KR880009988A - Method for preparing β-L-aspartyl-L-phenylalanine methyl ester - Google Patents

Method for preparing β-L-aspartyl-L-phenylalanine methyl ester Download PDF

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Publication number
KR880009988A
KR880009988A KR870001295A KR870001295A KR880009988A KR 880009988 A KR880009988 A KR 880009988A KR 870001295 A KR870001295 A KR 870001295A KR 870001295 A KR870001295 A KR 870001295A KR 880009988 A KR880009988 A KR 880009988A
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South Korea
Prior art keywords
aspartyl
phenylalanine
preparing
methyl ester
phenylalanine methyl
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KR870001295A
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Korean (ko)
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KR900002557B1 (en
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박정용
박동진
안도영
Original Assignee
허영섭
주식회사 녹십사
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Priority to KR1019870001295A priority Critical patent/KR900002557B1/en
Publication of KR880009988A publication Critical patent/KR880009988A/en
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Publication of KR900002557B1 publication Critical patent/KR900002557B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음.No content.

Description

β-L-아스파르틸-L-페닐알라닌 메틸에스테르의 제조방법Method for preparing β-L-aspartyl-L-phenylalanine methyl ester

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (5)

β-L아스파르틸-L-페닐알라닌 메틸에스테르를 제조하는 방법에 있어서, L-아스파르트산 무수물의 알킬황산염과 L-페닐알라닌을 물 또는 소량의 극성용매의 혼합용액 중에서 낮은 온도 및 높은 pH를 유지하면서 반응시킨 후 보호기를 제거함을 특징으로 하는 방법.A method for preparing β-L aspartyl-L-phenylalanine methyl ester, wherein the alkyl sulfate and L-phenylalanine of L-aspartic anhydride are kept in water or a mixed solution of a small amount of polar solvent while maintaining a low temperature and a high pH. Removing the protecting group after the reaction. 제1항에 있어서, 아스파르트산 무수물의 알킬황산염의 알킬기가 메틸, 이소프로필 또는 t-부틸기인 것이 특징인 방법.The method according to claim 1, wherein the alkyl group of the alkyl sulfate of aspartic anhydride is a methyl, isopropyl or t-butyl group. 제1항에 있어서, 반응온도가 -20~10℃인 것이 특징인 방법.The method of claim 1, wherein the reaction temperature is -20 ~ 10 ℃. 제1항에 있어서, pH가 8~13인 것이 특징인 방법.The method of claim 1 wherein the pH is 8-13. 제1항에 있어서, β-L-아스파르틸-L-페닐알라닌 메닐에스테르 염산염을 분리한 모액에 β-L-아스파르틸-L-메닐알라닌에 대해 0.5~5몰 당량에 해당하는 염산, 메탄올을 가해 β-L-아스파르틸-L-페닐알라닌 메닐에스테르를 제조하는 방법.The hydrochloric acid and methanol according to claim 1, wherein 0.5 to 5 molar equivalents of β-L-aspartyl-L-menylalanine is added to the mother liquor from which β-L-aspartyl-L-phenylalanine menylester hydrochloride is separated. Adding to prepare β-L-aspartyl-L-phenylalanine menyl ester. ※참고사항:최초출원 내용에 의하여 공개하는 것임.※ Note: This is to be disclosed based on the first application.
KR1019870001295A 1987-02-17 1987-02-17 Process for preparation of alpha-l-aspartyl-2-phenyl-alamine methylester KR900002557B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019870001295A KR900002557B1 (en) 1987-02-17 1987-02-17 Process for preparation of alpha-l-aspartyl-2-phenyl-alamine methylester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019870001295A KR900002557B1 (en) 1987-02-17 1987-02-17 Process for preparation of alpha-l-aspartyl-2-phenyl-alamine methylester

Publications (2)

Publication Number Publication Date
KR880009988A true KR880009988A (en) 1988-10-06
KR900002557B1 KR900002557B1 (en) 1990-04-20

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ID=19259489

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870001295A KR900002557B1 (en) 1987-02-17 1987-02-17 Process for preparation of alpha-l-aspartyl-2-phenyl-alamine methylester

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Publication number Publication date
KR900002557B1 (en) 1990-04-20

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