KR880013948A - 경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법 - Google Patents

경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법 Download PDF

Info

Publication number
KR880013948A
KR880013948A KR870005217A KR870005217A KR880013948A KR 880013948 A KR880013948 A KR 880013948A KR 870005217 A KR870005217 A KR 870005217A KR 870005217 A KR870005217 A KR 870005217A KR 880013948 A KR880013948 A KR 880013948A
Authority
KR
South Korea
Prior art keywords
piperacillin
pivaloyloxymethyl ester
preparing oral
general formula
iii
Prior art date
Application number
KR870005217A
Other languages
English (en)
Other versions
KR890003624B1 (ko
Inventor
강승안
Original Assignee
강승안
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 강승안 filed Critical 강승안
Priority to KR1019870005217A priority Critical patent/KR890003624B1/ko
Priority to JP62161442A priority patent/JPS63297388A/ja
Publication of KR880013948A publication Critical patent/KR880013948A/ko
Application granted granted Critical
Publication of KR890003624B1 publication Critical patent/KR890003624B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 피페라실린 피발로일옥시메틸에스테르의 HPLC 크로마토그램을 나타내며, 제2도는 25℃에서, 피페라실린과 피페라실린 피발로일옥시메틸에스테르의 용해도 -pH곡선을 나타내며, 제3도는 제1액(pH 1.2±0.1)에서 피페라실린과 피페라실린 피발로일옥시메틸에스테르의 용출곡선(37±0.5℃).

Claims (1)

  1. 일반식(Ⅱ)
    (식중, M은 수소 또는 알칼리금속을 나타낸다.)의 피페라실린 또는 그 알칼리금속염을 일반식(Ⅲ)
    X-CH2-O-COC(CH3)3(Ⅲ)
    (식중, X는 할로겐을 타나낸다.)의 할로 메틸 피발레이트와 반응시켜, 일반식(Ⅰ)
    의 피페라실린 피발로일옥시메틸에스테르를 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870005217A 1987-05-26 1987-05-26 경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법 KR890003624B1 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019870005217A KR890003624B1 (ko) 1987-05-26 1987-05-26 경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법
JP62161442A JPS63297388A (ja) 1987-05-26 1987-06-30 経口用ピペラシリンピバロイルオキシメチルエステル及びその製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019870005217A KR890003624B1 (ko) 1987-05-26 1987-05-26 경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법

Publications (2)

Publication Number Publication Date
KR880013948A true KR880013948A (ko) 1988-12-22
KR890003624B1 KR890003624B1 (ko) 1989-09-28

Family

ID=19261648

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870005217A KR890003624B1 (ko) 1987-05-26 1987-05-26 경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법

Country Status (2)

Country Link
JP (1) JPS63297388A (ko)
KR (1) KR890003624B1 (ko)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5123284A (en) * 1974-08-13 1976-02-24 Toyama Chemical Co Ltd Shinkina penishirinruino seizoho

Also Published As

Publication number Publication date
JPS63297388A (ja) 1988-12-05
KR890003624B1 (ko) 1989-09-28

Similar Documents

Publication Publication Date Title
KR840005083A (ko) 항고혈압제로서 유용한 아미노산유도체의 제조방법
UA5953A1 (uk) Спосіб отримання похідних сульфонілмочевин
IL75133A (en) Process for the preparation of 1,2-diacyl-s,n-glycerophosphocholines(or glycerophosphoethanolamines)and some novel intermediates therefor
AU5034879A (en) Acid addition salt of 2beta,16beta diperidino 5 alpha androstane derivatives
KR830002722A (ko) 이미다졸리딘 유도체의 제조방법
KR840001152A (ko) 신규 복소환(複素環) 화합물의 제법
CH672225GA3 (ko)
KR880013948A (ko) 경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법
KR830001936A (ko) 벤조디아제핀 유도체의 제조방법
KR850008159A (ko) 2-페닐-4,5,6,7-테트라히드로-2h-인다졸류의 제조방법
KR860009019A (ko) 항세균 작용 및 β- 락타마제 억제 작용을 갖는 퀴놀린- 락타민 유도체의 제조 방법
KR850006191A (ko) 티오시아노 피리미딘 유도체의 제조방법
DE3463143D1 (en) 1-0-alkyl-3-amino-propan-1.2-diol-2-0-phospholipids, process for producing the same and pharmaceutical preparations containing the same
AU533275B2 (en) 2-amino or 2-thio derivatives of 4,5-diphenyl-oxazole
KR840000482A (ko) 시스틴 유도체의 제조방법
KR840003639A (ko) 이속사졸로피리미딘 유도체의 제조방법
KR830005179A (ko) 아세트 아닐리드의 제조방법
KR850002455A (ko) 2,2-디클로로-3,3-메틸시클로프로필메틸아민의 제조방법
KR860006483A (ko) 시타라빈 유도체의 제조방법
KR840001957A (ko) 신규의 이소프로필 아미노 피리미딘 유도체의 제조방법
KR860004008A (ko) 부타놀유도체의 제법
KR830007673A (ko) 아미노-페니실린 유도체의 제조방법
KR870008913A (ko) 브라시노라이드 유사체의 제조방법
KR830010080A (ko) 5-(3-클로로-4-하이드록시페닐)-3-하이드록시메틸히단토인의 제조방법
KR860008146A (ko) 아졸-1-일-메탄 유도체의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 19940926

Year of fee payment: 6

LAPS Lapse due to unpaid annual fee