KR880003634A - Method of stabilization of interferon ointment - Google Patents

Method of stabilization of interferon ointment Download PDF

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Publication number
KR880003634A
KR880003634A KR1019860007559A KR860007559A KR880003634A KR 880003634 A KR880003634 A KR 880003634A KR 1019860007559 A KR1019860007559 A KR 1019860007559A KR 860007559 A KR860007559 A KR 860007559A KR 880003634 A KR880003634 A KR 880003634A
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KR
South Korea
Prior art keywords
interferon
adjusted
buffer solution
solution
ion concentration
Prior art date
Application number
KR1019860007559A
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Korean (ko)
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KR890000652B1 (en
Inventor
김제학
정인환
조남진
김현수
유무영
Original Assignee
손영희
제일제당주식회사
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Application filed by 손영희, 제일제당주식회사 filed Critical 손영희
Priority to KR1019860007559A priority Critical patent/KR890000652B1/en
Publication of KR880003634A publication Critical patent/KR880003634A/en
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Publication of KR890000652B1 publication Critical patent/KR890000652B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Abstract

내용 없음No content

Description

인터페론 연고제의 안정화 방법Method of stabilization of interferon ointment

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (10)

인터페론 액의 수소 이온 농도를 완충 용액을 사용하여 조절한 다음, 폴리에틸렌 기제에 혼합함을 특징으로 하는 인터페론 연고제의 안정화방법.A method of stabilizing interferon ointment, characterized in that the hydrogen ion concentration of the interferon solution is adjusted using a buffer solution, and then mixed in a polyethylene base. 제1항에 있어서, 인터페론 액의 수소 이온 농도를 0.1M HCl·KH2PO4완충 용액을 사용하여 pH 2-4로 조절하는 것을 특징으로 하는 방법.The method according to claim 1, wherein the hydrogen ion concentration of the interferon liquid is adjusted to pH 2-4 using 0.1M HCl.KH 2 PO 4 buffer solution. 제1항에 있어서, 인터페론 액의 수소 이온 농도를 1M HCl·Na Citrate 완충 용액을 사용하여 pH 2-5로 조절하는 것을 특징으로 하는 방법.The method of claim 1, wherein the hydrogen ion concentration of the interferon liquid is adjusted to pH 2-5 using 1M HCl NaClit buffer solution. 제1항에 있어서, 인터페론액의 수소 이온 농도를 0.1M HCl·Na Citrate 완충 용액을 사용하여 pH 2-5로 조절하는 것을 특징으로 하는 방법.The method of claim 1, wherein the hydrogen ion concentration of the interferon solution is adjusted to pH 2-5 using 0.1M HCl NaClit buffer solution. 제1항에 있어서, 인터페론 액의 수소 이온 농도를 0.01M HCl·Na Citrate 완충 용액을 사용하여 pH 2-6으로 조절하는 것을 특징으로 하는 방법.The method of claim 1, wherein the hydrogen ion concentration of the interferon solution is adjusted to pH 2-6 using 0.01 M HCl NaClit buffer solution. 제1항에 있어서, 인터페론 액의 수소 이온 농도를 40mM Citric acid·Na Citrate 완충 용액을 사용하여 pH 3-5로 조절하는 것을 특징으로 하는 방법.The method of claim 1, wherein the concentration of hydrogen ions in the interferon solution is adjusted to pH 3-5 using a 40 mM Citric acid-Na Citrate buffer solution. 제1항에 있어서, 인터페론 액의 수소 이온 농도를 40mM Citric acid· Na2HPO4완충 용액을 사용하여 pH 3-6으로 조절하는 것을 특징으로 하는 방법.The method of claim 1, wherein the concentration of hydrogen ions in the interferon solution is adjusted to pH 3-6 using a 40 mM Citric acid Na 2 HPO 4 buffer solution. 제1항에 있어서, 인터페론 액의 수소 이온 농도를 0.1M Citrate·Na2HPO4완충 용액을 사용하여 pH 3-5으로 조절하는 것을 특징으로 하는 방법.The method according to claim 1, wherein the hydrogen ion concentration of the interferon solution is adjusted to pH 3-5 using 0.1 M Citrate Na 2 HPO 4 buffer solution. 제1항에 있어서, 인터페론 액의 수소 이온 농도를 0.1M CH3COONa·HCl 완충 용액을 사용하여 pH 4-6으로 조절하는 것을 특징으로 하는 방법.The method of claim 1, wherein the hydrogen ion concentration of the interferon liquid is adjusted to pH 4-6 using 0.1 M CH 3 COONa.HCl buffer solution. 제1항에 있어서, 인터페론 액의 수소 이온 농도를 0.1M Na2HPO4·NaH2PO4완충 용액을 사용하여 pH 5-6으로 조절하는 것을 특징으로 하는 방법.The method according to claim 1, wherein the hydrogen ion concentration of the interferon liquid is adjusted to pH 5-6 using 0.1 M Na 2 HPO 4 NaH 2 PO 4 buffer solution. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019860007559A 1986-09-09 1986-09-09 Method of stabilization of interferon ointment KR890000652B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019860007559A KR890000652B1 (en) 1986-09-09 1986-09-09 Method of stabilization of interferon ointment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019860007559A KR890000652B1 (en) 1986-09-09 1986-09-09 Method of stabilization of interferon ointment

Publications (2)

Publication Number Publication Date
KR880003634A true KR880003634A (en) 1988-05-28
KR890000652B1 KR890000652B1 (en) 1989-03-22

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Application Number Title Priority Date Filing Date
KR1019860007559A KR890000652B1 (en) 1986-09-09 1986-09-09 Method of stabilization of interferon ointment

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KR890000652B1 (en) 1989-03-22

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