KR880001673A - Method for preparing cephalosporin derivative - Google Patents

Method for preparing cephalosporin derivative Download PDF

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Publication number
KR880001673A
KR880001673A KR1019860005314A KR860005314A KR880001673A KR 880001673 A KR880001673 A KR 880001673A KR 1019860005314 A KR1019860005314 A KR 1019860005314A KR 860005314 A KR860005314 A KR 860005314A KR 880001673 A KR880001673 A KR 880001673A
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KR
South Korea
Prior art keywords
group
hydrogen
following structural
structural formula
alkyl
Prior art date
Application number
KR1019860005314A
Other languages
Korean (ko)
Inventor
김완주
이철해
김경숙
Original Assignee
채영복
재단법인 한국화학연구소
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 채영복, 재단법인 한국화학연구소 filed Critical 채영복
Priority to KR1019860005314A priority Critical patent/KR880001673A/en
Priority to JP62155236A priority patent/JPS6322585A/en
Priority to DE19873721305 priority patent/DE3721305A1/en
Priority to IT8721133A priority patent/IT1206796B/en
Priority to GB08715337A priority patent/GB2193213A/en
Publication of KR880001673A publication Critical patent/KR880001673A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings
    • C07F9/65188—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음No content

Description

세팔로스포린 유도체의 제조방법Method for preparing cephalosporin derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

세팔로스포린 유됴체를 제조하는 데 있어서, 유기용매 중에서 다음 구조식(Ⅲ)으로 표시되는 유기산 다음 구조식(Ⅳ)로 표시되는 화합물을 반응시키되 다음 구조식(Ⅱ)로 표시되는 축합제의 존재하에서 반응시켜서 됨을 특징을 하는 다음 구조식(Ⅰ)으로 표시되는 세팔로스포린 유도체를 제조하는 방법.In preparing the cephalosporin emulsion, the organic acid represented by the following structural formula (III) in the organic solvent is reacted with the compound represented by the following structural formula (IV), but in the presence of a condensing agent represented by the following structural formula (II) Method for preparing a cephalosporin derivative represented by the following structural formula (I) characterized in that. 상기 식에서 R은 일반식의 α -치환아릴메틸 또는 헤테로 아릴메틸(이때 R'는 페닐, 할로겐이나 히드록시로 치환된 페닐이고, Q는 보호히드록시, 보호아미노 또는 보호카르복실이거나 우레이드 형태의 치환기를 표시함)이거나 또는 일반식의 α-옥시아미노기(이때 R"는 푸릴 또는의 기로서 여기서 a는 수소나 아민기이고 X는 CH 또는 N을 나타내며, Y는 수소, C1-C5알킬, 일케닐, 알키닐 또는 시클로알킬기임).In which R is a general formula Α-substituted arylmethyl or hetero arylmethyl wherein R 'is phenyl, phenyl substituted by halogen or hydroxy, and Q is protected hydroxy, protected amino or protected carboxyl or represents a fluoride type substituent Or general formula Α-oxyamino group wherein R ″ is furyl or Wherein a is hydrogen or an amine group and X represents CH or N, and Y is hydrogen, a C 1 -C 5 alkyl, ilkenyl, alkynyl or cycloalkyl group. z은 수소 또는 할로겐 원자이거나 5개 이하의 탄소원자를 갖는 알킬, 시클로알킬, 알콕시 또는 알킬티오기들, 또는 아세톡시메틸이나 카바모일옥시메틸기, 또는 R2가 S 및 N에서 선택된 임의로 치환된 1-4개의 헤테로 원자를 함유하는 5-6개의 고리를 가진 헤테로사이클을 나타내는 경우의 -CH2-S-R2기, 혹은 -CH2-R2기 또는나기를 나타내며, R3는 수소 또는 1-5개의 탄소원자를 가진 알킬, 에스테르, 유기산, 또는 아미드기를 나타낸다. M은 수소원자, 알카리나, 알카리토금속, 또는 에스테르를 나타내며 COOM기는 CO2를 나타내기도 하며, Z이나를 나타내는 경우 COOM은 COO-를 나타내며, X는 할로겐원자이고, n은 0내지 2의 정수이다.z is hydrogen or a halogen atom or an alkyl, cycloalkyl, alkoxy or alkylthio group having up to 5 carbon atoms, or an acetoxymethyl or carbamoyloxymethyl group, or R 2 optionally substituted 1- —CH 2 —SR 2 groups, or —CH 2 —R 2 groups when representing a heterocycle having 5-6 rings containing 4 hetero atoms, or I R 3 represents hydrogen or an alkyl, ester, organic acid, or amide group having 1-5 carbon atoms. M represents a hydrogen atom, an alkali, an alkaline earth metal, or an ester and the COOM group also represents CO 2 , where Z is I If it represents a COOM is COO - represents the, X is a halogen atom, n is an integer from 0 to 2. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019860005314A 1986-07-01 1986-07-01 Method for preparing cephalosporin derivative KR880001673A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1019860005314A KR880001673A (en) 1986-07-01 1986-07-01 Method for preparing cephalosporin derivative
JP62155236A JPS6322585A (en) 1986-07-01 1987-06-22 Production of 6-trifuluoromethyl-1h-benzotriazole-1-yl- diphnylphosphate and cephalosporine derivative
DE19873721305 DE3721305A1 (en) 1986-07-01 1987-06-27 6-TRIFLUORMETHYL-1H-BENZOTRIAZOL-1-YL-DIPHENYLPHOSPHATE AND ITS USE FOR PRODUCING CEPHALOSPORINE DERIVATIVES
IT8721133A IT1206796B (en) 1986-07-01 1987-06-30 6-TRIFLUOROMETIL-1H-BENZOTRIAZOL-1ILE-DIPHENYLPHOSPHATE AND ITS USE FOR THE PREPARATION OF CEPHALOSCPORIN DERIVATIVES.
GB08715337A GB2193213A (en) 1986-07-01 1987-06-30 6-trifluoromethyl-1H-benzotriazol-1-yl diphenylphosphate and its use in preparing cephalosporin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019860005314A KR880001673A (en) 1986-07-01 1986-07-01 Method for preparing cephalosporin derivative

Publications (1)

Publication Number Publication Date
KR880001673A true KR880001673A (en) 1988-04-26

Family

ID=19250872

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860005314A KR880001673A (en) 1986-07-01 1986-07-01 Method for preparing cephalosporin derivative

Country Status (5)

Country Link
JP (1) JPS6322585A (en)
KR (1) KR880001673A (en)
DE (1) DE3721305A1 (en)
GB (1) GB2193213A (en)
IT (1) IT1206796B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR890100706A (en) * 1989-10-31 1992-03-20 Han Mi Pharma Ind Co Ltd Method of preparation of cepheme derivatives
TW369530B (en) * 1993-06-10 1999-09-11 Lucky Ltd Process for preparing cephalosporin compounds from reactive organic acid derivatives
KR100197788B1 (en) * 1995-06-30 1999-06-15 김충환 Processes for manufacturing cephem derivatives
CN1898254A (en) 2003-10-30 2007-01-17 马萨诸塞州立大学 New coupling agents for peptide synthesis

Also Published As

Publication number Publication date
DE3721305A1 (en) 1988-01-14
GB8715337D0 (en) 1987-08-05
JPS6322585A (en) 1988-01-30
GB2193213A (en) 1988-02-03
IT1206796B (en) 1989-05-03
IT8721133A0 (en) 1987-06-30

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E902 Notification of reason for refusal
E601 Decision to refuse application