KR880002881A - Cefem compound - Google Patents

Abstract

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Description

Cefem compound

Since this is an open matter, no full text was included.

Claims (13)

A compound of formula (I): In food; Q represents a nitrogen atom or CH; R ¹ is a hydrogen atom or an optionally substituted lower alkyl group; R ² is a hydrogen atom or a lower alkyl group; A represents a sulfur atom or NH; And n is an integer from 2 to 4. The compound of formula (I) or a salt thereof according to claim 1, wherein Q is CH. The compound of formula (I) or a salt thereof according to claim 1, wherein Q is a nitrogen atom. The compound of formula (I) or a salt thereof according to any one of claims 1 to 3, wherein R ² is a hydrogen atom. The compound of formula (I) or a salt thereof according to any one of claims 1 to 3, wherein A is a sulfur atom. The compound of formula (I) or a salt thereof according to claim 1, which is a compound represented by the following formula (I '). (Wherein R ¹ and n are as defined in claim 1). The linear or branched alkyl group of 1 to 6 carbon atoms according to claim 1 or 6, wherein R ¹ is substituted with 1 to 3 substituents selected from vinyl group, carboxy group, C _1-6 -alkoxycarbonyl group, amino group, hydroxy group and halogen. A compound of formula (I) or a salt thereof. The compound of claim 1, wherein 7β- [2-2aminothiazol-4-yl)-(Z) -2-ethoxyiminoacetamino] -3 {[4- (3-aminopropylthio) -1- A compound of formula (I) or a salt thereof, wherein the compound is pyridinium] methyl} -3-cepem-4-carboxylate. Reacting a compound of the general formula (II) or a salt thereof with a compound of the general formula (III) or a salt thereof, and then removing the protecting group (s) in any order as Or a free base and / or a resulting free acid or free base to a corresponding pharmaceutically acceptable salt. Wherein Q represents a nitrogen atom or CH; R ¹ is a hydrogen atom or an optionally substituted lower alkyl group; R ² is a hydrogen atom or a lower alkyl group; R ³ is an optionally protected amino group; R ⁴ is a hydroxy group, an acyl An oxy group, a carbamoyloxy group, a substituted carbamoyloxy group or a halogen; R ⁵ is an amino-protecting group; A represents a sulfur atom or NH; and n is an integer from 2 to 4.) Reacting a compound of formula (IV) or a salt thereof with a reactive derivative in a compound of formula (V) or a carboxyl group thereof, followed by removing the protecting group (s) Process for the preparation of the compound of formula (I) . Wherein Q represents a nitrogen atom or CH; R ¹ is a hydrogen atom or an optionally substituted lower alkyl group; R ² is a hydrogen atom or a lower alkyl group; R ³ is an optionally protected amino group; R ⁵ is an amino-protecting group A is a sulfur atom or NH and n is an integer from 2 to 4. Reacting a compound of formula (VII) or a salt thereof with a compound of formula (VIII) or a reactive derivative thereof, followed by removal of the protecting group (s) in any order as A process for preparing a compound of formula (I): Wherein Q represents a nitrogen atom or CH; R ¹ is a hydrogen atom or an optionally substituted lower alkyl group; R ² is a hydrogen atom or a lower alkyl group; R ³ is an optionally protected amino group; R ⁵ is an amino-protecting group A represents a sulfur atom or NH; and n is an integer from 2 to 4; and R ^{1 '} is an optionally substituted lower alkyl group.) Reacting a compound of formula (VII): Or a process for preparing a compound of formula (I ″) or a salt thereof, characterized by converting the resulting free acid or free base to the corresponding pharmaceutically acceptable salt. Wherein R ¹ is a hydrogen atom or an optionally substituted lower alkyl group; R ² is a hydrogen atom or a lower alkyl group; R ⁵ is an amino-protecting group; A is a sulfur atom or NH; n is an integer from 2 to 4; and X is halogen.) An antimicrobial composition containing at least one effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof and a suitable carrier (s). Wherein Q represents a nitrogen atom or CH; R ¹ is a hydrogen atom or an optionally substituted lower alkyl group; R ² is a hydrogen atom or a lower alkyl group; A is a sulfur atom or NH; and n is an integer from 2 to 4 .) ※ Note: The disclosure is based on the initial application.