KR880013945A - Method for preparing penicillin and cephalosporin derivatives - Google Patents

Method for preparing penicillin and cephalosporin derivatives Download PDF

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Publication number
KR880013945A
KR880013945A KR870005098A KR870005098A KR880013945A KR 880013945 A KR880013945 A KR 880013945A KR 870005098 A KR870005098 A KR 870005098A KR 870005098 A KR870005098 A KR 870005098A KR 880013945 A KR880013945 A KR 880013945A
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KR
South Korea
Prior art keywords
derivatives
formula
hydrogen
hydroxy
sodium
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KR870005098A
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Korean (ko)
Inventor
이덕근
김진웅
이상무
유무영
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손영희
제일제당 주식회사
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Priority to KR870005098A priority Critical patent/KR880013945A/en
Publication of KR880013945A publication Critical patent/KR880013945A/en

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Abstract

내용 없음No content

Description

페니실린 및 세팔로스포린 유도체의 제조방법Method for preparing penicillin and cephalosporin derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

일반식(Ⅱ)의 혼합무수물의 3급 아민염을 일반식(Ⅲ)의 무기염기 존재하에서 유기 용매와 수용액의 2상에서 일반식(Ⅳ)의 6-아미노페니실란산 및 그 유도체나 7-아미노세팔로스포란산 및 그 유도체와 반응시킴을 특징으로 하는 일반식(Ⅰ)의 페닐실린 및 세팔로스포린 유도체의 제조방법.Tertiary amine salt of the mixed anhydride of formula (II) in the presence of an inorganic base of formula (III) in the presence of an organic solvent and an aqueous solution in phase 2 of 6-aminophenic silane acid and its derivatives or 7-amino A process for the preparation of phenylsilin and cephalosporin derivatives of formula (I) characterized by reacting with cephalosporan acid and derivatives thereof. 상기 식에서 M은 수소 또는 나트륨, R1, R2는 C1-3저급알킬, Y는 하이드록시기 또는 탄산수소기이며 A는Wherein M is hydrogen or sodium, R 1 , R 2 is C 1-3 lower alkyl, Y is hydroxy or hydrogen carbonate and A is 또는 or 이다. (여기에서 M은 수소 또는 나트륨, R은 하이드록시, 아세톡시 또는 1개의 4급 질소를 함유하고 또한 카바모일기로 치환되어도 좋은 6원환 복소환이다.)to be. (Wherein M is hydrogen or sodium, R is hydroxy, acetoxy or one quaternary nitrogen and is a six-membered heterocycle which may be substituted with a carbamoyl group.) 제1항에 있어서, 유기 용매는 메틸렌클로라이드, 1.2-디클로로에탄, 클로로포름 중에서 선택된 것임을 특징으로 하는 방법.The method of claim 1 wherein the organic solvent is selected from methylene chloride, 1.2-dichloroethane, chloroform. 제1항에 있어서, 아실화 반응은 0℃내지 실온사이의 온도에서 1-2시간 내로 행함을 특징으로 하는 방법.The process according to claim 1, wherein the acylation reaction is carried out within 1-2 hours at a temperature between 0 ° C. and room temperature. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR870005098A 1987-05-22 1987-05-22 Method for preparing penicillin and cephalosporin derivatives KR880013945A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR870005098A KR880013945A (en) 1987-05-22 1987-05-22 Method for preparing penicillin and cephalosporin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR870005098A KR880013945A (en) 1987-05-22 1987-05-22 Method for preparing penicillin and cephalosporin derivatives

Publications (1)

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KR880013945A true KR880013945A (en) 1988-12-22

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KR870005098A KR880013945A (en) 1987-05-22 1987-05-22 Method for preparing penicillin and cephalosporin derivatives

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KR (1) KR880013945A (en)

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