KR880009006A - Method for preparing 1,2-dithiol-3-thione derivative - Google Patents

Method for preparing 1,2-dithiol-3-thione derivative Download PDF

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Publication number
KR880009006A
KR880009006A KR870009838A KR870009838A KR880009006A KR 880009006 A KR880009006 A KR 880009006A KR 870009838 A KR870009838 A KR 870009838A KR 870009838 A KR870009838 A KR 870009838A KR 880009006 A KR880009006 A KR 880009006A
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KR
South Korea
Prior art keywords
dithiol
thione
butadienyl
formula
derivative
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Application number
KR870009838A
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Korean (ko)
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KR900000968B1 (en
Inventor
이타루 야마모도
아기라 마쯔바라
간지 도미야
오사무 미즈노
미쯔히로 사까구찌
미끼오 구마구라
Original Assignee
사와무라 하루오
미쯔이 도아쯔 가가꾸 가부시기가이샤
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Publication of KR880009006A publication Critical patent/KR880009006A/en
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Publication of KR900000968B1 publication Critical patent/KR900000968B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.No content.

Description

1,2-디티올-3-티온 유도체의 제조방법Method for preparing 1,2-dithiol-3-thione derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (4)

하기식 (I)의 1,2-디티올-3-티온 유도체.1,2-dithiol-3-thione derivatives of the formula (I). 상기식에서 R은 수소, 할로겐, 저급알콕시, 저급알킬, 아미노, 저급-알킬치환된 아미노 또는 저급알콕시 카르보닐기.Wherein R is hydrogen, halogen, lower alkoxy, lower alkyl, amino, lower-alkyl substituted amino or lower alkoxy carbonyl group. 제1항에 있어서, 5-(4-페닐-1,3-부타디에닐)-1,2-디티올-3-티온, 5-{4-(4-클로로페닐)-1,3-부타디에닐}-1,2-디티올-3-티온, 5-{4-(4-메톡시페닐)-1,3-부타디에닐}-1,2-디티올-3-티온, 5-{4-(p-톨루일)-1,3-부타디에닐}-1,2-디티올-3-티온, 5-{4-(O-클로로페닐)-1,3-부타디에닐}-1,2-디티올-3-티온, 5-{4-(m-메틸페닐)-1,3-부타디에닐}-1,2-디티올-3-티온인 유도체.The method of claim 1, wherein 5- (4-phenyl-1,3-butadienyl) -1,2-dithiol-3-thione, 5- {4- (4-chlorophenyl) -1,3-buta Dienyl} -1,2-dithiol-3-thione, 5- {4- (4-methoxyphenyl) -1,3-butadienyl} -1,2-dithiol-3-thione, 5- {4- (p-toluyl) -1,3-butadienyl} -1,2-dithiol-3-thione, 5- {4- (O-chlorophenyl) -1,3-butadienyl} Derivatives which are -1,2-dithiol-3-thione, 5- {4- (m-methylphenyl) -1,3-butadienyl} -1,2-dithiol-3-thione. 염기존재하의 유기용매내에서 하기식 (II)의 알데하이드 화합물을 5-메틸-1,2-디티올-3-티온 유도체와 축합하는 것으로 구성된 하기식 (I)의 1,2-디티올-3-티온 유도체의 제조방법.1,2-dithiol-3 of formula (I) consisting of condensing an aldehyde compound of formula (II) with a 5-methyl-1,2-dithiol-3-thione derivative in an organic solvent in the presence of a base -Method of preparing a thion derivative. 상기식에서 R은 수소, 할로겐, 저급알콕시, 저급알킬, 아미노, 저급알킬 치환된 아미노 또는 저급알콕시 카르보닐.Wherein R is hydrogen, halogen, lower alkoxy, lower alkyl, amino, lower alkyl substituted amino or lower alkoxy carbonyl. 청구범위 제1항의 식 (I)의 1,2-디티올-3-티온 유도체의 유효량과 약학적으로 허용가능한 담체로 구성된 면역조절 조성물.An immunomodulatory composition comprising an effective amount of a 1,2-dithiol-3-thione derivative of formula (I) of claim 1 and a pharmaceutically acceptable carrier. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019870009838A 1986-03-05 1987-09-04 1,2-dithiol-3-thione derivative composition and their preparation KR900000968B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP4631886 1986-03-05
JP?61-46318 1986-03-05
JP62018295A JPS6310785A (en) 1986-03-05 1987-01-30 Novel 1,2-dithiol-3-thione derivative, production thereof and immunoregulating agent containing said compound as active ingredient
JP?62-18295 1987-01-30
JP62-018295 1987-01-30

Publications (2)

Publication Number Publication Date
KR880009006A true KR880009006A (en) 1988-09-13
KR900000968B1 KR900000968B1 (en) 1990-02-23

Family

ID=12743812

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870009838A KR900000968B1 (en) 1986-03-05 1987-09-04 1,2-dithiol-3-thione derivative composition and their preparation

Country Status (2)

Country Link
JP (1) JPS6310785A (en)
KR (1) KR900000968B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100484526B1 (en) * 2002-11-13 2005-04-20 씨제이 주식회사 Thione derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH089611B2 (en) * 1988-06-20 1996-01-31 三井東圧化学株式会社 Novel 1,2-dithiole-3-thione derivative and immunomodulator containing the same as active ingredient
JPH0816059B2 (en) * 1993-05-21 1996-02-21 三井東圧化学株式会社 Immunomodulator

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100484526B1 (en) * 2002-11-13 2005-04-20 씨제이 주식회사 Thione derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
KR900000968B1 (en) 1990-02-23
JPH0440356B2 (en) 1992-07-02
JPS6310785A (en) 1988-01-18

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