KR880002871A - Process for preparing pyrrolodiazepine compound - Google Patents

Process for preparing pyrrolodiazepine compound Download PDF

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Publication number
KR880002871A
KR880002871A KR1019860007038A KR860007038A KR880002871A KR 880002871 A KR880002871 A KR 880002871A KR 1019860007038 A KR1019860007038 A KR 1019860007038A KR 860007038 A KR860007038 A KR 860007038A KR 880002871 A KR880002871 A KR 880002871A
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KR
South Korea
Prior art keywords
group
pyrrolodiazepine
hydrogen
carbon atoms
preparing
Prior art date
Application number
KR1019860007038A
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Korean (ko)
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KR880002088B1 (en
Inventor
홍성표
Original Assignee
홍성표
주식회사 일화
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Application filed by 홍성표, 주식회사 일화 filed Critical 홍성표
Priority to KR1019860007038A priority Critical patent/KR880002088B1/en
Publication of KR880002871A publication Critical patent/KR880002871A/en
Application granted granted Critical
Publication of KR880002088B1 publication Critical patent/KR880002088B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

내용 없음No content

Description

피롤로디아제핀 화합물의 제조방법Process for preparing pyrrolodiazepine compound

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (1)

다음 일반식(Ⅱ)의 벤질아미노 아세트아미드피롤 유도체를 저급알카놀 내에서 금속 촉매를 사용하여 접촉 수소화시킨 다음, 생성된 일반식(Ⅱ)의 아미노 유도체를 산과 함께 가열하여 폐환시킴을 특징으로 하는 일반식(Ⅰ)의 피롤로디아제핀의 제조방법.Next, the benzylamino acetamide pyrrole derivative of formula (II) is subjected to catalytic hydrogenation in a lower alkanol by using a metal catalyst, and then the amino derivative of formula (II) is heated with an acid for cyclization. Method for producing pyrrolodiazepine of general formula (I). (여기에서, R은 수소, 탄소수 1-4의 알킬기이고, R1은 수소, 탄소수 1-2의 알킬기 또는 페닐기이며 R2는 메틸기, R3는 수소, 탄소수 1-2의 알킬기, 할로겐 또는 -OH기이고 R4는 벤질기이다)(Wherein R is hydrogen, an alkyl group having 1-4 carbon atoms, R 1 is hydrogen, an alkyl group having 1-2 carbon atoms or a phenyl group, R 2 is a methyl group, R 3 is hydrogen, an alkyl group having 1-2 carbon atoms, halogen or- OH group and R 4 is benzyl group) ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019860007038A 1986-08-25 1986-08-25 Process for preparation of pyrrolodiazepines KR880002088B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019860007038A KR880002088B1 (en) 1986-08-25 1986-08-25 Process for preparation of pyrrolodiazepines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019860007038A KR880002088B1 (en) 1986-08-25 1986-08-25 Process for preparation of pyrrolodiazepines

Publications (2)

Publication Number Publication Date
KR880002871A true KR880002871A (en) 1988-05-12
KR880002088B1 KR880002088B1 (en) 1988-10-15

Family

ID=19251910

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860007038A KR880002088B1 (en) 1986-08-25 1986-08-25 Process for preparation of pyrrolodiazepines

Country Status (1)

Country Link
KR (1) KR880002088B1 (en)

Also Published As

Publication number Publication date
KR880002088B1 (en) 1988-10-15

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