오티드 서열에 하이브리드하는 서열 및 라벨을 특징으로 하는 프로오브.As a useful probe in identifying the polynucleotide according to any one of claims 1 to 3, a nucleotide sequence derived from a region encoding a RESA antigen of Pallasdium falciparum or a RESA antigen of Pallasdium falciparum Probes characterized by sequences and labels that hybridize to sequences or nucleotide sequences encoding polypeptides that exhibit biological or immunological activity similar to regions. 제1항 내지 제3항중 어느 한 항에 의한 폴리뉴클레오티드 서열을 함유하는 DNA삽입체와 벡터 DNA에 의해 특징 지워지는 재조합 DNA분자.A recombinant DNA molecule characterized by a DNA insert containing a polynucleotide sequence according to any one of claims 1 to 3 and a vector DNA. 제5항에 있어서, 그벡터 DNA가 플라스미드, 비루스 또는 박테리오파아지 DNA를 포함하는 것을 특징으로 하는 재조합 DNA분자.The recombinant DNA molecule of claim 5, wherein the vector DNA comprises plasmid, virus or bacteriophage DNA. 제5항 또는 제6항에 있어서, 그것에 조작적으로 연결된 표면 조절서열을 가지는 재조합 DNA분자.The recombinant DNA molecule of claim 5 or 6, wherein the recombinant DNA molecule has a surface control sequence operably linked thereto. 제5항 내지 제7항중 어느 한 항에 의한 재조합 DNA분자로 형질 전환된 숙주.A host transformed with a recombinant DNA molecule according to any one of claims 5 to 7. 제8항에 있어서, 그 숙주 세포가 박테리아, 효모, 진균 및 고등 진핵세포로부터 선택되는 형질 전환체 숙주.The transformant host of claim 8, wherein the host cell is selected from bacteria, yeast, fungi and higher eukaryotic cells. 제8항 또는 제9항에 의한 형질 전환체 숙주의 표형 생성물.Marked product of the transformant host according to claim 8. 제10항에 있어서, 거의 순수한 형태의 표현 생성물.The product of claim 10, wherein the expression product is in nearly pure form. 플라스모디움 팔시파룸의 RESA항원의 분체들의 모너머 또는 멀티머 또는 그 분체들의 일부분, 유사체, 동족체, 유도체 또는 조합체를 포함하는 폴리펩티드 또는 그것과 유사한 생물학적 또는 면역학적 특성을 나타내는 폴리펩티드.A polypeptide comprising a monomer or multimer or portions of, or analogs, homologues, derivatives or combinations of, the powders of RESA antigens of Plasmodium falciparum, or polypeptides exhibiting similar biological or immunological properties. 제12항에 있어서, 상기 분체들이 플라스모디움 팔시파룸의 RESA항원의 5′및 또는 3′반복 단위를 포함하는 것을 특징으로 하는 폴리펩티드.The polypeptide of claim 12, wherein the powders comprise 5 ′ and 3 ′ repeat units of the RESA antigen of Plasmodium falciparum. 제12항 또는 제13항에 의한 적어도 하나의 폴리펩티드를 약학적 허용 담체 및 또는 보조제와 함께 또는 그 폴리펩티드만을 함유하는, 포유동물에서면역 반응을 자극시키기 위한 조성물.A composition for stimulating an immune response in a mammal comprising at least one polypeptide according to claim 12 or 13 together with or only with the pharmaceutically acceptable carrier and / or adjuvant. 제14항에 의한 조성물의 유효량을 포유동물에 투여하여 포유동물에 면역성을 부여하는 방법.A method of immunizing a mammal by administering to said mammal an effective amount of the composition of claim 14. 제12항 또는 제13항에 의한 적어도 하나의 폴리펩티드를 함유하는 시약을 제조하고 그것을 항-말라리아 항첼 ㅡ검출하기 위한 분석에 사용하는 것을 특징으로 하는 항-말리리아 항체의 검출 방법.A method for detecting an anti-Malia antibody, comprising preparing a reagent containing at least one polypeptide according to claim 12 or 13 and using it for analysis for anti-malaria anticheels. 제12항 또는 제13항에 의한 폴리펩티드에 대하여 유발되는 항체.An antibody raised against a polypeptide according to claim 12. 제17항에 의한 항체를 포함하는 시약을 제조하고 그것을 말라리아 항원을 검출하기 위한 분석에서 사용함을 특징으로 하는 말리리아 항원의 검출 방법.A method for detecting a Malialia antigen, comprising preparing a reagent comprising the antibody according to claim 17 and using the same in an assay for detecting a malaria antigen. (DDEHVEEPTVA)n (EENVEHDA)n 과 (EENV)n (이때 n은 양의 정수임)으로부터 선택되는 적어도 하나의 서열, 또는 삭제 및 또는 보존 치환에 의해 그로부터 유래된 관련 서열을 가지거나 함유하는 합성 펩티드를 약학적 허용 희석제 및 또는 보조제와 함께 포함하며, 그 펩티드는 임의로 담체분자에 커플될 수 있는 것을 특징으로 하는, 포유동물에서 혈액단계의 플라스모디움 팔시파룸 항원에 대한 면역조성물.A synthetic peptide having or containing at least one sequence selected from (DDEHVEEPTVA) n (EENVEHDA) n and (EENV) n, where n is a positive integer, or a related sequence derived therefrom by deletion and / or conservative substitution An immunocomposite against Plasmodium Falciparum antigen in the blood phase in a mammal, characterized in that it comprises a pharmaceutically acceptable diluent and / or adjuvant, wherein the peptide can be optionally coupled to a carrier molecule. 제19항에 있어서, 상기 합성 펩티드가(DDEHVEEPTVA)n 와 (EENVEHDA)n (이때 n은 양의 정수)으로부터 선택된 적어도 하나의 서열을 가지거나 포함하는 것을 특징으로 하는 조성물.20. The composition of claim 19, wherein said synthetic peptide has or comprises at least one sequence selected from (DDEHVEEPTVA) n and (EENVEHDA) n, where n is a positive integer. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019870701051A 1986-03-14 1987-03-13 Polypeptides That Provide Protective Immunity Against Malaria KR880701243A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPH5045/86 1986-03-14
AUPH504586 1986-03-14
AUPH559586 1986-04-23
AUPH5595/86 1986-04-23
PCT/AU1987/000071 WO1987005607A1 (en) 1986-03-14 1987-03-13 Polypeptides providing protective immunity against malaria

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EP (1) EP0297110A4 (en)
JP (1) JPS63503197A (en)
KR (1) KR880701243A (en)
IL (1) IL81890A0 (en)
WO (1) WO1987005607A1 (en)
ZW (1) ZW5087A1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213576B (en) * 1986-12-23 1989-12-20 Eniricerche Spa POLYPEPTID COMPOSITION USEFUL FOR THE PREPARATION OF ANIMALARY VACCINES AND DIAGNOSTIC KITS FOR THE DETERMINATION OF ANTI-MEROZOITE ANTIBODIES.
FR2672290B1 (en) * 1991-02-05 1995-04-21 Pasteur Institut SPECIFIC PEPTIDE SEQUENCES OF THE HEPATIC STAGES OF P. FALCIPARUM CARRIERS OF EPITOPES CAPABLE OF STIMULATING T-LYMPHOCYTES
EP0602079A1 (en) * 1991-07-31 1994-06-22 Institut Pasteur POLYPEPTIDES CAPABLE OF $i(IN VIVO) INDUCTION OF ANTIBODIES THEMSELVES CAPABLE OF INHIBITING THE INVASION OF RED BLOOD CORPUSCLES BY MEROZOITES OF $i(P.FALCIPARUM), RELATED PRODUCTS AND THEIR USE IN PRODUCING VACCINE COMPOSITIONS

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* Cited by examiner, † Cited by third party
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AU569722B2 (en) * 1983-01-28 1988-02-18 Saramane Pty Ltd Expression of plasmodium falciparum polypeptides from cloned cdna
IL76338A (en) * 1984-09-11 1994-08-26 Saramane Pty Ltd Immunogenic polypeptides of plasmodium falciparum, dna molecules encoding the polypeptides, a methodfor preparing the polypeptides and compositions containing the polypeptides
AU5603786A (en) * 1985-04-11 1986-10-16 Walter And Eliza Hall Institute Of Medical Research, The Highly repetitive antigens - sharp-arp-mesa-plasmodium falciparum
IT1213576B (en) * 1986-12-23 1989-12-20 Eniricerche Spa POLYPEPTID COMPOSITION USEFUL FOR THE PREPARATION OF ANIMALARY VACCINES AND DIAGNOSTIC KITS FOR THE DETERMINATION OF ANTI-MEROZOITE ANTIBODIES.

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EP0297110A1 (en) 1989-01-04
IL81890A0 (en) 1987-10-20
EP0297110A4 (en) 1989-12-19
JPS63503197A (en) 1988-11-24
WO1987005607A1 (en) 1987-09-24
ZW5087A1 (en) 1987-07-15

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